ChemicalBook > CAS DataBase List > [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

Product Name
[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
CAS No.
85081-18-1
Chemical Name
[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
Synonyms
(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol;(+)-DTBZ;NBI-98782;(+)-α-DHTBZ;(+)-α-DHTBZ;(+)-Dihydrotetrabenazine;Tetrabenazine metabolite B;Tetrabenazine metabolite A;(+)-α-Dihydrotetrabenazine;Tetrabenazine Related Impurity 27
CBNumber
CB31465696
Molecular Formula
C19H29NO3
Formula Weight
319.44
MOL File
85081-18-1.mol
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[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Property

Melting point:
106-108 °C(Solv: hexane (110-54-3))
Boiling point:
457.8±45.0 °C(Predicted)
Density 
1.13
storage temp. 
Store at -20°C
solubility 
DMSO : 33.33 mg/mL (104.34 mM; Need ultrasonic)
form 
Powder
pka
14.75±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H336May cause drowsiness or dizziness

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D453615
Product name
(+)-α-Dihydrotetrabenazine
Packaging
100mg
Price
$1470
Updated
2021/12/16
ChemScene
Product number
CS-1899
Product name
NBI-98782
Purity
99.80%
Packaging
5mg
Price
$420
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0001215
Product name
2H-BENZO[A]QUINOLIZIN-2-OL, 1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-, (2R,3R,11BR)-
Purity
95.00%
Packaging
5MG
Price
$500.12
Updated
2021/12/16
ChemScene
Product number
CS-1899
Product name
NBI-98782
Purity
99.80%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-1899
Product name
NBI-98782
Purity
99.80%
Packaging
50mg
Price
$1800
Updated
2021/12/16
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[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Chemical Properties,Usage,Production

Uses

(+)-α-Dihydrotetrabenazine is a potent inhibitor of vascular monoamine transporter 2 (VMAT2) and an agent of significant interest for therapeutic and molecular imaging applications.

Definition

ChEBI: (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol is a member of isoquinolines.

[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Suppliers

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85081-18-1, [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-olRelated Search:

Dimethyldimethoxysilane 2,6-Dimethoxybenzaldehyde 1,1-Dimethoxyethane Diphenyldimethoxysilane Dimethoxymethane 4-Aminobutyric acid N,N-DIETHYLBENZAMIDE Tetrabenazine [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

  • Tetrabenazine metabolite A
  • Tetrabenazine metabolite B
  • 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-
  • [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
  • NBI-98782
  • (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol
  • Tetrabenazine Related Impurity 27 (2R, 3R, 11bR)
  • Tetrabenazine Related Impurity 27
  • (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol
  • (+)-α-DHTBZ
  • (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
  • (+)-α-Dihydrotetrabenazine
  • (+)-DTBZ
  • (+)-α-DHTBZ
  • NBI 98782,NBI-98782,NBI98782,Monoamine Transporter,Inhibitor,inhibit
  • (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol
  • (+)-Dihydrotetrabenazine
  • (2R,3R,11bR)-9,10-dimethoxy-3-(propan-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
  • 85081-18-1
  • Impurities & Metabolites
  • Tetrabenazine