ChemicalBook > CAS DataBase List > 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID

4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID

Product Name: 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID
CAS No.: 28027-16-9
Chemical Name: 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID
Synonyms: Nsc80675;AKOS BB-8879;BUTTPARK 20\09-62;3-CARBOXY-4-HYDROXY-6-METHOXYQUINOLINE;6-methoxy-4-oxo-1H-quinoline-3-carboxylic acid;4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID;4-hydroxy-6-methoxy-3-quinoline carboxylic acid;3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-
CBNumber: CB4294728
Molecular Formula: C11H9NO4
Formula Weight: 219.19
MOL File: 28027-16-9.mol

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4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Property

Melting point:: 278-279 °C (decomp)
Boiling point:: 418.6±45.0 °C(Predicted)
Density: 1.444±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 0.74±0.30(Predicted)
Appearance: Off-white to light yellow Solid
CAS DataBase Reference: 28027-16-9(CAS DataBase Reference)

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000704
Product name: 4-Hydroxy-6-methoxyquinoline-3-carboxylic acid
Packaging: 1 g
Price: $179
Updated: 2025/07/31

TRC

Product number: H617780
Product name: 4-Hydroxy-6-methoxyquinoline-3-carboxylicAcid
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150897
Product name: 3-Carboxy-4-hydroxy-6-methoxyquinoline
Packaging: 250mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: 2704AB
Product name: 4-Hydroxy-6-methoxyquinoline-3-carboxylicacid
Packaging: 500mg
Price: $71
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150897
Product name: 3-Carboxy-4-hydroxy-6-methoxyquinoline
Packaging: 100mg
Price: $76
Updated: 2021/12/16

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4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

77156-78-6

28027-16-9

General procedure for the synthesis of 4-hydroxy-6-methoxyquinoline-3-carboxylic acid from ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate: ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate (17.8 g, 72 mmol) was suspended in 170 mL of aqueous 2 N sodium hydroxide solution, heated to 90 °C, and the reaction was maintained for 1.5 h. The mixture was cooled to room temperature and slowly poured into ice water. Upon completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and the pH was adjusted to 5 with 2 N hydrochloric acid.The precipitated solid was collected by filtration, washed with cold water and dried to give 4-hydroxy-6-methoxyquinoline-3-carboxylic acid (15.8 g, 72 mmol, 99% yield). The product was characterized by 1H-NMR (DMSO-d6): δ= 3.91 (s, 3H), 7.53 (dd, 1H), 7.64 (d, 1H), 7.82 (d, 1H), 8.80 (d, 1H), 13.63 (bs, 1H), 15.55 (s, 1H).Results of LC-MS analysis: retention time (Rt) = 1.20 min; Mass spectrum (MS): m/z = 220 [M+H]+.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 8, p. 794 - 796
[2] Journal of the American Chemical Society, 1946, vol. 68, p. 1204,1206
[3] Organic Syntheses, 1955, vol. Coll. Vol. III, p. 272
[4] Journal of the American Chemical Society, 1947, vol. 69, p. 1659,1660
[5] Journal of the Chemical Society, 1946, p. 1033,1035

4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACID Suppliers

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28027-16-9, 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLIC ACIDRelated Search:

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