ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Uses

Product Name: ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
CAS No.: 110543-98-1
Chemical Name: ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.
Synonyms: Arbidol Impurity 62;Arbidol Impurity 40;Abidore Impurity 31;Abbidore intermediate 4;5-Acetoxy-6-bromo-2-(bromomethyL;Ethyl 5-acetoxy-6-broMo-2-broMoMethyl-1-Methylindo;ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.;ETHYL 5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METH 110543-98-1;Ethyl 5-Acetoxy-6-Bromo-2-(Bromomethyl)-1-Methylindole-3-Car...;Ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-metyl-indol-3carboxylate
CBNumber: CB31430768
Molecular Formula: C15H15Br2NO4
Formula Weight: 433.09
MOL File: 110543-98-1.mol

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ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Property

Melting point:: 168-171 °C(Solv: carbon tetrachloride (56-23-5))
Boiling point:: 529.8±50.0 °C(Predicted)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Brown to gray Solid
InChI: InChI=1S/C15H15Br2NO4/c1-4-21-15(20)14-9-5-13(22-8(2)19)10(17)6-11(9)18(3)12(14)7-16/h5-6H,4,7H2,1-3H3
InChIKey: MESMQGKAVXOGHJ-UHFFFAOYSA-N
SMILES: N1(C)C2=C(C=C(OC(C)=O)C(Br)=C2)C(C(OCC)=O)=C1CBr
CAS DataBase Reference: 110543-98-1(CAS DataBase Reference)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E898813
Product name: Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1h-indole-3-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E898813
Product name: Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1h-indole-3-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: X8949
Product name: Ethyl5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate
Packaging: 25g
Price: $137
Updated: 2021/12/16

Apolloscientific

Product number: OR350162
Product name: Ethyl 5-Acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-carboxylate
Packaging: 5g
Price: $176
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-9-1E
Product name: Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methylindole-3-carboxylate
Packaging: 5G
Price: $208
Updated: 2021/12/16

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ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Chemical Properties,Usage,Production

Uses

Ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate can be used as an intermediate for Arbidol.

Synthesis

40945-79-7

110543-98-1

General procedure for the synthesis of ethyl 1-methyl-2-(bromomethyl)-5-acetoxy-6-bromoindole-3-carboxylate from ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate: 137.6 g (0.45 mol) of ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate was dissolved in 1000 mL of chloroform with stirring until completely dissolved. A catalytic amount of benzoyl peroxide was added and heated to reflux. 64.0 mL (200 g, 1.25 mol) of liquid bromine was added slowly dropwise and the reaction was continued at reflux for 3 hours after completion of the dropwise addition. Upon completion of the reaction, the reaction mixture was cooled to room temperature and a solid was precipitated. The solid was washed with a small amount of methanol and dried to give 184.0 g of ethyl 1-methyl-2-(bromomethyl)-5-acetoxy-6-bromoindole-3-carboxylate in 85.0% yield.

References

[1] Pharmaceutical Chemistry Journal, 1993, vol. 27, # 1, p. 75 - 76
[2] Khimiko-Farmatsevticheskii Zhurnal, 1993, vol. 27, # 1, p. 70 - 71
[3] Patent: CN106083691, 2016, A. Location in patent: Paragraph 0025; 0055; 0056
[4] Patent: US5198552, 1993, A
[5] Patent: EP1731506, 2006, A1. Location in patent: Page/Page column 12; 16

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Suppliers

China 115 India 3 United Kingdom 1 United States 10 USA 1 Global 130

Shandong Jiecheng Pharmaceutical Co., Ltd

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View Lastest Price from ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. manufacturers

Nanjing Fred Technology Co., Ltd

Product: Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate 110543-98-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%HPLC
Supply Ability: 20 tons
Release date: 2023-12-04

Career Henan Chemical Co

Product: ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. 110543-98-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 477
Release date: 2019-09-01

Career Henan Chemical Co

Product: ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. 110543-98-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 478
Release date: 2019-09-01

110543-98-1, ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.Related Search:

1-Methylindole 1-Methyl-1H-indole-3-carboxylic acid

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Ethyl5-acetyloxy-6-bromo-2-bromomethyl-1-methylindole-3- Carboxylate

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-metyl-indol-3carboxylate

Ethyl 5-Acetoxy-6-broMo-2-(broMoMethyl)-1-Methylindole-3-carboxylate

Ethyl 5-acetoxy-6-broMo-2-broMoMethyl-1-Methylindo

5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

5-Acetoxy-6-bromo-2-(bromomethyL

1H-Indole-3-carboxylic acid, 5-(acetyloxy)-6-bromo-2-(bromomethyl)-1-methyl-, ethyl ester

Arbidol Impurity 62

ETHYL 5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METH 110543-98-1

Arbidol Impurity 40

Ethyl 5-Acetoxy-6-Bromo-2-(Bromomethyl)-1-Methylindole-3-Car...

TIANFU CHEM ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

5-Acetoxy-6-bromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylicacid

Abbidore intermediate 4

Ethyl5-Acetoxy-6-Bromo-2-(Bromomethyl)-1-Methylind ole-3-Carboxylat

Abidore Impurity 31

110543-98-1

C15H15Br2NO4

arbidol