FMOC-L-PIPECOLIC ACID
- Product Name
- FMOC-L-PIPECOLIC ACID
- CAS No.
- 86069-86-5
- Chemical Name
- FMOC-L-PIPECOLIC ACID
- Synonyms
- FMOC-PIP-OH;Fmoc-L-PIPE;FMOC-L-PIP-OH;FMOC-HOPRO-OH;FMOC-PIC(2)-OH;FMOC-HOMOPRO-OH;S)-PIPERIDINE-1;FMOC-HOMOPROLINE;FMO-L-HOMOPROLINE;FMOC-B-HOMO-PRO-OH
- CBNumber
- CB3146761
- Molecular Formula
- C21H21NO4
- Formula Weight
- 351.4
- MOL File
- 86069-86-5.mol
FMOC-L-PIPECOLIC ACID Property
- Melting point:
- 149-153
- Boiling point:
- 561.6±43.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 3.97±0.20(Predicted)
- color
- White to Light yellow
- optical activity
- [α]22/D 23°, c = 1 in DMF
- BRN
- 4718405
- CAS DataBase Reference
- 86069-86-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 706434
- Product name
- (S)-N-Fmoc-piperidine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $37.54
- Updated
- 2025/07/31
- Product number
- 706434
- Product name
- (S)-N-Fmoc-piperidine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $158
- Updated
- 2025/07/31
- Product number
- F0938
- Product name
- (S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-piperidinecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- F0938
- Product name
- (S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-piperidinecarboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $121
- Updated
- 2025/07/31
- Product number
- F679748
- Product name
- Fmoc-L-pipecolicAcid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
FMOC-L-PIPECOLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
peptide synthesis
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
102774-86-7
3105-95-1
101555-63-9
The general procedure for the synthesis of (R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid from the compound (CAS: 102774-86-7) and L-2-piperidinic acid is as follows: 1. L-piperidine acid (3.6 g, 38.7 mmol) was dissolved in 40 mL of 10% aqueous sodium carbonate solution in a round-bottomed flask and stirred at room temperature for 5 min. 2. Fmoc-OSu (8.5 g, 34.8 mmol) dissolved in 35 mL of dioxane was added to the above solution and the reaction mixture was stirred overnight. 3. After completion of the reaction, water was added and the aqueous layer was extracted with ethyl acetate. 4. The aqueous layer was adjusted to pH=2 by adding concentrated hydrochloric acid and then extracted with ethyl acetate (3 x 40 mL). 5. The organic phases were combined, washed sequentially with 1N hydrochloric acid and saturated brine, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain a colorless oily liquid. 6. The oily liquid was dissolved in ether, cooled and precipitated as a fluffy white solid, washed with hexane and dried to afford (S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (8.2 g, 38.7 mmol, 83% yield). Product Characterization Data: - TLC (unfolding agent: hexane:EtOAc:TFA = 1:1:0.2): rf = 0.60 - HPLC (gradient A): retention time = 24.6-24.8 min - 1H NMR (300 MHz, CDCl3): δ 1.28-1.53 (m, 2H), 1.69-1.82 (m, 3H), 2.19-2.37 (m, 1H), 3.15 (t, 1H, J = 13.2 Hz), 4.05-4.33 (m, 2H), 4.37-4.49 (m, 2H), 4.76- 5.05 (m, 1H), 7.28-7.41 (m, 4H), 7.55-7.62 (m, 2H), 1.77 (s, 2H) - 13C NMR (75 MHz, CDCl3): δ 20.72, 24.70, 26.55, 41.94, 47.25, 54.19, 67.86, 119.97, 125.08, 127.07, 127.68, 141.33, 143.89, 156.65, 177.36 - MS (ESI): m/z 352.66 [M + H]+, calculated 352.40 [M + H]+
References
[1] Patent: WO2013/91900, 2013, A1. Location in patent: Page/Page column 41
FMOC-L-PIPECOLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from FMOC-L-PIPECOLIC ACID manufacturers
- Product
- FMOC-L-PIPECOLIC ACID 86069-86-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15