ChemicalBook > CAS DataBase List > Ro 5-3335
Ro 5-3335
- Product Name
- Ro 5-3335
- CAS No.
- 30195-30-3
- Chemical Name
- Ro 5-3335
- Synonyms
- Ro 5-3335;NSC-66020;Ro5-3335 ，E1245;CBFβ-Runx1 inhibitor II;7-Chloro-5-(1H-pyrrol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one;7-Chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one;7-Chloro-2-oxo-5-(1H-pyrrol-2-yl)-2,3-dihydro-1H-1,4-benzodiazepine;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-;Ro5-3335,Ro53335,CBFβ,inhibit,binding,Ro-5-3335,core,RUNX1,RUNX1-CBFB,factor,CBF,interaction,leukemia,Inhibitor,Ro5 3335
- CBNumber
- CB31365501
- Molecular Formula
- C13H10ClN3O
- Formula Weight
- 259.69
- MOL File
- 30195-30-3.mol
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Ro 5-3335 Property
- Melting point:
- 256 °C(dec.)
- solubility
- Soluble to 100 mM in DMSO
- form
- powder to crystal
- color
- White to Light red to Green
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Safety
- WGK Germany
- WGK 3
- HS Code
- 2933.99.8290
- Storage Class
- 11 - Combustible Solids
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- R0223
- Product name
- Ro 5-3335
- Packaging
- 10MG
- Price
- $167
- Updated
- 2025/07/31
TCI Chemical
- Product number
- R0223
- Product name
- Ro 5-3335
- Packaging
- 50MG
- Price
- $586
- Updated
- 2025/07/31
Tocris
- Product number
- 4694
- Product name
- Ro 5-3335
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $238
- Updated
- 2021/12/16
TRC
- Product number
- R700978
- Product name
- Ro 5-3335
- Packaging
- 10mg
- Price
- $215
- Updated
- 2021/12/16
Usbiological
- Product number
- 256486
- Product name
- Ro 5-3335
- Packaging
- 10mg
- Price
- $495
- Updated
- 2021/12/16
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Ro 5-3335 Chemical Properties,Usage,Production
Uses
Ro 5-3335 is a benzodiazepine is a core binding factor (CBF) leukemia inhibitor.
Definition
ChEBI: A 1,4-benzodiazepinone that is nordazepam in which the phenyl substituent has been replaced by a 1H-pyrrol-2-yl group. It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivati n.
in vivo
Ro5-3335 is identified as an inhibitor of RUNX1–CBFβ function in zebrafish models[1].
Ro5-3335 rescues preleukemic phenotype in a RUNX1-ETO transgenic zebrafish[1].
Ro5-3335 (300 mg/kg/d; p.o; for 30 days) reduces leukemia burden in a mouse CBFB-MYH11 leukemia model[1].
| Animal Model: | C57BL/6 mice (leukemic model)[1] |
| Dosage: | 300 mg/kg |
| Administration: | Oral administration; daily; for 30 days |
| Result: | Reduced the number of c-kit+ cells in the transplanted mice and leukemic cell infiltration in the livers, bone marrow and spleen. |
storage
Store at +4°C
Ro 5-3335 Preparation Products And Raw materials
Raw materials
Preparation Products
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Ro 5-3335 Suppliers
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