ecallantide
- Product Name
- ecallantide
- CAS No.
- 460738-38-9
- Chemical Name
- ecallantide
- Synonyms
- DX 88;ecallantide;Cys16-Cys40;Cys32-Cys53);ecallantide USP/EP/BP;H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge：Cys7-Cys57
- CBNumber
- CB31508597
- Molecular Formula
- C305H442N88O91S8
- Formula Weight
- 7053.82798
- MOL File
- 460738-38-9.mol
Safety
- Hazardous Substances Data
- 460738-38-9(Hazardous Substances Data)
ecallantide Chemical Properties,Usage,Production
Description
Ecallantide, also known as DX-88, was approved in 2009 in the United States for treatment of hereditary angioedema (HAE), a condition characterized by episodic attacks of localized edema in cutaneous and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1- 1NH). Mutation of the gene that encodes C1-1NH causes the lack or altered activity of the serine protease, C1-1NH. C1-1NH regulates the kallikrein–kinin (contact activation) and complement cascade systems. Ecallantide (DX-88) was designed to inhibit the action of plasma kallikrein. Ecallantide is a potent and selective inhibitor of plasma kallikrein with a Ki= 25 pM. The discovery program that identified ecallantide used phage display technology and a library of designed variants of the first Kunitz domain of TFPI. Ecallantide, a 60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by 7-amino acids. Ecallantide has been developed as a subcutaneous administered formulation.
Originator
Dyax Corp. (United States)
Uses
Treatment of hereditary angioedema; reduction of blood loss during cardiothoracic surgery (plasma kallikrein inhibitor).
brand name
Kalbitor
ecallantide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ecallantide manufacturers
- Product
- Ecallantide 460738-38-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1000g
- Release date
- 2023-01-12
- Product
- ecallantide 460738-38-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2023-11-15