1-(aminomethyl)cyclopentanol hydrochloride
- Product Name
- 1-(aminomethyl)cyclopentanol hydrochloride
- CAS No.
- 76066-27-8
- Chemical Name
- 1-(aminomethyl)cyclopentanol hydrochloride
- Synonyms
- cyclopentanol hydrochloride;1-(Aminomethyl)cyclopentanol, HCl;1-(aminomethyl)cyclopentanol hydrochloride;1-(aminomethyl)cyclopentan-1-ol hydrochloride;Cyclopentanol, 1-(aMinoMethyl)-, hydrochloride
- CBNumber
- CB31541611
- Molecular Formula
- C6H14ClNO
- Formula Weight
- 151.63446
- MOL File
- 76066-27-8.mol
1-(aminomethyl)cyclopentanol hydrochloride Property
- Melting point:
- 190℃
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2922190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A633445
- Product name
- 1-(Aminomethyl)cyclopentanolHydrochloride
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W003998
- Product name
- 1-(Aminomethyl)cyclopentanolhydrochloride
- Packaging
- 250mg
- Price
- $52
- Updated
- 2021/12/16
- Product number
- FA140144
- Product name
- 1-(Aminomethyl)cyclopentanol hydrochloride
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-W003998
- Product name
- 1-(Aminomethyl)cyclopentanolhydrochloride
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- FA140144
- Product name
- 1-(Aminomethyl)cyclopentanol hydrochloride
- Packaging
- 2g
- Price
- $162
- Updated
- 2021/12/16
1-(aminomethyl)cyclopentanol hydrochloride Chemical Properties,Usage,Production
Uses
1-(Aminomethyl)cyclopentanol Hydrochloride is used for preparation and inhibition of phenylethanolamine N-methyltransferase. It is also used for preparation of sulfonyl benzimidazole derivatives useful in treatment of diseases-mediated by CB2 receptor.
Synthesis
5117-85-1
76066-27-8
The general procedure for the synthesis of 1-(aminomethyl)cyclopentanol hydrochloride from 1-hydroxycyclopentanecarbonitrile was as follows: to a mixture of cyclopentanone (5.50 g, 65.0 mmol) and ZnBr2 (0.20 g, 8.00 mmol) under cooling in an ice bath, TMSCN (10.0 mL, 73.4 mmol) was slowly added, and the reaction was subsequently stirred at room temperature for mixture for 12 hours. The resulting cyanohydrin solution was slowly added dropwise to a suspension of LiAlH4 (8.34 g, 219 mmol) in THF (30.0 mL) at 0 °C, and the mixture was then heated to reflux for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and water (10.0 mL), 4M NaOH aqueous solution (10.0 mL), and water (10.0 mL) were added slowly and sequentially under vigorous stirring. Insoluble material was removed by filtration through a diatomaceous earth pad, and the organic phase was separated and dried with KOH. The dried organic phase was decanted, dried over Na2SO4, filtered and concentrated. The residue was dissolved in MTBE (100 mL), a dioxane solution (10.0 mL) of 4N HCl was added, and stirred at room temperature for 30 minutes. The resulting white solid precipitate was collected by filtration through a sintered funnel to afford the target product 1-(aminomethyl)cyclopentanol hydrochloride (6.68 g, 68% yield).
References
[1] Patent: US2017/217986, 2017, A1. Location in patent: Paragraph 0564; 0565
1-(aminomethyl)cyclopentanol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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