14(S),15(R)-EPOXY-(5Z,8Z,11Z)-EICOSATRIENOIC ACID

14(S),15(R)-EPOXY-(5Z,8Z,11Z)-EICOSATRIENOIC ACID Property

storage temp. 

−20°C

solubility 

Acetonitrile: Sparingly Soluble: 1-10 mg/ml
Ethanol: Slightly Soluble: 0.1-1 mg/ml

Safety

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 1170 3/PG 2

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

14(S),15(R)-EPOXY-(5Z,8Z,11Z)-EICOSATRIENOIC ACID Chemical Properties,Usage,Production

Uses

14R(15S)-EET (14R(15S)-EpETrE) is an oxylipin and a metabolite of Arachidonic acid (HY-109590)[1].

Definition

ChEBI: 14,15-Epoxy-5,8,11-eicosatrienoic acid is a long-chain fatty acid.

References

[1] Falck JR, et al. Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H337-49. DOI:10.1152/ajpheart.00831.2001
[2] B E DAIKH. Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 3: 1427-1433.