3-Bromofuran-2-carboxylic acid
- Product Name
- 3-Bromofuran-2-carboxylic acid
- CAS No.
- 14903-90-3
- Chemical Name
- 3-Bromofuran-2-carboxylic acid
- Synonyms
- 3-bromo-2-furanoic acid;3-Bromofuran-2-carboxylic acid;3-bromo-2-furancarboxylic acid;2-Furancarboxylic acid,3-broMo-
- CBNumber
- CB31466466
- Molecular Formula
- C5H3BrO3
- Formula Weight
- 190.98
- MOL File
- 14903-90-3.mol
3-Bromofuran-2-carboxylic acid Property
- Melting point:
- 127-129 °C
- Boiling point:
- 278.0±25.0 °C(Predicted)
- Density
- 1.891±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- soluble in Chloroform, DCM, Ethyl Acetate
- form
- Solid
- pka
- 2.77±0.20(Predicted)
- color
- Light Brown
- InChI
- InChI=1S/C5H3BrO3/c6-3-1-2-9-4(3)5(7)8/h1-2H,(H,7,8)
- InChIKey
- UZBGSJZFBUOJNE-UHFFFAOYSA-N
- SMILES
- O1C=CC(Br)=C1C(O)=O
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-26-36/37/39
- HS Code
- 2932190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B682665
- Product name
- 3-Bromo-2-furoicAcid
- Packaging
- 5g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- Z5464
- Product name
- 3-Bromofuran-2-carboxylicacid
- Packaging
- 100mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- OR907958
- Product name
- 3-bromofuran-2-carboxylicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 2H21-9-0K
- Product name
- 3-Bromofuran-2-carboxylicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $440
- Updated
- 2021/12/16
- Product number
- OR907958
- Product name
- 3-bromofuran-2-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $445
- Updated
- 2021/12/16
3-Bromofuran-2-carboxylic acid Chemical Properties,Usage,Production
Uses
3-Bromo-2-furoic Acid is an intermediate in the synthesis of selective α4β2 nicotinic acetylcholine receptor agonists used for the treatment of cognitive disorders.
Synthesis
14757-78-9
14903-90-3
General procedure for the synthesis of 3-bromofuran-2-carboxylic acid from 3-bromofuran-2-carbaldehyde: A) To a solution of tert-butanol (250 mL) containing 3-bromofuran-2-carboxaldehyde (25.0 g) and 2-methyl-2-butene (45.4 mL) was added slowly and dropwise at room temperature a mixed solution prepared from 80% sodium chlorite (40.5 g) and sodium dihydrogen phosphate (51.5 g) in water (350 mL). The reaction mixture was stirred overnight and acidified by the addition of 1 M hydrochloric acid (300 mL), followed by extraction with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was washed with hexane/ethyl acetate (5/1, v/v) and recrystallized from the target product 3-bromofuran-2-carboxylic acid (20.3 g) by hexane/ethyl acetate solvent mixture. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 6.66 (1H, d, J=1.9 Hz), 7.58 (1H, d, J=1.9 Hz).
References
[1] Patent: US2013/137675, 2013, A1. Location in patent: Paragraph 0598
3-Bromofuran-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromofuran-2-carboxylic acid Suppliers
- Tel
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- Country
- Belgium
- ProdList
- 6293
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View Lastest Price from 3-Bromofuran-2-carboxylic acid manufacturers
- Product
- 3-BROMO-2-FUROIC ACID 14903-90-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-02