Uses
ChemicalBook > CAS DataBase List > (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Uses
Product Name
(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
CAS No.
443776-76-9
Chemical Name
(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Synonyms
3-Hydroxymethylphenylboronic acid, pinacol ester;3-(Hydroxymethyl)benzeneboronicacid,pinacolester96%;3-(Hydroxymethyl)phenylboronic acid pinacol ester - [H3213];3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol;3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol;Benzenemethanol, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-(3-Hydroxymethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CBNumber
CB31457389
Molecular Formula
C13H19BO3
Formula Weight
234.1
MOL File
443776-76-9.mol
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(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Property

Melting point:
42-46 °C
Boiling point:
363.7±25.0 °C(Predicted)
Density 
1.07±0.1 g/cm3(Predicted)
Flash point:
110 °C
storage temp. 
Inert atmosphere,2-8°C
pka
14.34±0.10(Predicted)
form 
powder to lump
color 
White to Almost white
InChI
InChI=1S/C13H19BO3/c1-12(2)13(3,4)17-14(16-12)11-7-5-6-10(8-11)9-15/h5-8,15H,9H2,1-4H3
InChIKey
ZEWWJJQAFTXUIS-UHFFFAOYSA-N
SMILES
C1(CO)=CC=CC(B2OC(C)(C)C(C)(C)O2)=C1
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Safety

WGK Germany 
3
HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3830
Product name
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
Packaging
1G
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
T3830
Product name
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
Packaging
5G
Price
$91
Updated
2025/07/31
TRC
Product number
H972565
Product name
3-(Hydroxymethyl)phenylboronic acid pinacol ester
Packaging
5g
Price
$165
Updated
2021/12/16
TRC
Product number
H972565
Product name
3-(Hydroxymethyl)phenylboronic acid pinacol ester
Packaging
1g
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR11503
Product name
3-(Hydroxymethyl)benzeneboronic acid pinacol ester
Purity
96%
Packaging
1g
Price
$58
Updated
2021/12/16
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(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Chemical Properties,Usage,Production

Uses

Pinaryl 3-hydroxymethylphenylboronic acid can be used as a pharmaceutical synthesis intermediate.

Synthesis

380151-86-0

443776-76-9

GENERAL METHOD: Methanol (12.50 mL) was added to a mixture of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (1a, 375 mg, 2.50 mmol), pinacol (355 mg, 3.00 mmol) and anhydrous magnesium sulfate (625 mg, 5.00 mmol). The mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the crude reaction mixture was filtered and then sodium borohydride (47 mg, 1.25 mmol) was added to the filtrate. Subsequently, the reaction mixture was stirred for another 5 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated in vacuum to afford the target product 3-hydroxymethylphenylboronic acid pinacol ester (2a) as a white solid (melting point 75-77 °C) in 88% yield (513 mg).1H-NMR (CD3OD-d4) δ ppm: 7.71 (d, J=8.0 Hz, 2H), 7.35 (d, J=7.8 Hz. 2H), 4.62 (s, 2H), 1.34 (s, 12H); 13C-NMR (CD3OD-d4) δppm: 146.23, 135.93, 127.26, 85.19, 65.24, 25.34; 11B-NMR (CDCl3) δppm: 34.82.

References

[1] Molecules, 2013, vol. 18, # 10, p. 12346 - 12367

(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Suppliers

China 85 India 4 Japan 1 Switzerland 1 United Kingdom 1 United States 7 Global 99
SIGMA-RBI
Tel
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Switzerland
ProdList
6896
Advantage
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View Lastest Price from (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 443776-76-9
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Shaanxi Dideu Medichem Co. Ltd
Product
3-(HydroxyMethyl)benzeneboronic acid pinacol ester 443776-76-9
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
100 tons
Release date
2019-12-26
Shaanxi Dideu Medichem Co. Ltd
Product
3-(HydroxyMethyl)benzeneboronic acid pinacol ester 443776-76-9
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-15

443776-76-9, (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanolRelated Search:

(3-CARBOXY-5-NITROPHENYL)BORONIC ACID, PINACOL ESTER 3-Carboxyphenylboronic acid pinacol ester 3-Methoxycarbonylphenylboronic acid pinacol ester (3-AMINO-5-METHOXYCARBONYL)BENZENEBORONIC ACID PINACOL ESTER HYDROCHLORIDE (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Methyl 3-Amino-5-boronobenzoate, pinacol ester ETHYL 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 3-(METHOXYMETHYL)PHENYLBORONIC ACID, PINACOL ESTER 2-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID 2-METHOXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER (3-ACETOXYMETHYLPHENYL)BORONIC ACID PINACOL ESTER 3-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID 3-TERT-BUTOXYCARBONYLPHENYLBORONIC ACID PINACOL ESTER 3-(Phenoxymethyl)benzeneboronic acid, pinacol ester 2-(5-[1,3]DIOXOLAN-2-YL-2,4-DIMETHOXY-PHENYL)-BORONIC ACID PINACOL ESTER Methyl 3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 2-HYDROXY-5-METHOXYCARBONYLPHENYLBORONIC ACID, PINACOL ESTER

  • 3-Hydroxymethylphenylboronic acid, pinacol ester
  • 3-(Hydroxymethyl)benzeneboronicacid,pinacolester96%
  • 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Alcohol
  • 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol
  • 2-(3-Hydroxymethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • Benzenemethanol, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 3-(Hydroxymethyl)phenylboronic acid pinacol ester - [H3213]
  • 443776-76-9
  • Aryl
  • Boronate Esters
  • Boronic Acids and Derivatives
  • blocks
  • BoronicAcids
  • Aryl Boronate Esters
  • Boronate Esters
  • Boronic Acids and Derivatives
  • Chemical Synthesis
  • Organometallic Reagents