2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
- Product Name
- 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 208517-35-5
- Chemical Name
- 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Ethyl 2-(trifluoromethyl)nicotinate;2-Trifluoromethyl-nicotinic acid ethyl ester;ethyl 2-(trifluoroMethyl)pyridine-3-carboxylate;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
- CBNumber
- CB31500218
- Molecular Formula
- C9H8F3NO2
- Formula Weight
- 219.16
- MOL File
- 208517-35-5.mol
2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Property
- Boiling point:
- 235.8±40.0 °C(Predicted)
- Density
- 1.284±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.38±0.22(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E937090
- Product name
- Ethyl2-(Trifluoromethyl)nicotinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H23-3-18
- Product name
- Ethyl 2-(trifluoromethyl)pyridine-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $214
- Updated
- 2021/12/16
- Product number
- 4H23-3-18
- Product name
- Ethyl 2-(trifluoromethyl)pyridine-3-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 083416
- Product name
- Ethyl 2-(trifluoromethyl)nicotinate
- Purity
- 97%
- Packaging
- 1g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- 083416
- Product name
- Ethyl 2-(trifluoromethyl)nicotinate
- Purity
- 97%
- Packaging
- 5g
- Price
- $272
- Updated
- 2021/12/16
2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Yellow liquid
Synthesis
1146961-22-9
208517-35-5
In a 1 L single neck round bottom flask equipped with a magnetic stirrer and a reflux condenser, ethyl (2E,4E)-5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienoate (80.50 g, 303.8 mmol) was dissolved in a solvent mixture of methanol (700 mL) and 25% aqueous ammonia solution (240 mL). The reaction mixture was heated to 70 °C and maintained for 20 minutes. It was then cooled to room temperature and the methanol was removed by distillation under reduced pressure. The residue was diluted with water (200 mL) and extracted with ether (2 x 300 mL). The organic phases were combined, washed with saturated brine (200 mL), dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure to give 65.0 g of red oily crude product. The crude product was pure enough for subsequent reactions. For further purification, the crude product was filtered through a short silica gel column, followed by evaporation of the filtrate to give 59.9 g of light yellow flowing oil in 90% yield.
References
[1] Patent: WO2009/54742, 2009, A2. Location in patent: Page/Page column 13-14
2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER 208517-35-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27
- Product
- Ethyl 2-(trifluoromethyl)nicotinate 208517-35-5
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09