CA-074 ME
- Product Name
- CA-074 ME
- CAS No.
- 147859-80-1
- Chemical Name
- CA-074 ME
- Synonyms
- CA-074 ME;CA-074(OME);CA-074 methyl ester;CATHEPSIN B INHIBITOR IV;CA-074Me/CA-074 methyl ester;CA-074 methyl ester (CA-074 Me);L-trans-Epoxysuccinyl(propylamide)-Ile-P;(L-3-Trans-(propylcarbamoyl)oxirane-2-carbony;L-TRANS-EPOXYSUCCINYL-ILE-PRO-OME PROPYLAMIDE;L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OME
- CBNumber
- CB3152175
- Molecular Formula
- C19H31N3O6
- Formula Weight
- 397.47
- MOL File
- 147859-80-1.mol
CA-074 ME Property
- Melting point:
- 153-155°C
- Boiling point:
- 666.3±55.0 °C(Predicted)
- Density
- 1.212±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- pka
- 13.38±0.40(Predicted)
- form
- Solid
- color
- White to Off-White
- InChIKey
- XGWSRLSPWIEMLQ-YTFOTSKYSA-N
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C5857
- Product name
- CA-074 methyl ester
- Purity
- ≥99% (TLC)
- Packaging
- 5mg
- Price
- $440
- Updated
- 2024/03/01
- Product number
- 205531
- Product name
- CA-074 Me
- Purity
- CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
- Packaging
- 1MG
- Price
- $272
- Updated
- 2024/03/01
- Product number
- J64737
- Product name
- Cathepsin B Inhibitor IV
- Packaging
- 10mg
- Price
- $602
- Updated
- 2023/06/20
- Product number
- 18469
- Product name
- CA-074 methyl ester
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 18469
- Product name
- CA-074 methyl ester
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $109
- Updated
- 2024/03/01
CA-074 ME Chemical Properties,Usage,Production
Uses
CA-074 methyl ester is a cell-permeable cathepsin B inhibitor.
Uses
CA-074 methyl ester has been used as cathepsin B inhibitor in cardiomyocytes, HeLa cells and human pancreatic cancer PANC-1 cells.
Biological Activity
ca-074 me is a membrane-permeable and selective inhibitor of cathepsin b with ic50 value of 36.3 nm [1, 2].ca-074 me is a methyl ester derivative of ca-074. in cultured human gingival fibroblasts, ca-074 me exerted a 95% inhibition of cathepsin b and partial inhibition (54%) of the combined activities of cathepsins b and l. ca-074 me was also found to inhibit cathespin l under reducing conditions. it inhibited the activity of purified human cathepsin l by more than 90% when the enzyme had been pre-incubated with 1.4 mm dtt or 4.2 mm gsh for 2 hours. besides that, ca-074 me completely inhibited cathepsin b in the presence of 1.4 mm dtt [2, 3].
Biochem/physiol Actions
CA-074 methyl ester is a cell-permeable analog of CA-074. It is an inhibitor of cathepsin B especially the intracellular type. and undergoes intracellular transition into active CA-074 by the action of esterases. CA-074 methyl ester also inhibits cathepsin L.
target
cathepsin B
References
[1] wu x, zhang l, gurley e, et al. prevention of free fatty acid–induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways. hepatology, 2008, 47(6): 1905-1915.
[2] steverding d. the cathepsin b-selective inhibitors ca-074 and ca-074me inactivate cathepsin l under reducing conditions. open enzyme inhibition journal, 2011, 4: 11-16.
[3] buttle d j, murata m, knight c g, et al. ca074 methyl ester: a proinhibitor for intracellular cathepsin b. archives of biochemistry and biophysics, 1992, 299(2): 377-380.
CA-074 ME Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CA-074 ME manufacturers
- Product
- CA-074 ME 147859-80-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23