FMOC-D-PIPECOLIC ACID

Product Name: FMOC-D-PIPECOLIC ACID
CAS No.: 101555-63-9
Chemical Name: FMOC-D-PIPECOLIC ACID
Synonyms: Fmoc-D-PIPE;FMOC-D-PIP-OH;FMOC-D-HOPRO-OH;(R)-PIPERIDINE-1;FMOC-D-PIC(2)-OH;FMOC-D-HOMOPRO-OH;FMOC-D-HOMOPROLINE;RARECHEM AR PA 0006;FMOC-D-PIPECOLIC ACID;Fmoc-D-Pip-OH
CBNumber: CB5186686
Molecular Formula: C21H21NO4
Formula Weight: 351.4
MOL File: 101555-63-9.mol

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FMOC-D-PIPECOLIC ACID Property

Melting point:: 149-153°C
Boiling point:: 561.6±43.0 °C(Predicted)
Density: 1.293±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
pka: 3.97±0.20(Predicted)
form: Solid
color: White to pale brown
optical activity: 20.768°(C=0.01g/ml DMF)
BRN: 5485101
CAS DataBase Reference: 101555-63-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
RIDADR: 3077
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 706469
Product name: (R)-N-Fmoc-piperidine-2-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $43.5
Updated: 2023/06/20

Sigma-Aldrich

Product number: 706469
Product name: (R)-N-Fmoc-piperidine-2-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $147
Updated: 2023/01/07

TCI Chemical

Product number: F0937
Product name: (R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-piperidinecarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: F0937
Product name: (R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-piperidinecarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $178
Updated: 2025/07/31

TRC

Product number: F472520
Product name: (R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylicAcid
Packaging: 2.5g
Price: $120
Updated: 2021/12/16

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FMOC-D-PIPECOLIC ACID Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic Acid is a building block used as a reactant in the preparation cyclic tetrapeptide derivatives as histone deacetylase inhibitors and antitumor agents.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

102774-86-7

3105-95-1

101555-63-9

The general procedure for the synthesis of (R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid from the compound (CAS: 102774-86-7) and L-2-piperidinic acid is as follows: 1. L-piperidine acid (3.6 g, 38.7 mmol) was dissolved in 40 mL of 10% sodium carbonate solution in a round-bottomed flask and stirred at room temperature for 5 min. 2. Fmoc-OSu (8.5 g, 34.8 mmol) dissolved in 35 mL of dioxane was added to the above solution and the reaction mixture was stirred overnight. 3. Upon completion of the reaction, water was added and the aqueous layer was extracted with ethyl acetate. 4. The aqueous layer was acidified to pH=2 by adding concentrated hydrochloric acid. 5. The acidified aqueous layer was extracted with ethyl acetate (3 x 40 mL). 6. 6. The organic phases were combined and washed sequentially with 1N HCl and brine, then dried with anhydrous magnesium sulfate and concentrated in vacuum to obtain a colorless oily liquid. 7. The oily liquid was dissolved in ether and cooled to give a fluffy white solid, which was washed with hexane and dried to give (S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (8.2 g, 38.7 mmol, 83% yield). Product characterization data: - TLC (hexane:EtOAc:TFA = 1:1:0.2): rf = 0.60 - HPLC (gradient A) retention time = 24.6-24.8 min - 1H NMR (300 MHz, CDCl3) δ = 1.28-1.53 (m, 2H), 1.69-1.82 (m, 3H), 2.19-2.37 (m, 1H), 3.15 (t, 1H, J = 13.2 Hz), 4.05-4.33 (m, 2H), 4.37-4.49 (m, 2H), 4.76- 5.05 (m, 1H), 7.28-7.41 (m, 4H), 7.55-7.62 (m, 2H), 1.77 (s, 2H). - 13C NMR (75 MHz, CDCl3) δ = 20.72, 24.70, 26.55, 41.94, 47.25, 54.19, 67.86, 119.97, 125.08, 127.07, 127.68, 141.33, 143.89, 156.65, 177.36. - MS (ESI) m/z: 352.66 [M + H]+, calculated: 352.40 [M + H]+.

References

[1] Patent: WO2013/91900, 2013, A1. Location in patent: Page/Page column 41

FMOC-D-PIPECOLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-D-PIPECOLIC ACID Suppliers

Americas 1 China 110 Europe 3 Germany 6 India 3 Japan 3 South Korea 1 Switzerland 2 United Kingdom 6 United States 24 Global 159

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Tel: 021-67121386
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Wuhan Chemwish Technology Co., Ltd

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Shanghai Chiral Chemicals Inc.

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Tel: 021-54306202 13764082696
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Chemsky (shanghai) International Co.,Ltd

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View Lastest Price from FMOC-D-PIPECOLIC ACID manufacturers

Career Henan Chemical Co

Product: FMOC-D-PIPECOLIC ACID 101555-63-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-11

101555-63-9, FMOC-D-PIPECOLIC ACIDRelated Search:

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(R)-1-FMoc-piperidine-2-carboxylic acid

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(R)-PIPERIDINE-1

2-DICARBOXYLIC ACID 1-(9H-FLUOREN-9-YLMETHYL) ESTER

Fmoc-D-PIPE

2-[9H-fluoren-9-ylmethoxy(oxo)methyl]-2-piperidinecarboxylic acid

N-FMOC-(R)-PIPECOLINIC ACID

Fmoc-D-Piperidine-2-carboxylic acid

N-alpha-(9-Fluorenyloxycarbonyl)-piperidine-2S-carboxylicacid

(R)-Piperidine-2-carboxylic acid, N-FMOC protected

D-Pipecolinic acid, N-FMOC protected

NALPHA-9-Fluorenylmethoxycarbonyl-D-pipecolinic acid

(R)-N-Fmoc-piperidine-2-carboxylic acid, N-Fmoc-D-pipecolic acid

(R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

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D-1-FMOC-PIPECOLINIC ACID

(D)-N-FMOC-PIPECOLIC ACID

(D)-N-(9-FLUORENYLMETHYLOXYCARBONYL)PIPECOLIC ACID

FMOC-D-HOMOPROLINE

FMOC-D-HOMOPRO-OH

FMOC-D-HOPRO-OH

FMOC-D-PIC(2)-OH

FMOC-D-(+)-PIPECOLIC ACID

FMOC-D-PIPECOLIC ACID

FMOC-D-PIP-OH

FMOC-(R)-PIPECOLINIC ACID

FMOC-(R)-(+)-PIPERIDINE-2-CARBOXYLIC ACID

FMOC-(R)-PIPERIDINE-2-CARBOXYLIC ACID

(2R)-1-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]HEXAHYDROPYRIDINE-2-CARBOXYLIC ACID

(2R)-1-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]PIPERIDINE-2-CARBOXYLIC ACID

(R)-N-Fmoc-piperidine-2-carboxyL

(R)-1-Fmoc-2-piperidinecarboxylic Acid

1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-pipecolic Acid

1-Fmoc-D-pipecolic Acid

Fmoc-<sc>D</sc>-Pip-OH

(R)-N-Fmoc-piperidine-2-carboxylic acid

FMOC-D-PIPECOLIC ACID 98%

101555-63-9

Peptide Synthesis

Proline Derivatives

Specialty Synthesis

Unnatural Amino Acid Derivatives

chiral