Description History Physical properties Safety description chemical properties ε-Polylysine
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Epsilon-polylysine

Description History Physical properties Safety description chemical properties ε-Polylysine
Product Name
Epsilon-polylysine
CAS No.
28211-04-3
Chemical Name
Epsilon-polylysine
Synonyms
ε-Polylysine;ε-Poly-L-lysine;epsilon-Polylysin;E-Polylysine;ε-PL;ε-Polylysine,ε-PL;Poly epsilon L-lysine;Poly[imino[(2S)-2-amino-1-oxo-1,6-hexanediyl]];ε-poly-L-lysin;ε-poly-L-lysineHC
CBNumber
CB31447735
Molecular Formula
C8H18N2O
Formula Weight
158.24132
MOL File
28211-04-3.mol
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Epsilon-polylysine Property

Melting point:
172 °C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Pale Yellow
InChI
InChI=1/C8H18N2O/c1-3-4-5-6-7(9)8(11)10-2/h7H,3-6,9H2,1-2H3,(H,10,11)/t7-/s3
InChIKey
YLBHPLDJISPYOJ-KPOCXSGKNA-N
SMILES
C(NC)(=O)[C@@H](N)CCCCC |&1:4,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot
Product number
CD00005018
Product name
E-Polylysine
Purity
97%
Packaging
100g
Price
$150
Updated
2021/12/16
Crysdot
Product number
CD00005018
Product name
E-Polylysine
Purity
97%
Packaging
500g
Price
$450
Updated
2021/12/16
Labseeker
Product number
SC-97612
Product name
E-polylysine
Purity
99
Packaging
1kg
Price
$700
Updated
2021/12/16
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Epsilon-polylysine Chemical Properties,Usage,Production

Description

ε-Polylysine is a light yellow powder with strong hygroscopicity and slightly bitter taste. It is a linear polymer of lysine. It is produced by streptomyces fermentation and has a broad-spectrum antibacterial effect. ε-polylysine is polymerized by 25-30 lysine groups, which is relatively stable to pH and heat. Its antibacterial effect is related to the degree of polymerization and the environment. The molecular weight of polylysine is between 3600-4300 which has the best antibacterial activity.

History

In 1977, Japanese scholars S. Shima and H. Sakai, in the process of screening Dragendo~Positive (DP) substances from microorganisms, discovered that a strain of actinomycete No.346 can produce a large amount of stable DP substances. The analysis and structural analysis of the hydrolysate confirmed that the DP substance is a homopolymer of 25-30 lysine residues. A homologous amino acid polymer formed by NH2 condensation, so it is called ε-Poly-L-lysine (ε-Poly-L-lysine for short ε-PL).

Physical properties

ε-PL pure product is light yellow powder, slightly bitter, strong hygroscopicity, and slightly bitter. It is easily soluble in water, slightly soluble in ethanol, but insoluble in organic solvents such as ethyl acetate and ether. It has high stability and antibacterial effect.

Safety

ε-PL enters the human body and is converted into lysine through digestion and decomposition. Lysine is one of the eight essential amino acids for the human body. It is an amino acid allowed to be added to food and is non-toxic and harmless to the human body. Therefore, ε -PL as a nutritional bacteriostatic agent, its safety is much higher than other chemical preservatives.

description

Epsilon-polylysine (ε-PL) is an antimicrobial commercially produced by Streptomyces fermentation and widely used in Asian countries for food preservation. epsilon-polylysine is approved for food use in Japan as an antimicrobial preservative.
Epsilon-polylysine (ε-PL) is a small cationic isopeptide made from the essential amino acid L-lysine. It exhibits antimicrobial activity against a wide spectrum of bacteria, yeast, and fungi and is heat stable and active in different food matrices. ε-PL has been a popular food preservative in Japan since the late 1980s, followed by Korea and China, and has been given Generally Regarded As Safe (GRAS) status in the USA. As a secondary metabolite, ε-PL was first discovered from the soil bacterium Streptomyces albulus, which is still used in its commercial production. Later, more producers of ε-PL were identified from the family of Streptomycetaceae, including the genera Streptomyces and Kitasatospora, and ergot fungi. ε-PL is synthesized by a cell-membrane-bound nonribosomal peptide synthetase (NRPS)-like enzyme named ε-PL synthetase (Pls).
Distribution of Epsilon-Polylysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin

chemical properties

Epsilon-polylysine is produced in Japan, and levels as low as 5 ppm have been found to be inhibitory, especially of some Gram-positive bacteria. It is water soluble, effective over a wide pH range, and is degraded to lysine by proteases.

