HYOCHOLIC ACID

Product Name: HYOCHOLIC ACID
CAS No.: 547-75-1
Chemical Name: HYOCHOLIC ACID
Synonyms: GAMMA MURICHOLIC;Hyocholic acid (HCA);3a,6a,7a-Trihydroxy-5b-cholanic acid;6B1;3u0003B1;6u0003B1;7u0003B1;HYOCHOLIC ACID;-trihydroxy-5B2;gamma-Muricholate
CBNumber: CB3141135
Molecular Formula: C24H40O5
Formula Weight: 408.57
MOL File: 547-75-1.mol

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HYOCHOLIC ACID Property

Melting point:: 162 °C
Boiling point:: 565.7±40.0 °C(Predicted)
Density: 1.184±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Ethanol (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 4.76±0.10(Predicted)
color: Light Brown to Brown
optical activity: +5.525
InChIKey: DKPMWHFRUGMUKF-KWXDGCAGSA-N
SMILES: O[C@H]1[C@@H]2[C@@H]([C@@]4([C@H]([C@H]1O)C[C@@H](CC4)O)C)CC[C@]3([C@H]2CC[C@@H]3[C@@H](CCC(=O)O)C)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20293
Product name: Hyocholic Acid
Purity: ≥95%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20293
Product name: Hyocholic Acid
Purity: ≥95%
Packaging: 1mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 20293
Product name: Hyocholic Acid
Purity: ≥95%
Packaging: 5mg
Price: $163
Updated: 2024/03/01

Cayman Chemical

Product number: 20293
Product name: Hyocholic Acid
Purity: ≥95%
Packaging: 10mg
Price: $263
Updated: 2024/03/01

TRC

Product number: T795105
Product name: 3α,6α,7α-Trihydroxy-5β-cholanicAcid
Packaging: 25mg
Price: $445
Updated: 2021/12/16

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HYOCHOLIC ACID Chemical Properties,Usage,Production

Uses

3α,6α,7α-Trihydroxy-5β-cholanic Acid is one of the bile acids categorizes under muricholic acid, a group of bile acids found in human urine due to its additional hydroxyl groups. The synthesis of 3α,6α,7α-Trihydroxy-5β-cholanic Acid was shown to be promoted due to overexpression of cholesterol 7α-hydroxylase enzyme.

Definition

ChEBI: A trihydroxy-5beta-cholanic acid in which the three hydroxy substituents are located at the 3alpha-, 6alpha- and 7alpha-positions.

Biological Activity

Hyocholic acid levels are elevated in plasma and urine samples of patients with cholestatic liver disease and in hepatic cirrhosis.

in vivo

Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs^[3].
Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models^[3].

Animal Model:	BA depletion pigs^[3]
Dosage:	20 mg/kg
Administration:	Oral administration (p.o.)
Result:	Attenuated the increased blood glucose levels corresponding with GLP-1 decrease.

Animal Model:	db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model^[3]
Dosage:	100 mg/kg/day
Administration:	Oral administration (p.o.)
Result:	Improved oral glucose tolerances shown by lower glucose levels. Increased circulating active GLP-1 levels and fasting insulin levels.

HYOCHOLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

BILE SALTS Cholic acid

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HYOCHOLIC ACID Suppliers

Canada 1 China 125 Germany 1 India 2 United Kingdom 2 United States 8 Global 139

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ShangHai Biochempartner Co.,Ltd

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View Lastest Price from HYOCHOLIC ACID manufacturers

Handan Tongyi New Material Technology Co., Ltd

Product: HYOCHOLIC ACID 547-75-1
Price: US $1.00/Kg
Min. Order: 1KG
Purity: 99.99%
Supply Ability: 500 Metric Ton/Day
Release date: 2021-03-01

547-75-1, HYOCHOLIC ACIDRelated Search:

Baicalin 12-HYDROXYDODECANOIC ACID CHOLANIC ACID HYOCHOLIC ACID Hyodeoxycholic acid 9,10-DIHYDROXYSTEARIC ACID Ursodeoxycholic acid 16-HYDROXYHEXADECANOIC ACID LITHOCHOLIC ACID 2,7-Decahydronaphthalenediol 12-HYDROXYSTEARIC ACID 5BETA-CHOLANIC ACID 5beta-Cholan-3alpha,7alpha,24-triol CIS,TRANS,TRANS-3,5-DIMETHYLCYCLOHEXANOL ERYTHRO-5,6-DODECANEDIOL HYOCHOLIC ACID METHYL ESTER 5-BETA-CHOLAN-24-OL Hyodeoxycholic acid Impurity 9

LAMBDA-MURICHOLIC ACID

HYOCHOLIC ACID

GAMMA MURICHOLIC

3,6,7-trihydroxy-,(3alpha,5beta,6alpha,7alpha)-cholan-24-oicaci

3-ALPHA,6-ALPHA,7-ALPHA-TRIHYDROXY-5-BETA-CHOLAN-24-OIC ACID

3A,6A-7A-TRIHYDROXY-5B-CHOLAN-24-OIC ACID

5B-CHOLAN-24-OIC ACID-3A,6A,7A-TRIOL

5-BETA-CHOLAN-24-OIC ACID-3-ALPHA,6-ALPHA,7-ALPHA-TRIOL

5-BETA-CHOLANIC ACID-3-ALPHA, 6-ALPHA, 7-ALPHA-TRIOL

4-(3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

3α,6α,7α-Trihydroxy-5β-cholan-24-oic acid

(4R)-4-[(3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid

3α,6α,7α-Trihydroxy-5β-cholanic Acid

3-ALPHA,6-ALPHA,7-ALPHA-

Porcine cholic acid

HYOCHOLIC ACIDHYOCHOLIC ACID

Hyocholic acid (HCA)

Cholan-24-oic acid, 3,6,7-trihydroxy-, (3α,5β,6α,7α)-

(R)-4-((3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

5β-Cholanic acid-3α,6α,7α-triol

3a,6a,7a-Trihydroxy-5b-cholanic acid

3u0003B1

6B1

6u0003B1

7u0003B1

-cholan-24-oic acid

-trihydroxy-5B2

-trihydroxy-5u0003B2

GAMMA-MURICHOLIC ACID

2H5]-γ-Muricholic Acid

Allocholic Acid Impurity 11 (Hyocholic Acid)

alpha-Hyocholic acid

gamma-Muricholate

γ-Muricholic Acid/Hyocholic Acid

5β-Cholan-24-Oic Acid-3α,6α,7α-Triol

Hyocholic acid, 10 mM in DMSO

Cholan-24-oic acid, 3,6,7-trihydroxy-, (3α,5β,6α,7α)-

D5-γ-Muricholic Acid

Hyocholic acid Impurity 1

3,6,7-trihydroxy-5-cholan-24-oic acid

547-75-1