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2-(2-bromo-4-fluorophenyl)pyrrolidine

Product Name
2-(2-bromo-4-fluorophenyl)pyrrolidine
CAS No.
1016499-98-1
Chemical Name
2-(2-bromo-4-fluorophenyl)pyrrolidine
Synonyms
2-(2-bromo-4-fluorophenyl)pyrrolidine;Pyrrolidine, 2-(2-bromo-4-fluorophenyl)-
CBNumber
CB31556806
Molecular Formula
C10H11BrFN
Formula Weight
244.1
MOL File
1016499-98-1.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0050374
Product name
2-(2-BROMO-4-FLUOROPHENYL)PYRROLIDINE
Purity
95.00%
Packaging
5MG
Price
$505.52
Updated
2021/12/16
Labseeker
Product number
SC-35619
Product name
2-(2-bromo-4-fluorophenyl)pyrrolidine
Purity
95
Packaging
5g
Price
$1633
Updated
2021/12/16
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2-(2-bromo-4-fluorophenyl)pyrrolidine Chemical Properties,Usage,Production

Reactions

2-(2-bromo-4-fluorophenyl)pyrrolidine is an important intermediate for the synthesis of various organic compounds. This organic compound can be used to react with Pyrazolo(1,5a)pyrimidine to synthesize 4-fluoro-2-bromo-Larotrectinib, a radioactive iodine-marked Larotrectinib compound.

Synthesis

The oily 5-(2-bromo-4-fluorobenzene)-3,4-dihydro-2H-pyrrole (6.05g, 0.025mmoL) was dissolved in 100mL of methanol and water (4:1) solution, cooled to 0 degree,Sodium borohydride (0.95 mg, 0.025 mmol) was added in portions with hydrogen evolution.The reaction solution became a yellow turbid liquid, and after 3 hours, it was allowed to warm to room temperature, and the solvent was distilled off.The residue was treated with KHCO3 and extracted with ethyl acetate.The organic layer was dried over anhydrous sodium sulfate and filtered and evaporated. A pale yellow oil was obtained, and 5.84 g of 2-(2-bromo-4-fluorophenyl)pyrrolidine crude product was obtained, with a yield of 95.7%, which was directly reacted.

2-(2-bromo-4-fluorophenyl)pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-bromo-4-fluorophenyl)pyrrolidine Suppliers

China 7 Ukraine 1 United States 1 Global 9
UkrOrgSynthesis Ltd.
Tel
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Fax
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Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
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1016499-98-1, 2-(2-bromo-4-fluorophenyl)pyrrolidineRelated Search:

(S)-2-(4-Fluorophenyl)pyrrolidine 2-(2-Bromophenyl)pyrrolidine 2-(3,5-Dichlorophenyl)Pyrrolidine 2-(3-Chloro-phenyl)-pyrrolidine (R)-2-(2-Chlorophenyl)pyrrolidine

  • 2-(2-bromo-4-fluorophenyl)pyrrolidine
  • Pyrrolidine, 2-(2-bromo-4-fluorophenyl)-
  • 1016499-98-1