ε-Polylysine

ε-Polylysine (ε-poly-L-lysine, EPL) is typically produced as a homopolypeptide of approximately 25–30 L-lysine residues.
Epsiliseen®- H is a natural antimicrobial agent with ultra-high concentration of E-Polylysine, used in food, cosmeceutical and pharmaceutical applications.
ε-Polylysine (ε-poly-L-lysine), the main active ingredient in Epsiliseen®, is a small polypeptide of the essential amino acid L-lysinethat is produced by bacterial fermentation; the natural fermentation is only observed in strains of bacteria in the genus Streptomyces.
ε-Polylysine is commercially used as a food preservative in Japan, the republic of Korea and in the USA. Food products containing polylysine are mainly found in Japan. The use of polylysine is common in food applications like: boiled rice, cooked vegetables, soups, noodles and sliced fish (sushi).

Chemical Properties

from Streptomyces albulus.

Uses

ε-Poly-L-lysine posess antimicrobial action stronger than alpha-Poly-L-lysine. Studies on the mode of action of ε-?PL suggest that adsorption of ε-?PL to the bacterial cell surface plays an important role in its antibacterial activity.

Definition

ChEBI: A macromolecule composed of repeating L-lysyl units joined via 1,6-amide linkages.

Epsilon-polylysine Preparation Products And Raw materials

Raw materials

Preparation Products

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Epsilon-polylysine Suppliers

BeiJing TOP Science Bio-Technology Co., Ltd.
Tel
+86-13439059536 +86-15201677815
Country
China
ProdList
291
Advantage
58
Lingyuan Bebiansen Biological Technology Co., Ltd
Tel
18642120371
Email
2837458851@qq.com
Country
China
ProdList
7995
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ:2779667926
Email
buy@fortunachem.com
Country
China
ProdList
2792
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
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View Lastest Price from Epsilon-polylysine manufacturers

airuikechemical co., ltd.
Product
ε-Polylysine 28211-04-3
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-07-12
WUHAN FORTUNA CHEMICAL CO., LTD
Product
EPSILON-POLYLYSINE 28211-04-3
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500KG
Release date
2021-06-01
WUHAN FORTUNA CHEMICAL CO., LTD
Product
epsilon-Polylysin 28211-04-3
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98.00%
Supply Ability
500kg/month
Release date
2021-06-08

28211-04-3, Epsilon-polylysineRelated Search:


  • epsilon-Polylysin
  • ε-Polylysine,ε-PL
  • Poly epsilon L-lysine
  • Poly[imino[(2S)-2-amino-1-oxo-1,6-hexanediyl]]
  • EPSILON-polylysine,e-Polylysine
  • poly(L-lysine) macromolecule
  • ε-poly-L-lysin
  • ε-Poly-L-lysine
  • ε-Polylysine
  • ε-PL
  • ε-poly-L-lysineHC
  • E-Polylysine
  • EPSILON-POLYLYSINE USP/EP/BP
  • EPSILON-POLYLYSINE
  • E-polylyhelic acid
  • FEMA 2763 124-25-4
  • ε-Poly-L-lysine (MW 3800-4200)
  • ε-Poly-L-lysine hydrochloride,from Streptomyces albulus,Mw ~4000
  • ε-poly-L-lysine?HCl, ε-PL?HCl
  • Carbidopa Impurity 22
  • 28211-04-3
  • C6H12N2On
  • C8H18N2On
  • Other APIs