ChemicalBook > CAS DataBase List > 4-CHLORO-6,7-DIFLUOROQUINAZOLINE

4-CHLORO-6,7-DIFLUOROQUINAZOLINE

Product Name
4-CHLORO-6,7-DIFLUOROQUINAZOLINE
CAS No.
625080-60-6
Chemical Name
4-CHLORO-6,7-DIFLUOROQUINAZOLINE
Synonyms
Quinazoline, 4-chloro-6,7-difluoro-
CBNumber
CB31502085
Molecular Formula
C8H3ClF2N2
Formula Weight
200.57
MOL File
625080-60-6.mol
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4-CHLORO-6,7-DIFLUOROQUINAZOLINE Property

Boiling point:
290.9±35.0 °C(Predicted)
Density 
1.538±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-0.04±0.70(Predicted)
Appearance
White to light yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
073182
Product name
4-Chloro-6,7-difluoroquinazoline
Purity
95+%
Packaging
500mg
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
073182
Product name
4-Chloro-6,7-difluoroquinazoline
Purity
95+%
Packaging
1g
Price
$218
Updated
2021/12/16
AK Scientific
Product number
W7460
Product name
4-Chloro-6,7-difluoroquinazoline
Packaging
500mg
Price
$252
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0104835
Product name
4-CHLORO-6,7-DIFLUOROQUINAZOLINE
Purity
95.00%
Packaging
1G
Price
$327.6
Updated
2021/12/16
Matrix Scientific
Product number
073182
Product name
4-Chloro-6,7-difluoroquinazoline
Purity
95+%
Packaging
5g
Price
$640
Updated
2021/12/16
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4-CHLORO-6,7-DIFLUOROQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

205259-37-6

625080-60-6

Example 4A Step 2: 6,7-difluoro-4-hydroxyquinazoline (910 mg, 5 mmol) was added to trichlorophos (15 mL) followed by triethylamine (700 μL, 5 mmol). The reaction mixture was heated to reflux at 100 °C for 4 h. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting solid was ground with ethyl acetate (2 × 100 mL), and the combined organic phases were rapidly filtered through a silica gel column to afford 4-chloro-6,7-difluoroquinazoline (870 mg, 4.35 mmol, 87% yield). m/z 201 ([M + H]+) by LC-MS (ESI).

References

[1] Patent: WO2009/117080, 2009, A1. Location in patent: Page/Page column 165
[2] Patent: US2006/281772, 2006, A1. Location in patent: Page/Page column 131

4-CHLORO-6,7-DIFLUOROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-6,7-DIFLUOROQUINAZOLINE Suppliers

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625080-60-6, 4-CHLORO-6,7-DIFLUOROQUINAZOLINERelated Search:

FLUQUINCONAZOLE 4-CHLORO-5,6,7,8-TETRAFLUORO-QUINAZOLINE QUINAZOLINE, 4-CHLORO-6,7-DIFLUORO-2-METHYL- QUINAZOLINE, 4-CHLORO-6,7-DIFLUORO-2-(TRIFLUOROMETHYL)- 2,4-DICHLORO-6,7-DIFLUOROQUINAZOLINE 4-CHLORO-6,7-DIFLUOROQUINAZOLINE

  • Quinazoline, 4-chloro-6,7-difluoro-
  • 625080-60-6
  • CHIRAL CHEMICALS