Omtriptolide

Product Name: Omtriptolide
CAS No.: 195883-06-8
Chemical Name: Omtriptolide
Synonyms: OMTRIPTOLIDE;Unii-D36elm729p;Butanedioic acid, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, 1-[(3bS,4aS,5aR,6R,6aS,7aS,7bS,8aS,8bS)-1,3,3b,4,4a,6,6a,7a,7b,8b,9,10-dodecahydro-8b-methyl-6a-(1-methylethyl)-1-oxotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-6-yl] ester
CBNumber: CB31509125
Molecular Formula: C24H28O9
Formula Weight: 460.47
MOL File: 195883-06-8.mol

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Omtriptolide Property

Melting point:: 109-111 ºC
Boiling point:: 691.4±55.0 °C(Predicted)
Density: 1.49
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 4.36±0.17(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6982
Product name: Omtriptolide
Purity: 98.23%
Packaging: 1mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-6982
Product name: Omtriptolide
Purity: 98.23%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009669
Product name: OMTRIPTOLIDE
Purity: 95.00%
Packaging: 5MG
Price: $504.86
Updated: 2021/12/16

ChemScene

Product number: CS-6982
Product name: Omtriptolide
Purity: 98.23%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-6982
Product name: Omtriptolide
Purity: 98.23%
Packaging: 25mg
Price: $1300
Updated: 2021/12/16

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Omtriptolide Chemical Properties,Usage,Production

Uses

Antineoplastic.

in vivo

In a mouse model of cisplatin-induced AKI, omtriptolide results in a significant decrease in blood urea nitrogen (BUN), serum creatinine, and acute tubular necrosis (ATN) score, and a nonsignificant increase in tubular apoptosis score in AKI. The protection of omtriptolide against AKI is associated with a decrease in p-ERK and is independent of MKP-1 and proinflammatory cytokines^[1]. In a mouse heterotopic tracheal allograft model of obliterative airway disease, omtriptolide attenuates airway obliteration and inhibits accumulation of inflammatory cells, and therefore may have preventive or therapeutic benefits for patients with obliterative airway disease following lung transplantation^[2]. Omtriptolide inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. Omtriptolide also markedly reduces the number of myofibroblasts in the bleomycin treatment group^[3]. Omtriptolide inhibits in vivo both CD4+Vbeta3+ and CD8+Vbeta3+ T cell (alloreactive T cells in this model) expansion in the spleen by 64.09 and 34.02%, respectively, at the time when Vbeta3+ cell expansion is in the logarithmic phase (day 3 after transplantation)^[4].

IC 50

ERK

Omtriptolide Preparation Products And Raw materials

Raw materials

Preparation Products

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Omtriptolide Suppliers

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195883-06-8, OmtriptolideRelated Search:

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OMTRIPTOLIDE

Unii-D36elm729p

Butanedioic acid, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, 1-[(3bS,4aS,5aR,6R,6aS,7aS,7bS,8aS,8bS)-1,3,3b,4,4a,6,6a,7a,7b,8b,9,10-dodecahydro-8b-methyl-6a-(1-methylethyl)-1-oxotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-6-yl] ester

195883-06-8