ChemicalBook > CAS DataBase List > 4-HYDROXY-6-METHOXYQUINOLINE

4-HYDROXY-6-METHOXYQUINOLINE

Product Name: 4-HYDROXY-6-METHOXYQUINOLINE
CAS No.: 13788-72-2
Chemical Name: 4-HYDROXY-6-METHOXYQUINOLINE
Synonyms: 6-methoxy-4-quinolone;6-METHOXYQUINOLIN-4-OL;6-METHOXY-4-QUINOLINOL;6-Methoxyquinolin-4(1H);6-methoxy-3H-quinolin-4-one;6-METHOXYQUINOLIN-4(1H)-ONE;6-methoxy-1H-quinolin-4-one;6-METHOXY-4(1H)-QUINOLINONE;4-HYDROXY-6-METHOXYQUINOLINE;4(1H)-Quinolinone, 6-methoxy-
CBNumber: CB3149777
Molecular Formula: C10H9NO2
Formula Weight: 175.18
MOL File: 13788-72-2.mol

Less

4-HYDROXY-6-METHOXYQUINOLINE Property

Melting point:: 251-252℃
Boiling point:: 322℃
Density: 1.199
Flash point:: 148℃
storage temp.: Store at room temperature
pka: 3.07±0.50(Predicted)
Appearance: White to off-white Solid

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

Less

N-Bromosuccinimide Price

TRC

Product number: M323623
Product name: 6-Methoxyquinolin-4(1H)-one
Packaging: 500mg
Price: $175
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0976293
Product name: 6-METHOXY-1,4-DIHYDROQUINOLIN-4-ONE
Purity: 95.00%
Packaging: 5MG
Price: $495.61
Updated: 2021/12/16

AK Scientific

Product number: CS-0044213
Product name: 6-Methoxyquinolin-4(1H)-one
Packaging: 10g
Price: $64
Updated: 2021/12/16

AK Scientific

Product number: CS-0044213
Product name: 6-Methoxyquinolin-4(1H)-one
Packaging: 25g
Price: $139
Updated: 2021/12/16

Matrix Scientific

Product number: 144080
Product name: 6-Methoxyquinolin-4(1H)-one
Purity: 95%
Packaging: 25g
Price: $1599
Updated: 2021/12/16

Less

4-HYDROXY-6-METHOXYQUINOLINE Chemical Properties,Usage,Production

Synthesis

25063-43-8

13788-72-2

1. 4-Methoxyaniline (1.27 g) and 5-methoxymethylene-2,2-dimethyl-[1,3]dioxolane-4,6-dione (1.82 g) were dissolved in 2-propanol (40 mL), and the reaction was stirred for 2 hours at 50°C. The reaction was completed by distillation under reduced pressure. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was washed with ether to afford 5-[(4-methoxyphenylamino)methylene]-2,2-dimethyl-[1,3]dioxolane-4,6-dione (1.98 g, 73% yield). 2. 5-[(4-methoxyphenylamino)methylene]-2,2-dimethyl-[1,3]dioxolane-4,6-dione (1.28 g) and biphenyl (5.2 g) were suspended in diphenyl ether (20 mL) and the reaction was stirred at 220 °C for 1 hour. The reaction mixture was purified by column chromatography in methanol-chloroform system to afford 6-methoxy-1H-quinolin-4-one (398 mg, 49% yield). 3. 6-Methoxy-1H-quinolin-4-one (398 mg) was suspended in diisopropylethylamine (3 mL), phosphorus trichloride (1 mL) was added, and the reaction was stirred at 100 °C for 1 hour. After completion of the reaction, water was added under cooling in an ice bath and the aqueous layer was neutralized with aqueous sodium bicarbonate. The organic layer was extracted with ethyl acetate, the ethyl acetate layer was washed with water and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by column chromatography in acetone-chloroform system to give 4-chloro-6-methoxyquinoline (375 mg, 42% yield).

References

[1] Synthetic Communications, 1985, vol. 15, # 2, p. 125 - 134
[2] Synlett, 2009, # 11, p. 1847 - 1851
[3] Synlett, 2007, # 14, p. 2205 - 2208
[4] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 42
[5] Advanced Synthesis and Catalysis, 2010, vol. 352, # 14-15, p. 2445 - 2449

4-HYDROXY-6-METHOXYQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-HYDROXY-6-METHOXYQUINOLINE Suppliers

China 54 Germany 1 United States 5 Global 60

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shanghai AmasPharm Co., Ltd.

