2-Bromo-5-formyl-3-methylpyridine
- Product Name
- 2-Bromo-5-formyl-3-methylpyridine
- CAS No.
- 885167-81-7
- Chemical Name
- 2-Bromo-5-formyl-3-methylpyridine
- Synonyms
- KML-12;CML-014;6-bromo-5-methylnicotinaldehyde;2-Bromo-5-formyl-3-methylpyridine;6-BroMo-5-Methyl-pyridine-3-carbaldehyde;6-Bromo-5-methyl-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 6-bromo-5-methyl-
- CBNumber
- CB31512482
- Molecular Formula
- C7H6BrNO
- Formula Weight
- 200.03
- MOL File
- 885167-81-7.mol
2-Bromo-5-formyl-3-methylpyridine Property
- Boiling point:
- 300.2±42.0 °C(Predicted)
- Density
- 1.577±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.72±0.20(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B613635
- Product name
- 6-Bromo-5-methylnicotinaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 174579
- Product name
- 6-Bromo-5-methylnicotinaldehyde
- Packaging
- 10g
- Price
- $1764
- Updated
- 2021/12/16
- Product number
- Z0993
- Product name
- 2-Bromo-5-formyl-3-methylpyridine
- Packaging
- 1g
- Price
- $482
- Updated
- 2021/12/16
- Product number
- HCH0355435
- Product name
- 6-BROMO-5-METHYLNICOTINALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.22
- Updated
- 2021/12/16
- Product number
- 174579
- Product name
- 6-Bromo-5-methylnicotinaldehyde
- Packaging
- 1g
- Price
- $540
- Updated
- 2021/12/16
2-Bromo-5-formyl-3-methylpyridine Chemical Properties,Usage,Production
Synthesis
4394-85-8
3430-18-0
885167-81-7
The general procedure for the synthesis of 2-bromo-3-methyl-5-formylpyridine from N-formylmorpholine and 2,5-dibromo-3-methylpyridine is as follows: Method 4: Preparation of 6-bromo-5-methylnicotinaldehyde 1. A solution of 2,5-dibromo-3-methylpyridine (5.1 g, 20.30 mmol) in tetrahydrofuran (25 ml) was slowly added dropwise to a solution of 2M isopropylmagnesium chloride (10.7 ml, 21.3 mmol) in tetrahydrofuran which had been pre-cooled to 0 °C at 0 °C. 2. The reaction mixture was stirred at 0°C for 2 hours, followed by continued stirring at room temperature for 1 hour. 3. a solution of tetrahydrofuran (25 ml) of 4-formylmorpholine (2.1 ml, 20.3 mmol) was slowly added dropwise to the reaction mixture, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. 4. The reaction mixture was poured into water and the aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. 5. The residue was purified by fast column chromatography to afford the target product 2-bromo-3-methyl-5-formylpyridine (3.0 g, 74% yield) using isohexane solution of 10% ethyl acetate as eluent. NMR spectrum (DMSO-d6): δ 2.44 (s, 3H), 8.19 (s, 1H), 8.73 (s, 1H), 10.09 (s, 1H).
References
[1] Patent: US2008/119451, 2008, A1. Location in patent: Page/Page column 35
[2] Patent: WO2007/71956, 2007, A1. Location in patent: Page/Page column description
[3] Patent: US2012/184520, 2012, A1. Location in patent: Page/Page column 24
2-Bromo-5-formyl-3-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-formyl-3-methylpyridine manufacturers
- Product
- 2-Bromo-5-formyl-3-methylpyridine 885167-81-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12