4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
- Product Name
- 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
- CAS No.
- 28027-17-0
- Chemical Name
- 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
- Synonyms
- NSC 86135;AURORA 17949;ine-3-carboxyL;BUTTPARK 20\09-64;4-Hydroxy-7-methoxyquinoL;7-methoxy-4-oxo-1H-quinoline-3-carboxylicaci;7-Methoxy-4-hydroxyquinoline-3-carboxylic acid;4-Hydroxy-7-methoxy-3-quinolinecarboxylic acid;4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID;7-methoxy-4-oxo-1H-quinoline-3-carboxylic acid
- CBNumber
- CB2672760
- Molecular Formula
- C11H9NO4
- Formula Weight
- 219.19
- MOL File
- 28027-17-0.mol
4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID Property
- Melting point:
- 0°C
- Boiling point:
- 0°C
- Density
- 1.444
- Flash point:
- 0°C
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 0.92±0.30(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H999863
- Product name
- 4-Hydroxy-7-methoxyquinoline-3-carboxylicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- H999863
- Product name
- 4-Hydroxy-7-methoxyquinoline-3-carboxylicAcid
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W5097
- Product name
- 4-Hydroxy-7-methoxyquinoline-3-carboxylicacid
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- 4H29-1-62
- Product name
- 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid
- Purity
- 97%
- Packaging
- 5G
- Price
- $96
- Updated
- 2021/12/16
- Product number
- W5097
- Product name
- 4-Hydroxy-7-methoxyquinoline-3-carboxylicacid
- Packaging
- 5g
- Price
- $147
- Updated
- 2021/12/16
4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
63463-15-0
28027-17-0
General procedure for the synthesis of 4-hydroxy-7-methoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate: ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate (4.40 g, 17.80 mmol) was dissolved in 2 M NaOH solution and hydrolyzed by refluxing the reaction for 1 h at 110 °C. The mixture was cooled to room temperature and acidified with 2 M HCl solution. After completion of the reaction, the mixture was cooled to room temperature and acidified to pH 3-4 with 2 M HCl solution.After acidification, the precipitated white precipitate was collected by filtration, washed with water and dried to afford the target product 4-hydroxy-7-methoxyquinoline-3-carboxylic acid (2.50 g, 63% yield) with a melting point of 272 °C (literature value: Lauer et al., 1946, 257-260 °C). NMR hydrogen spectrum (400 MHz, DMSO-d6) δ: 3.90 (3H, s, OCH3), 7.17 (1H, dd, J = 2.4, 9.0 Hz, H-6), 7.29 (1H, d, J = 2.3 Hz, H-8), 8.16 (1H, d, J = 9.0 Hz, H-5), 8.72 (1H, s, H-2). 13.68 (1H, s, Ar-OH), 15.50 (1H, bs, -COOH). NMR carbon spectrum (100 MHz, DMSO-d6) δ: 56.3 (Ar-OCH3), 101.1 (C-3), 107.8 (C-8), 116.6 (C-4a), 118.9 (C-6), 127.3 (C-5), 142.0 (C-2), 145.0 (C-8a), 163.8 (C-4). 166.9 (C-7), 178.1 (COOH).
References
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 13, p. 3738 - 3748
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1268
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4918 - 4926
[4] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 5, p. 821 - 824
[5] Patent: US6110929, 2000, A
4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID manufacturers
- Product
- 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID 28027-17-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09