7-methoxyquinoline
- Product Name
- 7-methoxyquinoline
- CAS No.
- 4964-76-5
- Chemical Name
- 7-methoxyquinoline
- Synonyms
- 7-methoxyquinoline;Quinoline, 7-methoxy-
- CBNumber
- CB31356525
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 4964-76-5.mol
7-methoxyquinoline Property
- Boiling point:
- 143-145 °C(Press: 11 Torr)
- Density
- 1.130±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform
- form
- Oil
- pka
- 5.26±0.14(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C10H9NO/c1-12-9-5-4-8-3-2-6-11-10(8)7-9/h2-7H,1H3
- InChIKey
- IVHJSNNMKJWPFW-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=C(OC)C=2)C=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M267405
- Product name
- 7-Methoxyquinoline
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 11713
- Product name
- 7-Methoxyquinoline
- Packaging
- 25mg
- Price
- $860
- Updated
- 2021/12/16
- Product number
- W6515
- Product name
- 7-Methoxyquinoline
- Packaging
- 25g
- Price
- $1224
- Updated
- 2021/12/16
- Product number
- 4964765
- Product name
- 7-Methoxyquinoline
- Packaging
- 25g
- Price
- $1027.69
- Updated
- 2021/12/16
- Product number
- CD11116591
- Product name
- 7-Methoxyquinoline
- Purity
- 98%
- Packaging
- 5g
- Price
- $233
- Updated
- 2021/12/16
7-methoxyquinoline Chemical Properties,Usage,Production
Chemical Properties
Yellow Oil
Uses
7-Methoxyquinoline (cas# 4964-76-5) is a compound useful in organic synthesis.
Synthesis
580-20-1
74-88-4
4964-76-5
General procedure for the synthesis of 7-methoxyquinoline from 7-hydroxyquinoline and iodomethane: 7-hydroxyquinoline (8 g, 55.11 mmol) was added to a solution of sodium hydride (5.5 g, 137.50 mmol, 60% pure) in N,N-dimethylformamide (150 mL). The reaction mixture was stirred in a water/ice bath at 0 °C for 1 hour. Subsequently, iodomethane (7.84 g, 55.23 mmol) was added and the reaction solution was continued to be stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of a water/ice mixture (700 mL) and extracted with ethyl acetate (3 x 200 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography, using a petroleum ether solution of 6% ethyl acetate as eluent to give 7-methoxyquinoline as a red oil (5.5 g). The product was analyzed by LC-MS showing [M+H]+ peak of 160.0. 1H-NMR (300 MHz, CDCl3) data were as follows: δ 8.84-8.86 (m, 1H), 8.07-8.11 (m, 1H), 7.70-7.73 (t, J = 5.1 Hz, 1H), 7.44 (d, J = 2.4 Hz, 1H). 7.20-7.30 (m, 2H), 3.95 (s, 3H). Case No. BIOE0009-401-PC.
References
[1] Synthetic Communications, 2000, vol. 30, # 2, p. 367 - 375
[2] Patent: WO2012/94462, 2012, A2. Location in patent: Page/Page column 82
[3] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 278
[4] Patent: WO2012/58125, 2012, A1. Location in patent: Page/Page column 115; 116
7-methoxyquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-methoxyquinoline manufacturers
- Product
- 7-methoxyquinoline 4964-76-5
- Price
- US $1.00-100.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 300KG
- Release date
- 2024-08-16
- Product
- 7-methoxyquinoline 4964-76-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09