ChemicalBook > CAS DataBase List > 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE

2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE

Product Name
2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE
CAS No.
1218-69-5
Chemical Name
2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE
Synonyms
division;Deferasirox Intermediate;Deferasirox EP Impurity B;Deferasirox Benzoxazin IMpurity;2-(o-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one;2-(2-Hydroxyphenyl)benz[e][1,3]oxazin-4-one;2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE;2-(2-Hydroxyphenyl)-4H-1,3-benzoxazine-4-one;4H-1,3-Benzoxazin-4-one, 2-(2-hydroxyphenyl)-;2-(2-Hydroxy-phenyl)-benzo[e][1,3]oxazin-4-one
CBNumber
CB31511748
Molecular Formula
C14H9NO3
Formula Weight
239.23
MOL File
1218-69-5.mol
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2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE Property

Melting point:
204.0 to 208.0 °C
Boiling point:
425.0±47.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Very Slightly, Heated)
form 
Solid
pka
8.07±0.35(Predicted)
color 
Pale Yellow to Light Yellow
λmax
371nm(H2O)(lit.)
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1653
Product name
2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Purity
>98.0%(GC)
Packaging
1g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
H1653
Product name
2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Purity
>98.0%(GC)
Packaging
5g
Price
$125
Updated
2025/07/31
TRC
Product number
H951240
Product name
2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Packaging
250mg
Price
$175
Updated
2021/12/16
TRC
Product number
H951240
Product name
2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Packaging
1g
Price
$510
Updated
2021/12/16
Matrix Scientific
Product number
112059
Product name
2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Purity
>95%
Packaging
5g
Price
$98
Updated
2021/12/16
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2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Intermediate in the production of Deferasirox.

Synthesis

1972-71-0

1218-69-5

General procedure for the synthesis of 2-(2-hydroxyphenyl)-4H-benzo[E][1,3]oxazin-4-one from 2-hydroxy-N-(2-hydroxybenzoyl)benzamide: Toluene (1,400 mL) and 10.5 g of p-toluenesulfonic acid monohydrate were added to 140 g of the synthesis intermediate mA, and the reaction mixture was stirred and reacted for 6 hours at 150 °C. Upon completion of the reaction, the mixture was cooled to 60 °C, followed by the addition of 14 mL of triethylamine to the reaction solution and continued cooling to room temperature. The resulting solid was collected by filtration and washed with distilled water to yield 122 g of the synthesized intermediate mB in 94% yield.

References

[1] Patent: EP2460799, 2012, A1. Location in patent: Page/Page column 40-41

2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE 1218-69-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-18
Career Henan Chemical Co
Product
2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE 1218-69-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

1218-69-5, 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONERelated Search:

Deferasirox Ethyl Ester Deferasirox Impurity 13 13,14-(1,3-Butadiene-1,4-diyl)-[9,10-(1,3-butadiene-1,4-diyl)-[5,6-(1,3-butadiene-1,4-diyl)-[1,2-(1,3-butadiene-1,4-diyl)-4,8,12,16-tetraoxacyclohexadecane-1,5,9,13-tetraene-3,7,11,15-tetraone]]] Disalicylimide 5-Methoxycarbonyl Deferasirox Deferasirox Impurity 8 Deferasirox Deferasirox Salicyloyl Ester Deferasirox Methyl Ester 4-Hydrazinylbenzoic acid Deferasirox Impurity 14 Deferasirox Ferrate(III) TripotassiuM CoMplex Methanoate Hydrate BetaMethasone Enol Aldehyde E IsoMer CGP-72670-d4 Deferasirox Acyl-β-D-glucuronide

  • 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE
  • 2-(2-Hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one
  • 2-(2-Hydroxyphenyl)benz[e][1,3]oxazin-4-one
  • 2-(o-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
  • 2-(2-Hydroxy-phenyl)-benzo[e][1,3]oxazin-4-one
  • Deferasirox Benzoxazin IMpurity
  • Deferasirox Intermediate
  • 4H-1,3-Benzoxazin-4-one, 2-(2-hydroxyphenyl)-
  • Deferasirox EP Impurity B
  • division
  • 2-(2-Hydroxypehnyl)-4H-benzo[e][1,3]oxazin-4-one
  • 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazine-4-one
  • 1218-69-5
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • john's