2-Bromopyridine-5-carbaldehyde
- Product Name
- 2-Bromopyridine-5-carbaldehyde
- CAS No.
- 149806-06-4
- Chemical Name
- 2-Bromopyridine-5-carbaldehyde
- Synonyms
- 6-BROMONICOTINALDEHYDE;2-BROMO-5-FORMYLPYRIDINE;6-BROMO-PYRIDINE-3-CARBALDEHYDE;6-BROMO-3-PYRIDINECARBOXALDEHYDE;6-BROMOPYRIDINE-3-CARBOXALDEHYDE;2-Bromo-5-aldopyridine;Abemaciclib Impurity 37;6-Bromo-3-pyridinecarboxaL;2-BROMO-5-FORMYLPYRIDINE97+%;2-BroMopridine-5-carbaldehyde
- CBNumber
- CB5396137
- Molecular Formula
- C6H4BrNO
- Formula Weight
- 186.01
- MOL File
- 149806-06-4.mol
2-Bromopyridine-5-carbaldehyde Property
- Melting point:
- 104-110 °C(lit.)
- Boiling point:
- 284°
- Density
- 1.683
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in dichloromethane, ether, ethyl acetate and methanol.
- form
- Solid
- pka
- -1.01±0.10(Predicted)
- color
- Pale yellow
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C6H4BrNO/c7-6-2-1-5(4-9)3-8-6/h1-4H
- InChIKey
- PVUKGNBRJFTFNJ-UHFFFAOYSA-N
- SMILES
- C1=NC(Br)=CC=C1C=O
- CAS DataBase Reference
- 149806-06-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 596280
- Product name
- 6-Bromo-3-pyridinecarboxaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $14.9
- Updated
- 2025/07/31
- Product number
- 596280
- Product name
- 6-Bromo-3-pyridinecarboxaldehyde
- Purity
- 95%
- Packaging
- 5g
- Price
- $92.4
- Updated
- 2025/07/31
- Product number
- B3491
- Product name
- 6-Bromo-3-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- B3491
- Product name
- 6-Bromo-3-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $87
- Updated
- 2025/07/31
- Product number
- 596280
- Product name
- 6-Bromo-3-pyridinecarboxaldehyde
- Purity
- 95%
- Packaging
- 25g
- Price
- $349
- Updated
- 2025/07/31
2-Bromopyridine-5-carbaldehyde Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
A useful synthetic intermediate. 6-Bromonicotinaldehyde is used in wittig reaction. Hydrodehalogenation of 6-bromonicotinaldehyde to produce alcohol.
Uses
2-Bromopyridine-5-carbaldehyde can be a useful synthetic intermediate
Synthesis
154321-32-1
149806-06-4
General procedure for the synthesis of 2-bromo-5-formylpyridine (Intermediate 1b) from 2-bromo-5-(dibromomethyl)pyridine (Intermediate Ia, 3.650 g, 11.07 mmol): a mixture of Intermediate Ia with calcium carbonate (2.437 g, 24.35 mmol) in water (80 ml) was stirred and reacted for 16 hours at 105 °C. After completion of the reaction, the mixture was cooled to room temperature, diluted with water and extracted twice with ethyl acetate (EtOAc). The organic phases were combined, washed sequentially with water and saturated sodium chloride (NaCl) solution, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give Intermediate 1b (1.890 g, 92% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 10.05 (s, 1H), 8.78 (d, J = 2.2 Hz, 1H), 7.98 (dd, J = 8.2,2.4 Hz, 1H), 7.65 (d, J = 8.2 Hz, 1H).
References
[1] Patent: WO2016/124747, 2016, A1. Location in patent: Page/Page column 58; 59
[2] Patent: US2018/202388, 2018, A1
[3] Tetrahedron Letters, 2005, vol. 46, # 36, p. 6033 - 6036
[4] Synthesis, 1994, # 1, p. 87 - 92
2-Bromopyridine-5-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromopyridine-5-carbaldehyde Suppliers
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View Lastest Price from 2-Bromopyridine-5-carbaldehyde manufacturers
- Product
- 6-Bromonicotinaldehyde 149806-06-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-26
- Product
- Abemaciclib Impurity 37 149806-06-4
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 10000
- Release date
- 2025-03-05
- Product
- 2-Bromopyridine-5-Carbaldehyde 149806-06-4
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-14