ChemicalBook > CAS DataBase List > 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER

Product Name: 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
CAS No.: 208517-35-5
Chemical Name: 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
Synonyms: Ethyl 2-(trifluoromethyl)nicotinate;2-Trifluoromethyl-nicotinic acid ethyl ester;ethyl 2-(trifluoroMethyl)pyridine-3-carboxylate;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
CBNumber: CB31500218
Molecular Formula: C9H8F3NO2
Formula Weight: 219.16
MOL File: 208517-35-5.mol

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2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Property

Boiling point:: 235.8±40.0 °C(Predicted)
Density: 1.284±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.38±0.22(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E937090
Product name: Ethyl2-(Trifluoromethyl)nicotinate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-3-18
Product name: Ethyl 2-(trifluoromethyl)pyridine-3-carboxylate
Purity: 97%
Packaging: 250mg
Price: $73
Updated: 2021/12/16

Matrix Scientific

Product number: 083416
Product name: Ethyl 2-(trifluoromethyl)nicotinate
Purity: 97%
Packaging: 1g
Price: $78
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-3-18
Product name: Ethyl 2-(trifluoromethyl)pyridine-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $214
Updated: 2021/12/16

Matrix Scientific

Product number: 083416
Product name: Ethyl 2-(trifluoromethyl)nicotinate
Purity: 97%
Packaging: 5g
Price: $272
Updated: 2021/12/16

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2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Yellow liquid

Synthesis

1146961-22-9

208517-35-5

In a 1 L single neck round bottom flask equipped with a magnetic stirrer and a reflux condenser, ethyl (2E,4E)-5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienoate (80.50 g, 303.8 mmol) was dissolved in a solvent mixture of methanol (700 mL) and 25% aqueous ammonia solution (240 mL). The reaction mixture was heated to 70 °C and maintained for 20 minutes. It was then cooled to room temperature and the methanol was removed by distillation under reduced pressure. The residue was diluted with water (200 mL) and extracted with ether (2 x 300 mL). The organic phases were combined, washed with saturated brine (200 mL), dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure to give 65.0 g of red oily crude product. The crude product was pure enough for subsequent reactions. For further purification, the crude product was filtered through a short silica gel column, followed by evaporation of the filtrate to give 59.9 g of light yellow flowing oil in 90% yield.

References

[1] Patent: WO2009/54742, 2009, A2. Location in patent: Page/Page column 13-14

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER manufacturers

Dideu Industries Group Limited

Product: 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER 208517-35-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-27

Career Henan Chemical Co

Product: Ethyl 2-(trifluoromethyl)nicotinate 208517-35-5
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

208517-35-5, 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTERRelated Search:

ETHYL STEARATE 2-(Trifluoromethyl)nicotinic acid Ethyl nicotinate 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER 1,8-Naphthyridine-3-carboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) ETHYL 5-CYANO-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE DIETHYL 3-AMINO-6-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2,5-DICARBOXYLATE ETHYL 2-CHLORO-3-CYANO-6-(TRIFLUOROMETHYL)-PYRIDINE-5-CARBOXYLATE RARECHEM AL BW 1871 ETHYL 5-(AMINO([(2,3,3-TRICHLOROALLANOYL)OXY]IMINO)METHYL)-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE RARECHEM AL BW 1646 BUTTPARK 82\12-87 ETHYL 5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 5-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-6-CARBOXYLIC ACID, ETHYL ESTER ETHYL 5-(AMINOCARBOTHIOYL)-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE ETHYL 5-CYANO-6-([2-(([(2,6-DICHLORO-4-PYRIDYL)AMINO]CARBONYL)AMINO)PHENYL]THIO)-2-(TRIFLUOROMETHYL)NICOTINATE 2-(TRIFLUOROMETHYL)-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ETHYL ESTER DIETHYL 2-METHYL-6-(TRIFLUOROMETHYL)PYRIDINE-3,5-DICARBOXYLATE

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER

2-Trifluoromethyl-nicotinic acid ethyl ester

Ethyl 2-(trifluoromethyl)nicotinate

ethyl 2-(trifluoroMethyl)pyridine-3-carboxylate

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH

208517-35-5

Building Blocks

Pyridine