4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID
- Product Name
- 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID
- CAS No.
- 28027-16-9
- Chemical Name
- 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID
- Synonyms
- Nsc80675;AKOS BB-8879;BUTTPARK 20\09-62;3-CARBOXY-4-HYDROXY-6-METHOXYQUINOLINE;6-methoxy-4-oxo-1H-quinoline-3-carboxylic acid;4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID;4-hydroxy-6-methoxy-3-quinoline carboxylic acid;3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-
- CBNumber
- CB4294728
- Molecular Formula
- C11H9NO4
- Formula Weight
- 219.19
- MOL File
- 28027-16-9.mol
4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Property
- Melting point:
- 278-279 °C (decomp)
- Boiling point:
- 418.6±45.0 °C(Predicted)
- Density
- 1.444±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 0.74±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- CAS DataBase Reference
- 28027-16-9(CAS DataBase Reference)
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BBO000704
- Product name
- 4-Hydroxy-6-methoxyquinoline-3-carboxylic acid
- Packaging
- 1 g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- H617780
- Product name
- 4-Hydroxy-6-methoxyquinoline-3-carboxylicAcid
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FC150897
- Product name
- 3-Carboxy-4-hydroxy-6-methoxyquinoline
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 2704AB
- Product name
- 4-Hydroxy-6-methoxyquinoline-3-carboxylicacid
- Packaging
- 500mg
- Price
- $71
- Updated
- 2021/12/16
- Product number
- FC150897
- Product name
- 3-Carboxy-4-hydroxy-6-methoxyquinoline
- Packaging
- 100mg
- Price
- $76
- Updated
- 2021/12/16
4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
77156-78-6
28027-16-9
General procedure for the synthesis of 4-hydroxy-6-methoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate: ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate (17.8 g, 72 mmol) was suspended in 170 mL of aqueous 2 N sodium hydroxide solution, heated to 90 °C, and the reaction was maintained for 1.5 h. The mixture was cooled to room temperature and slowly poured into ice water. Upon completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and the pH was adjusted to 5 with 2 N hydrochloric acid.The precipitated solid was collected by filtration, washed with cold water and dried to give 4-hydroxy-6-methoxyquinoline-3-carboxylic acid (15.8 g, 72 mmol, 99% yield). The product was characterized by 1H-NMR (DMSO-d6): δ= 3.91 (s, 3H), 7.53 (dd, 1H), 7.64 (d, 1H), 7.82 (d, 1H), 8.80 (d, 1H), 13.63 (bs, 1H), 15.55 (s, 1H).Results of LC-MS analysis: retention time (Rt) = 1.20 min; Mass spectrum (MS): m/z = 220 [M+H]+.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 8, p. 794 - 796
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1204,1206
[3] Organic Syntheses, 1955, vol. Coll. Vol. III, p. 272
[4] Journal of the American Chemical Society, 1947, vol. 69, p. 1659,1660
[5] Journal of the Chemical Society, 1946, p. 1033,1035
4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Suppliers
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1998
- Advantage
- 58
- Tel
- 13524892556
- Fax
- (86) 21 51969655， QQ： 263541193
- sales-cn@potentpharm.com
- Country
- China
- ProdList
- 1011
- Advantage
- 55
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 13681854265
- info@moenpharm.com
- Country
- China
- ProdList
- 480
- Advantage
- 55
- Tel
- 0570-3081766 18357083060
- Fax
- 0570-3072337
- sales@qzamkbio.com
- Country
- China
- ProdList
- 1046
- Advantage
- 55