2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE

Product Name: 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE
CAS No.: 1218-69-5
Chemical Name: 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE
Synonyms: division;Deferasirox Intermediate;Deferasirox EP Impurity B;Deferasirox Benzoxazin IMpurity;2-(o-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one;2-(2-Hydroxyphenyl)benz[e][1,3]oxazin-4-one;2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE;2-(2-Hydroxyphenyl)-4H-1,3-benzoxazine-4-one;4H-1,3-Benzoxazin-4-one, 2-(2-hydroxyphenyl)-;2-(2-Hydroxy-phenyl)-benzo[e][1,3]oxazin-4-one
CBNumber: CB31511748
Molecular Formula: C14H9NO3
Formula Weight: 239.23
MOL File: 1218-69-5.mol

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2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE Property

Melting point:: 204.0 to 208.0 °C
Boiling point:: 425.0±47.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Very Slightly, Heated)
form: Solid
pka: 8.07±0.35(Predicted)
color: Pale Yellow to Light Yellow
λmax: 371nm(H2O)(lit.)

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1653
Product name: 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Purity: >98.0%(GC)
Packaging: 1g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: H1653
Product name: 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Purity: >98.0%(GC)
Packaging: 5g
Price: $125
Updated: 2025/07/31

TRC

Product number: H951240
Product name: 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Packaging: 250mg
Price: $175
Updated: 2021/12/16

TRC

Product number: H951240
Product name: 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Packaging: 1g
Price: $510
Updated: 2021/12/16

Matrix Scientific

Product number: 112059
Product name: 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one
Purity: >95%
Packaging: 5g
Price: $98
Updated: 2021/12/16

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2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Intermediate in the production of Deferasirox.

Synthesis

1972-71-0

1218-69-5

General procedure for the synthesis of 2-(2-hydroxyphenyl)-4H-benzo[E][1,3]oxazin-4-one from 2-hydroxy-N-(2-hydroxybenzoyl)benzamide: Toluene (1,400 mL) and 10.5 g of p-toluenesulfonic acid monohydrate were added to 140 g of the synthesis intermediate mA, and the reaction mixture was stirred and reacted for 6 hours at 150 °C. Upon completion of the reaction, the mixture was cooled to 60 °C, followed by the addition of 14 mL of triethylamine to the reaction solution and continued cooling to room temperature. The resulting solid was collected by filtration and washed with distilled water to yield 122 g of the synthesized intermediate mB in 94% yield.

References

[1] Patent: EP2460799, 2012, A1. Location in patent: Page/Page column 40-41

2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE Suppliers

Americas 1 Canada 2 China 141 Europe 1 India 29 Japan 1 United States 8 Global 183

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View Lastest Price from 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE 1218-69-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000KGS
Release date: 2025-02-18

Career Henan Chemical Co

Product: 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE 1218-69-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

1218-69-5, 2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONERelated Search:

Deferasirox Ethyl Ester Deferasirox Impurity 13 13,14-(1,3-Butadiene-1,4-diyl)-[9,10-(1,3-butadiene-1,4-diyl)-[5,6-(1,3-butadiene-1,4-diyl)-[1,2-(1,3-butadiene-1,4-diyl)-4,8,12,16-tetraoxacyclohexadecane-1,5,9,13-tetraene-3,7,11,15-tetraone]]] Disalicylimide 5-Methoxycarbonyl Deferasirox Deferasirox Impurity 8 Deferasirox Deferasirox Salicyloyl Ester Deferasirox Methyl Ester 4-Hydrazinylbenzoic acid Deferasirox Impurity 14 Deferasirox Ferrate(III) TripotassiuM CoMplex Methanoate Hydrate BetaMethasone Enol Aldehyde E IsoMer CGP-72670-d4 Deferasirox Acyl-β-D-glucuronide

2-(2-HYDROXYPHENYL)-4H-1,3-BENZOXAZIN-4-ONE

2-(2-Hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one

2-(2-Hydroxyphenyl)benz[e][1,3]oxazin-4-one

2-(o-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one

2-(2-Hydroxy-phenyl)-benzo[e][1,3]oxazin-4-one

Deferasirox Benzoxazin IMpurity

Deferasirox Intermediate

4H-1,3-Benzoxazin-4-one, 2-(2-hydroxyphenyl)-

Deferasirox EP Impurity B

division

2-(2-Hydroxypehnyl)-4H-benzo[e][1,3]oxazin-4-one

2-(2-Hydroxyphenyl)-4H-1,3-benzoxazine-4-one

1218-69-5

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