Tel: 021-54540637 18621091017
Fax: 021-34978309
Email: sales@amaspharm.com
Country: China
ProdList: 781
Advantage: 62

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Chiba Pharmaceutical Science and technology Co, Ltd.

Tel: 0531-81313138 13066006660
Fax: QQ: 3366077777
Email: chibapharm@foxmail.com
Country: China
ProdList: 3991
Advantage: 55

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.

Tel: 02161555100
Fax: -
Country: China
ProdList: 820
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Lanzhou HuaHao Pharmaceutical Co., Ltd.

Tel: 18189674620
Email: 761137152@qq.com
Country: China
ProdList: 489
Advantage: 55

Quzhou AMK BioTech Co., Ltd

Tel: 0570-3081766 18357083060
Fax: 0570-3072337
Email: sales@qzamkbio.com
Country: China
ProdList: 1051
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8645
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Zhengzhou Edward Biology Co.,Ltd

Tel: 0371-63682289 15538176268
Fax: QQ：1875164801
Email: jacschem@163.com
Country: China
ProdList: 9926
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 18151111370
Email: 1046215251@qq.com
Country: China
ProdList: 5999
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Ningbo jinuo chemical co., LTD

Tel: 0574-87314919 057487319282
Email: info@nbinno.com
Country: China
ProdList: 7047
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Shanghai Weishukur Medical Technology Co., LTD

Tel: 15250615384
Email: 316228842@qq.com
Country: China
ProdList: 319
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 9967
Advantage: 58

Henan Dobe Chemical Co. , Ltd.

Tel: 0370-6999054 17550096163
Email: 3189729795@qq.com
Country: China
ProdList: 7172
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188 13327728092
Email: sales@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

Honghanyanxin Pharm

Tel: 0551-62626652 19334025048
Email: sales-honghanyanxin@aliyun.com
Country: China
ProdList: 1164
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-029-81148929 17791530722
Email: 1049@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Zhuhai Aobokai Biomedical Technology Co., Ltd.

Tel: 400-0628126 15697567703
Email: sales-team@aobchem.com.cn
Country: China
ProdList: 50000
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 14580
Advantage: 58

Nanjing Bicbiotechnology Co., Ltd

Tel: +86-2552131256 +86-18251840740
Email: sales@bicbiotech.com
Country: China
ProdList: 5994
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49934
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Guangzhou Zhenhao Biotechnology Co., Ltd.

Tel: 13430395027
Country: CHINA
ProdList: 115
Advantage: 58

Guangzhou Zhipuhui Technology Co., Ltd

Tel: 18933933667
Country: CHINA
ProdList: 183
Advantage: 58

Guangzhou Huiran Biochemical Technology Co., Ltd.

Tel: 15817162434
Country: CHINA
ProdList: 134
Advantage: 58

13788-72-2, 4-HYDROXY-6-METHOXYQUINOLINERelated Search:

4-HYDROXY-6-METHOXYQUINOLINE 6-METHOXYQUINAZOLIN-4-OL Proquinolate 2,4-DIHYDROXY-6-METHOXYQUINOLINE Ciproquinate 4-HYDROXY-6-(TRIFLUOROMETHOXY)-2-(TRIFLUOROMETHYL)QUINOLINE ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE 6-METHOXY-2-METHYLQUINOLIN-4-OL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Decoquinate 4-HYDROXY-6-METHOXYQUINOLINE buquinolate 6-Methoxyquinoline 4-HYDROXYQUINOLINE CHEMBRDG-BB 5688348 6-(TRIFLUOROMETHOXY)-4-QUINOLINOL ETHYL 4-HYDROXY-6-(TRIFLUOROMETHOXY)QUINOLINE-3-CARBOXYLATE AURORA 17941

6-methoxy-1H-quinolin-4-one

6-methoxy-4-quinolone

6-METHOXY-4-QUINOLINOL

6-METHOXYQUINOLIN-4(1H)-ONE

6-METHOXYQUINOLIN-4-OL

6-METHOXY-4(1H)-QUINOLINONE

4-HYDROXY-6-METHOXYQUINOLINE

6-Methoxyquinolin-4(1H)

6-METHOXY-1,4-DIHYDROQUINOLIN-4-ONE

4(1H)-Quinolinone, 6-methoxy-

6-methoxy-3H-quinolin-4-one

13788-72-2