YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER

Product Name: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER
CAS No.: 869198-95-8
Chemical Name: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER
Synonyms: 6-Boc-2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine;6-Boc-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-ylamine;tert-butyl 2-amino-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate;tert-butyl 2-aMino-7,8-dihydro-5H-pyrido[4,3-d]pyriMidine-6-carboxylate;2-Amino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid tert-butyl ester;2-AMino-7,8-dihydro-5H-pyrido[4,3-d]pyriMidine-6-carboxylic acid tert-butyl ester;YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER;PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER
CBNumber: CB31501927
Molecular Formula: C12H18N4O2
Formula Weight: 250.3
MOL File: 869198-95-8.mol

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YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER Property

Melting point:: 170-172°
Boiling point:: 443.7±55.0 °C(Predicted)
Density: 1.231
storage temp.: 2-8°C(protect from light)
pka: 4.18±0.20(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB144282
Product name: tert-Butyl 2-amino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144282
Product name: tert-Butyl 2-amino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Packaging: 500mg
Price: $140
Updated: 2021/12/16

Matrix Scientific

Product number: 046459
Product name: tert-Butyl 2-amino-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate
Purity: >95%
Packaging: 500mg
Price: $362
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144282
Product name: tert-Butyl 2-amino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Packaging: 2g
Price: $428
Updated: 2021/12/16

Matrix Scientific

Product number: 046459
Product name: tert-Butyl 2-amino-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate
Purity: >95%
Packaging: 1g
Price: $454
Updated: 2021/12/16

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YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Synthesis

157327-41-8

869198-95-8

1-Boc-3-[(dimethylamino)methylene]-4-oxopiperidine (7.64 g, 30.04 mmol) was used as starting material and dissolved in methanol (190 mL). To this solution, guanidine carbonate (21.65 g, 120.16 mmol) and sodium acetate trihydrate (32.70 g, 240.32 mmol) were added sequentially. The reaction mixture was heated to reflux and the reaction was continued for 17 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was diluted with water and mixed by vortexing for several minutes. The undissolved white solid was collected and washed sequentially with water and a small amount of cold ethyl acetate to give the final pyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid, 2-amino-7-1,8-dihydro-1,1-dimethylethyl ester (4.10 g, 55% yield).

References

[1] Patent: US9296747, 2016, B1. Location in patent: Page/Page column 22
[2] Patent: WO2005/105759, 2005, A1. Location in patent: Page/Page column 81

YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER Suppliers

China 78 Germany 1 India 1 United Kingdom 1 United States 7 Global 88

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View Lastest Price from YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER manufacturers

Career Henan Chemical Co

Product: YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER 869198-95-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

869198-95-8, YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTERRelated Search:

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Pyrido[2,3-b]pyrazine 1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE Pyrrolo[1,2-a]pyrazine PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE PYRIDO[2,3-D]PYRIMIDIN-4(1H)-ONE YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER Pyrido[4,3-d]pyrimidin-2-amine, 5,6,7,8-tetrahydro- (9CI) PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 7,8-DIHYDRO-2-(4-MORPHOLINYL)-, 1,1-DIMETHYLETHYL ESTER

YRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER

6-Boc-2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine

2-AMino-7,8-dihydro-5H-pyrido[4,3-d]pyriMidine-6-carboxylic acid tert-butyl ester

2-Amino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid tert-butyl ester

tert-butyl 2-aMino-7,8-dihydro-5H-pyrido[4,3-d]pyriMidine-6-carboxylate

6-Boc-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-ylamine

PYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLIC ACID, 2-AMINO-7,8-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER

tert-butyl 2-amino-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate

869198-95-8

Heterocycle-Pyrimidine series