2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL

Product Name: 2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL
CAS No.: 349-67-7
Chemical Name: 2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL
Synonyms: 2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL;Phenol, 2-methoxy-5-(trifluoromethyl)-
CBNumber: CB31499815
Molecular Formula: C8H7F3O2
Formula Weight: 192.14
MOL File: 349-67-7.mol

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2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL Property

Boiling point:: 104-105 °C(Press: 12 Torr)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 8.97±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2907199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M332240
Product name: 2-Methoxy-5-(trifluoromethyl)phenol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0357944
Product name: 2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL
Purity: 95.00%
Packaging: 250MG
Price: $376.95
Updated: 2021/12/16

Chemenu

Product number: CM183650
Product name: 2-methoxy-5-(trifluoromethyl)phenol
Purity: 98%
Packaging: 1g
Price: $464
Updated: 2021/12/16

Alichem

Product number: 349677
Product name: 2-Methoxy-5-(trifluoromethyl)phenol
Packaging: 250mg
Price: $489.6
Updated: 2021/12/16

Crysdot

Product number: CD12080373
Product name: 2-Methoxy-5-(trifluoromethyl)phenol
Purity: 98%
Packaging: 1g
Price: $491
Updated: 2021/12/16

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2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL Chemical Properties,Usage,Production

Synthesis

240139-82-6

349-67-7

The general procedure for the synthesis of 2-methoxy-5-trifluoromethylphenol from 2-methoxy-5-trifluoromethylphenylboronic acid was as follows: to a 100 mL round bottom flask was added [2-methoxy-5-(trifluoromethyl)phenyl]boronic acid (300 mg, 1.36 mmol, 1.00 eq.), ethanol (15 mL), and 30% hydrogen peroxide aqueous solution (2 mL). The reaction mixture was stirred at 80°C for 2 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure. Subsequently, water was added to dilute the reaction mixture. The mixture was washed with aqueous sodium sulfite and the aqueous layer was extracted with ethyl acetate and the organic layers were combined. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and finally concentrated under reduced pressure to give 250 mg (95% yield) of 2-methoxy-5-(trifluoromethyl)phenol as a colorless oil.

References

[1] Patent: WO2015/130957, 2015, A1. Location in patent: Page/Page column 85
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 12, p. 3089 - 3104

2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL Suppliers

China 29 India 2 Global 31

Cochemical Ltd.

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349-67-7, 2-METHOXY-5-(TRIFLUOROMETHYL)PHENOLRelated Search:

Phenol

2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL

Phenol, 2-methoxy-5-(trifluoromethyl)-

349-67-7