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ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT

Product Name
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
CAS No.
71997-40-5
Chemical Name
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
Synonyms
oATP;Oxidized ATP (oATP);Oxidized ATP trisodium salt;adenosine 5'-triphosphate-2',3'-dialdehyde;ADENOSINE 5'-TRIPHOSPHATE PERIODATE OXIDIZED;Adenosine 5′-triphosphate, periodate oxidized;Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem;ADENOSINE 5-TRIPHOSPHATE, PERIODATEOXIDI ZED SODIUM;ADENOSINE 5'-TRIPHOSPHATE-2', 3'-DIALDEHYDE SODIUM SALT;Adenosine 5`-triphosphate sodiuM salt periodate oxidized
CBNumber
CB3141054
Molecular Formula
C10H13N5NaO13P3
Formula Weight
527.15
MOL File
71997-40-5.mol
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ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Property

storage temp. 
-20°C
form 
White powder
color 
White to off-white
biological source
bacterial (corynebacterium sp)
Water Solubility 
water: 50mg/mL
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A6779
Product name
Adenosine 5′-triphosphate, periodate oxidized sodium salt
Purity
≥97%
Packaging
25mg
Price
$255
Updated
2025/07/31
Sigma-Aldrich
Product number
A6779
Product name
Adenosine 5′-triphosphate, periodate oxidized sodium salt
Purity
≥97%
Packaging
100mg
Price
$800
Updated
2025/07/31
Sigma-Aldrich
Product number
5.05758
Product name
Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem
Packaging
25mg
Price
$259
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
NUC0003769
Product name
ADENOSINE-5'-TRIPHOSPHATE PERIODATE OXIDIZED SODIUM SALT
Purity
95.00%
Packaging
0.5G
Price
$1478.4
Updated
2021/12/16
AHH
Product number
MT-46686
Product name
Adenosine 5′-triphosphate, periodate oxidized sodium salt
Purity
95%
Packaging
0.25g
Price
$380
Updated
2021/12/16
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ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Chemical Properties,Usage,Production

Uses

Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:

  • as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
  • as a nonspecific agonist to assess the activity of P2×7-R by the mobilization of Ca2+
  • to evaluate the physiological significance of elevated intracellular ATP levels
  • increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells

General Description

A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.

Biochem/physiol Actions

Reversible: no

in vivo

Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice[2].

Animal Model:Induced mouse experimental autoimmune uveitis (EAU)[2]
Dosage:300 μg/mouse
Administration:i.p.
Result:Showed almost undetected EAU, as shown by fundoscopic and pathologic examination.
Decreased serum IL-17 level.
Mitigated the autoreactive T cell response.

IC 50

NLRP3 inflammasome; P2X7 Receptor

ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Suppliers

China 12 Switzerland 1 United Kingdom 2 United States 5 Global 20
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Santa Cruz Biotechnology Inc
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TargetMol Chemicals Inc.
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71997-40-5, ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALTRelated Search:

DL-GLYCERALDEHYDE 3-PHOSPHATE ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT ADENOSINE, PERIODATE OXIDIZED 2,2'-oxybisacetaldehyde

  • ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
  • ADENOSINE 5'-TRIPHOSPHATE-2', 3'-DIALDEHYDE SODIUM SALT
  • oATP
  • Adenosine 5′-triphosphate, periodate oxidized
  • ADENOSINE 5-TRIPHOSPHATE, PERIODATEOXIDI ZED SODIUM
  • adenosine 5'-triphosphate-2',3'-dialdehyde
  • Adenosine 5`-triphosphate sodiuM salt periodate oxidized
  • Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem
  • Oxidized ATP trisodium salt
  • ADENOSINE 5'-TRIPHOSPHATE PERIODATE OXIDIZED
  • Oxidized ATP (oATP)
  • 71997-40-5
  • C10H14N5O13P3
  • C10H13N5NaO13P3
  • Nucleotides
  • Nucleosides, Nucleotides, Oligonucleotides
  • Biochemicals and Reagents
  • BioChemical