ChemicalBook > CAS DataBase List > CA-074 ME

CA-074 ME

Product Name
CA-074 ME
CAS No.
147859-80-1
Chemical Name
CA-074 ME
Synonyms
CA-074 ME;CA-074(OME);CA-074 methyl ester;CATHEPSIN B INHIBITOR IV;CA-074Me/CA-074 methyl ester;CA-074 methyl ester (CA-074 Me);L-trans-Epoxysuccinyl(propylamide)-Ile-P;(L-3-Trans-(propylcarbamoyl)oxirane-2-carbony;L-TRANS-EPOXYSUCCINYL-ILE-PRO-OME PROPYLAMIDE;L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OME
CBNumber
CB3152175
Molecular Formula
C19H31N3O6
Formula Weight
397.47
MOL File
147859-80-1.mol
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CA-074 ME Property

Melting point:
153-155°C
Boiling point:
666.3±55.0 °C(Predicted)
Density 
1.212±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO
pka
13.38±0.40(Predicted)
form 
Solid
color 
White to Off-White
InChIKey
XGWSRLSPWIEMLQ-YTFOTSKYSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C5857
Product name
CA-074 methyl ester
Purity
≥99% (TLC)
Packaging
5mg
Price
$440
Updated
2024/03/01
Sigma-Aldrich
Product number
205531
Product name
CA-074 Me
Purity
CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
Packaging
1MG
Price
$272
Updated
2024/03/01
Alfa Aesar
Product number
J64737
Product name
Cathepsin B Inhibitor IV
Packaging
10mg
Price
$602
Updated
2023/06/20
Cayman Chemical
Product number
18469
Product name
CA-074 methyl ester
Purity
≥98%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
18469
Product name
CA-074 methyl ester
Purity
≥98%
Packaging
1mg
Price
$109
Updated
2024/03/01
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CA-074 ME Chemical Properties,Usage,Production

Uses

CA-074 methyl ester is a cell-permeable cathepsin B inhibitor.

Uses

CA-074 methyl ester has been used as cathepsin B inhibitor in cardiomyocytes, HeLa cells and human pancreatic cancer PANC-1 cells.

Biological Activity

ca-074 me is a membrane-permeable and selective inhibitor of cathepsin b with ic50 value of 36.3 nm [1, 2].ca-074 me is a methyl ester derivative of ca-074. in cultured human gingival fibroblasts, ca-074 me exerted a 95% inhibition of cathepsin b and partial inhibition (54%) of the combined activities of cathepsins b and l. ca-074 me was also found to inhibit cathespin l under reducing conditions. it inhibited the activity of purified human cathepsin l by more than 90% when the enzyme had been pre-incubated with 1.4 mm dtt or 4.2 mm gsh for 2 hours. besides that, ca-074 me completely inhibited cathepsin b in the presence of 1.4 mm dtt [2, 3].

Biochem/physiol Actions

CA-074 methyl ester is a cell-permeable analog of CA-074. It is an inhibitor of cathepsin B especially the intracellular type. and undergoes intracellular transition into active CA-074 by the action of esterases. CA-074 methyl ester also inhibits cathepsin L.

target

cathepsin B

References

[1] wu x, zhang l, gurley e, et al. prevention of free fatty acid–induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways. hepatology, 2008, 47(6): 1905-1915.
[2] steverding d. the cathepsin b-selective inhibitors ca-074 and ca-074me inactivate cathepsin l under reducing conditions. open enzyme inhibition journal, 2011, 4: 11-16.
[3] buttle d j, murata m, knight c g, et al. ca074 methyl ester: a proinhibitor for intracellular cathepsin b. archives of biochemistry and biophysics, 1992, 299(2): 377-380.

CA-074 ME Preparation Products And Raw materials

Raw materials

Preparation Products

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CA-074 ME Suppliers

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View Lastest Price from CA-074 ME manufacturers

Career Henan Chemical Co
Product
CA-074 ME 147859-80-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-23

147859-80-1, CA-074 MERelated Search:

Succinic acid N-ACETYLLACTOSAMINE Disodium succinate 5 MG CA-074INHIBITOR FOR CATHEPSIN B 5 MG CA-074 ME, PROINH. FOR INTRACELLULARCATHEPSIN B MEMBRANE-PERMEABLE ANALOG OF CA-074 CA-074 METHYL ESTER METHYL 1-ETHYLPYRROLIDINE-2-CARBOXYLATE H-VAL-PRO-OH HCL AC-PRO-OME CA-074 CA-074 ME

  • N-(L-3-TRANS-PROPYLCARBONYL-OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE METHYL ESTER
  • L-trans-Epoxysuccinyl(propylamide)-Ile-P
  • (L-3-Trans-(propylcarbamoyl)oxirane-2-carbony
  • L-trans-Epoxysuccinic Ile-Pro-OMe Propylamide
  • L-trans-Epoxysuccinyl-isoleucyl-proline methyl ester propylamide
  • CA-074 methyl ester
  • (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester
  • CA-074(OME)
  • (S)-Methyl 1-((2S,3S)-3-methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)p
  • L-TRANS-EPOXYSUCCINYL-ILE-PRO-OME PROPYLAMIDE
  • L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OME
  • CA-074 ME
  • CATHEPSIN B INHIBITOR IV
  • [L-3-TRANS-(POLYCARBAMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE METHYL ESTER
  • (L-3-TRANS-(PROPYLCARBAMOYL)OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE METHYL ESTER
  • [L-3-TRANS-(PROPYLCARBAMOYL)OXYRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE METHYL ESTER
  • N-((L-3-TRANS-(PROPYLAMINO)CARBONYL)-OXIRANE-2-CARBONYL)-ILE-PRO-OME
  • L-trans-Epoxysuccinyl(propylaMide)-Ile-Pro-OMe, CA-074Me, N-(L-3-trans-(PropylaMino)carbonyl)-oxirane-2-carbonyl)-Ile-Pro-OMe
  • (S)-Methyl 1-((2S,3S)-3-methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylate
  • CA-074 methyl ester (CA-074 Me)
  • L-Proline, N-[[(2S,3S)-3-[(propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-, methyl ester
  • CA-074Me/CA-074 methyl ester
  • Methyl ((2S,3S)-3-(propylcarbamoyl)oxirane-2-carbonyl)-L-isoleucyl-L-prolinate
  • 147859-80-1
  • peptides
  • Pepetides