3,8-Diaza-bicyclo[3.2.1]octane
- Product Name
- 3,8-Diaza-bicyclo[3.2.1]octane
- CAS No.
- 280-06-8
- Chemical Name
- 3,8-Diaza-bicyclo[3.2.1]octane
- Synonyms
- EOS-62178;3,8-Diaza-bicyclo[3.2.1]octane;3,8-Diazabicyclo[3.2.1]octane, 95+%
- CBNumber
- CB31508481
- Molecular Formula
- C6H12N2
- Formula Weight
- 112.17
- MOL File
- 280-06-8.mol
3,8-Diaza-bicyclo[3.2.1]octane Property
- Boiling point:
- 78-80 °C(Press: 40 Torr)
- Density
- 0.975±0.06 g/cm3(Predicted)
- pka
- 10.32±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- CHM0385949
- Product name
- 3,8-DIAZABICYCLO-[3.2.1]-OCTANE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.57
- Updated
- 2021/12/16
- Product number
- 75R0460
- Product name
- 3,8-Diaza-bicyclo[3.2.1]octane
- Purity
- 96%
- Packaging
- 50mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- 75R0460
- Product name
- 3,8-Diaza-bicyclo[3.2.1]octane
- Purity
- 96%
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 75R0460
- Product name
- 3,8-Diaza-bicyclo[3.2.1]octane
- Purity
- 96%
- Packaging
- 250mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- 75R0460
- Product name
- 3,8-Diaza-bicyclo[3.2.1]octane
- Purity
- 96%
- Packaging
- 500mg
- Price
- $199
- Updated
- 2021/12/16
3,8-Diaza-bicyclo[3.2.1]octane Chemical Properties,Usage,Production
Chemical Properties
A colorless fluid boiling 178-180° with piperazine-like smell, which quickly adsorbs carbon dioxide when exposed to air.[2]
Uses
The ring-system of 3,8-Diaza-bicyclo[3.2.1]octane is at once related to piperazine and to nortropine, both progenitors of many compounds of physiological importance, synthesis of 3,8-Diaza-bicyclo[3.2.1]octane seemed likely to be rewarding.[1]
Synthesis
From 3-bentyl-3,8-diazabicyclooctane[3.2.1] (V). A solution of 20 g of 3-benzyl-3,8-diazabicyclooctane [3.2.1] in 400 ml of absolute ethanol
was hydrogenated in the presence of 10 g. of 10% palladium
on charcoal in an autoclave at 60° and 40 atm. pressure.
After 3 hr., heating was stopped and the solution allowed
to cool to room temperature. Then the catalyst was filtered
off, the alcohol removed at atmospheric pressure, and the
concentrated solution was distilled; yield 8.8 g. of 3,8-Diaza-bicyclo[3.2.1]octane (80%) ;
b.p. 176-178'. The product easily adsorbed carbon dioxide
when exposed to air. A sample was distilled again and the
fraction boiling at 78-80°/40 mm. was collected and immediately analyzed.[2]
References
[1] SAMUEL W. BLACKMAN RICHARD B. The Synthesis of 3,8-Diazabicyclo[3.2.1]octane and Some of Its N-Substituted Derivatives[J]. The Journal of Organic Chemistry, 1961, 26 8: 2750-2755. DOI:10.1021/jo01066a032.
[2] GIORGIO CIGNARELLA EMILIO O GIANGIACOMO NATHANSOHN. Bicyclic Homologs of Piperazine. II. Synthesis of 3,8-Diazabicyclo[3.2.1]octane. New Synthesis of 8-Methyl-3,8-diazabicyclo[3.2.1]octane[J]. The Journal of Organic Chemistry, 1961, 26 8: 2747-2750. DOI:10.1021/jo01066a031.
3,8-Diaza-bicyclo[3.2.1]octane Preparation Products And Raw materials
Raw materials
Preparation Products
3,8-Diaza-bicyclo[3.2.1]octane Suppliers
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