tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate
- Product Name
- tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate
- CAS No.
- 221050-88-0
- Chemical Name
- tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate
- Synonyms
- tert-Butyl 4-(2-chloropyrimidin-4-yl);2-Chloro-4-(4-Boc-1-piperazinyl)pyriMidine;1-Boc-4-(2-chloropyrimidin-4-yl)piperazine;2-Chloro-4-[1-(4-tert-butoxycarbonyl)piperazinyl]pyrimidine;ert-butyl4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate;tert-Butyl 4-(2-Chloro-4-pyrimidinyl)-1-piperazinecarboxylate;tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate;4-(2-Chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(2-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB31501705
- Molecular Formula
- C13H19ClN4O2
- Formula Weight
- 298.77
- MOL File
- 221050-88-0.mol
tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Property
- Boiling point:
- 451.8±35.0 °C(Predicted)
- Density
- 1.253±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.51±0.31(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809673
- Product name
- tert-Butyl4-(2-Chloropyrimidin-4-yl)piperazine-1-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB125461
- Product name
- tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 194599
- Product name
- tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate
- Packaging
- 0.500g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- W4565
- Product name
- 1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine
- Packaging
- 10g
- Price
- $371
- Updated
- 2021/12/16
- Product number
- 194599
- Product name
- tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate
- Packaging
- 5g
- Price
- $460
- Updated
- 2021/12/16
tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
3934-20-1
57260-71-6
221050-88-0
General procedure for the synthesis of 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine from 2,4-dichloropyrimidine and N-BOC-piperazine: 2,4-dichloropyrimidine (2.0 g, 13.43 mmol) was accurately weighed and dissolved in N,N-dimethylformamide (DMF) (15 mL), followed by the addition of triethylamine (TEA) (2.72 g, 26.85 mmol) and 1-Boc piperazine (2.75 g, 14.77 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction endpoint was confirmed by thin layer chromatography (TLC) monitoring. The reaction mixture was slowly poured into 200 mL of ice water, at which point a large amount of white solid precipitated. The white solid was collected by filtration and washed with an appropriate solvent and finally dried to afford the target product 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine (3.8 g, 13.43 mmol).
References
[1] Patent: CN108503645, 2018, A. Location in patent: Paragraph 0117-0119
[2] Patent: US2009/163508, 2009, A1. Location in patent: Page/Page column 14
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1468 - 1478
[4] Organic Letters, 2018, vol. 20, # 2, p. 473 - 476
[5] Patent: WO2017/58503, 2017, A1. Location in patent: Page/Page column 419; 421; 422
tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate manufacturers
- Product
- 1-Boc-4-(2-ChloropyriMidin-4-yl)piperazine 221050-88-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15