3-Bromofuran-2-carboxylic acid

Product Name: 3-Bromofuran-2-carboxylic acid
CAS No.: 14903-90-3
Chemical Name: 3-Bromofuran-2-carboxylic acid
Synonyms: 3-bromo-2-furanoic acid;3-Bromofuran-2-carboxylic acid;3-bromo-2-furancarboxylic acid;2-Furancarboxylic acid,3-broMo-
CBNumber: CB31466466
Molecular Formula: C5H3BrO3
Formula Weight: 190.98
MOL File: 14903-90-3.mol

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3-Bromofuran-2-carboxylic acid Property

Melting point:: 127-129 °C
Boiling point:: 278.0±25.0 °C(Predicted)
Density: 1.891±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Chloroform, DCM, Ethyl Acetate
form: Solid
pka: 2.77±0.20(Predicted)
color: Light Brown
InChI: InChI=1S/C5H3BrO3/c6-3-1-2-9-4(3)5(7)8/h1-2H,(H,7,8)
InChIKey: UZBGSJZFBUOJNE-UHFFFAOYSA-N
SMILES: O1C=CC(Br)=C1C(O)=O

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-26-36/37/39
HS Code: 2932190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B682665
Product name: 3-Bromo-2-furoicAcid
Packaging: 5g
Price: $970
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0036573
Product name: 3-BROMO-2-FUROIC ACID
Purity: 95.00%
Packaging: 2.5G
Price: $1201.49
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0036573
Product name: 3-BROMO-2-FUROIC ACID
Purity: 95.00%
Packaging: 5G
Price: $1506.05
Updated: 2021/12/16

AK Scientific

Product number: Z5464
Product name: 3-Bromofuran-2-carboxylicacid
Packaging: 100mg
Price: $134
Updated: 2021/12/16

Apolloscientific

Product number: OR907958
Product name: 3-bromofuran-2-carboxylicacid
Purity: 95%
Packaging: 250mg
Price: $275
Updated: 2021/12/16

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3-Bromofuran-2-carboxylic acid Chemical Properties,Usage,Production

Uses

3-Bromo-2-furoic Acid is an intermediate in the synthesis of selective α4β2 nicotinic acetylcholine receptor agonists used for the treatment of cognitive disorders.

Synthesis

14757-78-9

14903-90-3

General procedure for the synthesis of 3-bromofuran-2-carboxylic acid from 3-bromofuran-2-carbaldehyde: A) To a solution of tert-butanol (250 mL) containing 3-bromofuran-2-carboxaldehyde (25.0 g) and 2-methyl-2-butene (45.4 mL) was added slowly and dropwise at room temperature a mixed solution prepared from 80% sodium chlorite (40.5 g) and sodium dihydrogen phosphate (51.5 g) in water (350 mL). The reaction mixture was stirred overnight and acidified by the addition of 1 M hydrochloric acid (300 mL), followed by extraction with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was washed with hexane/ethyl acetate (5/1, v/v) and recrystallized from the target product 3-bromofuran-2-carboxylic acid (20.3 g) by hexane/ethyl acetate solvent mixture. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 6.66 (1H, d, J=1.9 Hz), 7.58 (1H, d, J=1.9 Hz).

References

[1] Patent: US2013/137675, 2013, A1. Location in patent: Paragraph 0598

3-Bromofuran-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromofuran-2-carboxylic acid Suppliers

Belgium 1 China 82 India 2 United States 4 Global 89

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View Lastest Price from 3-Bromofuran-2-carboxylic acid manufacturers

Career Henan Chemical Co

Product: 3-BROMO-2-FUROIC ACID 14903-90-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-02

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