5,7-dichlorothiazolo[5,4-d]pyrimidine

Product Name: 5,7-dichlorothiazolo[5,4-d]pyrimidine
CAS No.: 13479-88-4
Chemical Name: 5,7-dichlorothiazolo[5,4-d]pyrimidine
Synonyms: 5,7-dichlorothiazolo[5,4-d]pyrimidine;Thiazolo[5,4-d]pyrimidine, 5,7-dichloro-;5,7-dichloro-[1,3]thiazolo[5,4-d]pyriMidine
CBNumber: CB31483436
Molecular Formula: C5HCl2N3S
Formula Weight: 206.05
MOL File: 13479-88-4.mol

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5,7-dichlorothiazolo[5,4-d]pyrimidine Property

Melting point:: 148.5-149.5 °C
Boiling point:: 281.2±22.0 °C(Predicted)
Density: 1.767±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 2 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
form: A solid
pka: -2.68±0.50(Predicted)
color: Light yellow to brown
InChI: InChI=1S/C5HCl2N3S/c6-3-2-4(11-1-8-2)10-5(7)9-3/h1H
InChIKey: XYBGDWLYHQAUQM-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=C2N=CSC2=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D436463
Product name: 5,7-Dichlorothiazolo[5,4-d]pyrimidine
Packaging: 100mg
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD142325
Product name: 5,7-Dichlorothiazolo[5,4-d]pyrimidine
Packaging: 100mg
Price: $142
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD142325
Product name: 5,7-Dichlorothiazolo[5,4-d]pyrimidine
Packaging: 50mg
Price: $82
Updated: 2021/12/16

AK Scientific

Product number: X9888
Product name: 5,7-Dichlorothiazolo[5,4-d]pyrimidine
Packaging: 250mg
Price: $262
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD142325
Product name: 5,7-Dichlorothiazolo[5,4-d]pyrimidine
Packaging: 250mg
Price: $282.5
Updated: 2021/12/16

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5,7-dichlorothiazolo[5,4-d]pyrimidine Chemical Properties,Usage,Production

Uses

5,7-Dichlorothiazolo[5,4-d]pyrimidine was used in studies to prepare Kinase inhibitors.

Synthesis

5082-82-6

13479-88-4

The general procedure for the synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine using thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione as starting material was as follows: a 10 mL round bottom flask was charged with intermediate 45.2 (100 mg, 0.59 mmol, 1.00 equiv.), N,N-diisopropylethylamine (DIEA, 0.5 mL) and phosphorus oxychloride (POCl3, 2 mL). The reaction mixture was stirred at 100 °C for 12 hours. After completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography to afford intermediate 45.3 (100 mg, 82% yield) as a yellow oil.

References

[1] Heterocycles, 2012, vol. 85, # 7, p. 1721 - 1726
[2] Patent: WO2015/48281, 2015, A1. Location in patent: Paragraph 00472; 00475
[3] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 168; 169
[4] Journal of the American Chemical Society, 1951, vol. 73, p. 3862

5,7-dichlorothiazolo[5,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-dichlorothiazolo[5,4-d]pyrimidine Suppliers

China 108 Germany 1 India 2 United Kingdom 1 United States 12 Global 124

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View Lastest Price from 5,7-dichlorothiazolo[5,4-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5,7-dichlorothiazolo[5,4-d]pyriMidine 13479-88-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 5,7-dichlorothiazolo[5,4-d]pyrimidine 13479-88-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 97%-99%
Supply Ability: as request
Release date: 2018-12-23

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13479-88-4

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