ChemicalBook > CAS DataBase List > 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID

4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID

Product Name: 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
CAS No.: 28027-17-0
Chemical Name: 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
Synonyms: NSC 86135;AURORA 17949;ine-3-carboxyL;BUTTPARK 20\09-64;4-Hydroxy-7-methoxyquinoL;7-methoxy-4-oxo-1H-quinoline-3-carboxylicaci;7-Methoxy-4-hydroxyquinoline-3-carboxylic acid;4-Hydroxy-7-methoxy-3-quinolinecarboxylic acid;4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID;7-methoxy-4-oxo-1H-quinoline-3-carboxylic acid
CBNumber: CB2672760
Molecular Formula: C11H9NO4
Formula Weight: 219.19
MOL File: 28027-17-0.mol

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4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID Property

Melting point:: 0°C
Boiling point:: 0°C
Density: 1.444
Flash point:: 0°C
storage temp.: Inert atmosphere,Room Temperature
pka: 0.92±0.30(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22
Safety Statements: 22-24/25
Hazard Note: Irritant
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H999863
Product name: 4-Hydroxy-7-methoxyquinoline-3-carboxylicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: H999863
Product name: 4-Hydroxy-7-methoxyquinoline-3-carboxylicAcid
Packaging: 500mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: W5097
Product name: 4-Hydroxy-7-methoxyquinoline-3-carboxylicacid
Packaging: 1g
Price: $77
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-1-62
Product name: 4-Hydroxy-7-methoxyquinoline-3-carboxylic acid
Purity: 97%
Packaging: 5G
Price: $96
Updated: 2021/12/16

AK Scientific

Product number: W5097
Product name: 4-Hydroxy-7-methoxyquinoline-3-carboxylicacid
Packaging: 5g
Price: $147
Updated: 2021/12/16

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4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

63463-15-0

28027-17-0

General procedure for the synthesis of 4-hydroxy-7-methoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate: ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate (4.40 g, 17.80 mmol) was dissolved in 2 M NaOH solution and hydrolyzed by refluxing the reaction for 1 h at 110 °C. The mixture was cooled to room temperature and acidified with 2 M HCl solution. After completion of the reaction, the mixture was cooled to room temperature and acidified to pH 3-4 with 2 M HCl solution.After acidification, the precipitated white precipitate was collected by filtration, washed with water and dried to afford the target product 4-hydroxy-7-methoxyquinoline-3-carboxylic acid (2.50 g, 63% yield) with a melting point of 272 °C (literature value: Lauer et al., 1946, 257-260 °C). NMR hydrogen spectrum (400 MHz, DMSO-d6) δ: 3.90 (3H, s, OCH3), 7.17 (1H, dd, J = 2.4, 9.0 Hz, H-6), 7.29 (1H, d, J = 2.3 Hz, H-8), 8.16 (1H, d, J = 9.0 Hz, H-5), 8.72 (1H, s, H-2). 13.68 (1H, s, Ar-OH), 15.50 (1H, bs, -COOH). NMR carbon spectrum (100 MHz, DMSO-d6) δ: 56.3 (Ar-OCH3), 101.1 (C-3), 107.8 (C-8), 116.6 (C-4a), 118.9 (C-6), 127.3 (C-5), 142.0 (C-2), 145.0 (C-8a), 163.8 (C-4). 166.9 (C-7), 178.1 (COOH).

References

[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 13, p. 3738 - 3748
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1268
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4918 - 4926
[4] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 5, p. 821 - 824
[5] Patent: US6110929, 2000, A

4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID 28027-17-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

28027-17-0, 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACIDRelated Search:

4-HYDROXY-6-PHENYLPYRIDINE-2-CARBOXYLIC ACID 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 7-Methoxy-4-quinolinol 4-Hydroxy-5-methoxyquinoline- 3-carboxylic acid 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID (S)-1-Boc-3-methylpiperazine 4-Hydroxy-8-methoxyquinoline-3-carboxylic acid ,95%,4-HYDROXY-8-METHOXYQUINOLINE-3-CARBOXYLIC ACID Ciproquinate Proquinolate 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID Decoquinate buquinolate 7-methoxyquinoline 4-HYDROXY-7-METHOXYQUINOLINE 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid 7-BENZYLOXY-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 8-HYDROXY-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLIC ACID ETHYL ESTER 9-hydroxy-2,3-dihydro[1,4]dioxino[2,3-g]quinoline-8-carboxylic acid

4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID

AURORA 17949

BUTTPARK 20\09-64

4-keto-7-methoxy-1H-quinoline-3-carboxylic acid

7-methoxy-4-oxo-1H-quinoline-3-carboxylic acid

7-Methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

4-Hydroxy-7-methoxy-3-quinolinecarboxylic acid

7-Methoxy-4-hydroxyquinoline-3-carboxylic acid

NSC 86135

4-Hydroxy-7-Methoxyquinoline-3-caroboxylic acid

4-Hydroxy-7-methoxyquinoL

ine-3-carboxyL

3-Quinolinecarboxylic acid, 4-hydroxy-7-methoxy-

7-methoxy-4-oxo-1H-quinoline-3-carboxylicaci

4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ISO 9001：2015 REACH

28027-17-0

quinoline