(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Uses

Product Name: (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
CAS No.: 443776-76-9
Chemical Name: (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Synonyms: 3-Hydroxymethylphenylboronic acid, pinacol ester;3-(Hydroxymethyl)benzeneboronicacid,pinacolester96%;3-(Hydroxymethyl)phenylboronic acid pinacol ester - [H3213];3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol;3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol;Benzenemethanol, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-(3-Hydroxymethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CBNumber: CB31457389
Molecular Formula: C13H19BO3
Formula Weight: 234.1
MOL File: 443776-76-9.mol

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(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Property

Melting point:: 42-46 °C
Boiling point:: 363.7±25.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
Flash point:: 110 °C
storage temp.: Inert atmosphere,2-8°C
pka: 14.34±0.10(Predicted)
form: powder to lump
color: White to Almost white
InChI: InChI=1S/C13H19BO3/c1-12(2)13(3,4)17-14(16-12)11-7-5-6-10(8-11)9-15/h5-8,15H,9H2,1-4H3
InChIKey: ZEWWJJQAFTXUIS-UHFFFAOYSA-N
SMILES: C1(CO)=CC=CC(B2OC(C)(C)C(C)(C)O2)=C1

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Safety

WGK Germany: 3
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3830
Product name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
Packaging: 1G
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: T3830
Product name: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
Packaging: 5G
Price: $91
Updated: 2025/07/31

TRC

Product number: H972565
Product name: 3-(Hydroxymethyl)phenylboronic acid pinacol ester
Packaging: 5g
Price: $165
Updated: 2021/12/16

TRC

Product number: H972565
Product name: 3-(Hydroxymethyl)phenylboronic acid pinacol ester
Packaging: 1g
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR11503
Product name: 3-(Hydroxymethyl)benzeneboronic acid pinacol ester
Purity: 96%
Packaging: 1g
Price: $58
Updated: 2021/12/16

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(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Chemical Properties,Usage,Production

Uses

Pinaryl 3-hydroxymethylphenylboronic acid can be used as a pharmaceutical synthesis intermediate.

Synthesis

380151-86-0

443776-76-9

GENERAL METHOD: Methanol (12.50 mL) was added to a mixture of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (1a, 375 mg, 2.50 mmol), pinacol (355 mg, 3.00 mmol) and anhydrous magnesium sulfate (625 mg, 5.00 mmol). The mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the crude reaction mixture was filtered and then sodium borohydride (47 mg, 1.25 mmol) was added to the filtrate. Subsequently, the reaction mixture was stirred for another 5 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated in vacuum to afford the target product 3-hydroxymethylphenylboronic acid pinacol ester (2a) as a white solid (melting point 75-77 °C) in 88% yield (513 mg).1H-NMR (CD3OD-d4) δ ppm: 7.71 (d, J=8.0 Hz, 2H), 7.35 (d, J=7.8 Hz. 2H), 4.62 (s, 2H), 1.34 (s, 12H); 13C-NMR (CD3OD-d4) δppm: 146.23, 135.93, 127.26, 85.19, 65.24, 25.34; 11B-NMR (CDCl3) δppm: 34.82.

References

[1] Molecules, 2013, vol. 18, # 10, p. 12346 - 12367

(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Preparation Products And Raw materials

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Preparation Products

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(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Suppliers

China 85 India 4 Japan 1 Switzerland 1 United Kingdom 1 United States 7 Global 99

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View Lastest Price from (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 443776-76-9
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(HydroxyMethyl)benzeneboronic acid pinacol ester 443776-76-9
Price: US $1.00-1.00/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-26

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(HydroxyMethyl)benzeneboronic acid pinacol ester 443776-76-9
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-15

443776-76-9, (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanolRelated Search:

(3-CARBOXY-5-NITROPHENYL)BORONIC ACID, PINACOL ESTER 3-Carboxyphenylboronic acid pinacol ester 3-Methoxycarbonylphenylboronic acid pinacol ester (3-AMINO-5-METHOXYCARBONYL)BENZENEBORONIC ACID PINACOL ESTER HYDROCHLORIDE (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Methyl 3-Amino-5-boronobenzoate, pinacol ester ETHYL 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 3-(METHOXYMETHYL)PHENYLBORONIC ACID, PINACOL ESTER 2-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID 2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER (3-ACETOXYMETHYLPHENYL)BORONIC ACID PINACOL ESTER 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID 3-TERT-BUTOXYCARBONYLPHENYLBORONIC ACID PINACOL ESTER 3-(Phenoxymethyl)benzeneboronic acid, pinacol ester 2-(5-[1,3]DIOXOLAN-2-YL-2,4-DIMETHOXY-PHENYL)-BORONIC ACID PINACOL ESTER Methyl 3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 2-HYDROXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER

3-Hydroxymethylphenylboronic acid, pinacol ester

3-(Hydroxymethyl)benzeneboronicacid,pinacolester96%

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol

2-(3-Hydroxymethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Benzenemethanol, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

3-(Hydroxymethyl)phenylboronic acid pinacol ester - [H3213]

443776-76-9

Aryl

Boronate Esters

Boronic Acids and Derivatives

blocks

BoronicAcids

Aryl Boronate Esters

Boronate Esters

Boronic Acids and Derivatives

Chemical Synthesis

Organometallic Reagents