8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE

Product Name: 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE
CAS No.: 149771-44-8
Chemical Name: 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE
Synonyms: (1R,5S)-tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate;8-t-butoxycarbonyl-3,8-diazabicyclo[3.2.1]octane;1,1-Dimethylethyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate;EOS-62177;8-BOC-3,8-DIAZA;8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE;1H-Imidazole-4-carboxaldehyde,4-methyl-;149771-44-8;8-Boc-3,8-diaza-bicyclo[3.2.1]octane - [D14360];8-Boc-3,8-diaza-bicyclo[3.2.1]octane hydrochloride
CBNumber: CB5214428
Molecular Formula: C11H20N2O2
Formula Weight: 212.29
MOL File: 149771-44-8.mol

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8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Property

Boiling point:: 295.4±15.0 °C(Predicted)
Density: 1.076±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.53±0.20(Predicted)
form: solid
color: White to off-white
InChI: InChI=1S/C11H20N2O2/c1-11(2,3)15-10(14)13-8-4-5-9(13)7-12-6-8/h8-9,12H,4-7H2,1-3H3
InChIKey: HNINFCBLGHCFOJ-UHFFFAOYSA-N
SMILES: C12N(C(OC(C)(C)C)=O)C(CC1)CNC2

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D6459
Product name: tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate
Purity: min. 98.0 %
Packaging: 1G
Price: $74
Updated: 2025/07/31

TCI Chemical

Product number: D6459
Product name: tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate
Purity: min. 98.0 %
Packaging: 5G
Price: $222
Updated: 2025/07/31

TRC

Product number: T135525
Product name: tert-Butyl3,8-Diazabicyclo[3.2.1]octane-8-carboxylate
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Usbiological

Product number: 263597
Product name: 8-Boc-3,8-diaza-bicyclo[3.2.1]octane
Packaging: 25mg
Price: $355
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB29382
Product name: 8-Boc-3,8-diaza-bicyclo[3.2.1]octane
Packaging: 2g
Price: $560
Updated: 2021/12/16

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8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Chemical Properties,Usage,Production

Uses

tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate is used in preparation of isoquinolinone derivatives and pharmaceutical compounds thereof for prevention or treatment of poly(ADP-ribose)polymerase-1 (PARP-1)-associated diseases.

Synthesis

149771-43-7

149771-44-8

The hydrogenation reaction of tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate (13.0 g, 43.0 mmol) was carried out in ethanol (100 mL, 99%) in the presence of palladium carbon (4.0 g, 5%) catalyst. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was dried and the solvent evaporated to afford the white powdery product tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate. The yield was 8.4 g (92% yield) and the melting point was 103.4-106°C. The product was obtained as follows.

References

[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 5, p. 674 - 681
[2] Patent: US2002/128271, 2002, A1
[3] Patent: EP1213289, 2002, A1. Location in patent: Page 13
[4] Patent: WO2006/106090, 2006, A1. Location in patent: Page/Page column 16
[5] Tetrahedron Letters, 2002, vol. 43, # 5, p. 899 - 902

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Suppliers

Belgium 1 China 228 India 5 Switzerland 1 United Kingdom 4 United States 15 Global 254

Shandong Xuanshuo Pharmaceutical Technology Co. LTD

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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Energy Chemical

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Accela ChemBio Co.,Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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View Lastest Price from 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE 149771-44-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-11-21

Henan Aochuang Chemical Co.,Ltd.

Product: 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE 149771-44-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Honest Joy Holdings Limited

Product: 8-Boc-3,8-diaza-bicyclo[3.2.1]octane 149771-44-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-02-08

149771-44-8, 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANERelated Search:

tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate tert-butyl 6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylate 3-AMINO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-PIPERIDINEACETIC ACID METHYL ESTER tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate tert-Butyl carbazate tert-butyl 3,3a,4,5-tetrahydro-5-oxocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate hydrochloride 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE tert-butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester TERT-BUTYL N-ALLYLCARBAMATE 1-Boc-3-methyl-3-hydroxyp... 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester N-BOC-3-METHYLENE-PIPERIDINE (R)-1-N-Boc-2-methylpiperazine (R)-2-(Aminomethyl)-1-N-Boc-pyyrolidine (S)-1-N-Boc-2-(aminomethyl)pyrrolidine

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE

8-t-butoxycarbonyl-3,8-diazabicyclo[3.2.1]octane

3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 8-BOC protected 97+%

1,1-Dimethylethyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate

EOS-62177

8-Boc-3,8-diaza-bicyclo[3.2.1]octane hydrochloride

3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 1,1-diMethylethyl ester

3,8-Diazabicyclo[3.2.1]octan-8-carboxylic acid tert-butyl ester

8-(tert-Butoxycarbonyl)-3,8-diazabicyclo[3.2.1]octane

tert-butyl (1S,5R)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE ISO 9001：2015 REACH

(1R,5S)-tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate

1H-Imidazole-4-carboxaldehyde,4-methyl-

ert-Butyl3,8-diazabicyclo[3.2.1]octane-8-carboxylate

3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 1,1-dimethylethyl ester (9CI, ACI)

8-BOC-3,8-DIAZA

3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 8-BOC protected

8-Boc-3,8-diaza-bicyclo[3.2.1]octane - [D14360]

tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylatelate

tert-Butyl 3,8-diazabicyclo[3.2.1]octan-8-carboxylate

149771-44-8

pharmaceutical

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