2-chloro-5,6,7,8-tetrahydroquinoline
- Product Name
- 2-chloro-5,6,7,8-tetrahydroquinoline
- CAS No.
- 21172-88-3
- Chemical Name
- 2-chloro-5,6,7,8-tetrahydroquinoline
- Synonyms
- 2-chloro-5,6,7,8-tetrahydroquinoline;Quinoline, 2-chloro-5,6,7,8-tetrahydro-
- CBNumber
- CB31557823
- Molecular Formula
- C9H10ClN
- Formula Weight
- 167.64
- MOL File
- 21172-88-3.mol
2-chloro-5,6,7,8-tetrahydroquinoline Property
- Melting point:
- 93-95 °C
- Boiling point:
- 260℃
- Density
- 1.185
- Flash point:
- 136℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.46±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C9H10ClN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h5-6H,1-4H2
- InChIKey
- ZUXMRCHYHAWERW-UHFFFAOYSA-N
- SMILES
- N1C2=C(CCCC2)C=CC=1Cl
Safety
- HS Code
- 2933499090
N-Bromosuccinimide Price
- Product number
- C433328
- Product name
- 2-Chloro-5,6,7,8-tetrahydroquinoline
- Packaging
- 20mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC141269
- Product name
- 2-Chloro-5,6,7,8-tetrahydroquinoline
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC141269
- Product name
- 2-Chloro-5,6,7,8-tetrahydroquinoline
- Packaging
- 250mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FC141269
- Product name
- 2-Chloro-5,6,7,8-tetrahydroquinoline
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Z4404
- Product name
- 2-Chloro-5,6,7,8-tetrahydroquinoline
- Packaging
- 100mg
- Price
- $103
- Updated
- 2021/12/16
2-chloro-5,6,7,8-tetrahydroquinoline Chemical Properties,Usage,Production
Synthesis
54802-19-6
21172-88-3
The general procedure for the synthesis of 2-chloro-5,6,7,8-tetrahydroquinoline from 5,6,7,8-tetrahydro-2-quinolinone is as follows: 1. 20 g (0.134 mol) of 5,6,7,8-tetrahydro-2-quinolinone was added to a 250 mL two-necked flask with 28.8 mL (0.38 mol) of phosphorus trichloride (molar ratio 1:2.3) under dry conditions. 2. The reaction was rapidly stirred and heated to 135 °C and kept at reflux for 16 hours. 3. Upon completion of the reaction, the reaction mixture was cooled to 60-80 °C and then slowly poured under vigorous stirring into a 0.1% (W/V) sodium hydroxide solution pre-cooled to 0-5 °C to adjust the pH to 8.5. 4. Extract twice with 250 mL of dichloromethane at 0 °C and combine the organic phases. 5. Concentrate the organic phase by rotary evaporation to obtain the crude product. 6. The crude product was subjected to reduced pressure distillation at a pressure of 12-15 mmHg and the fractions with boiling ranges of 135-137 °C were collected to afford 20.3 g of colorless to pale yellow 2-chloro-5,6,7,8-tetrahydroquinoline liquid in 90% yield.
References
[1] Patent: CN103992270, 2016, B. Location in patent: Paragraph 0030-0033
[2] Patent: WO2006/35967, 2006, A1. Location in patent: Page/Page column 86
2-chloro-5,6,7,8-tetrahydroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
2-chloro-5,6,7,8-tetrahydroquinoline Suppliers
- Tel
- 792-3901125 13222993784
- Fax
- 0512-62575043
- sales@unite-pharm.com
- Country
- China
- ProdList
- 311
- Advantage
- 56
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 965
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 15021845385
- 765325601@qq.com
- Country
- China
- ProdList
- 3609
- Advantage
- 58
- Tel
- +1-858-6993322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
- Country
- United States
- ProdList
- 21193
- Advantage
- 58
- Tel
- +86 028-84641798 15982321820
- abby@arkpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- +8619521488211
- Fax
- +86 15821988213
- info@longyupharma.com
- Country
- China
- ProdList
- 2541
- Advantage
- 58
View Lastest Price from 2-chloro-5,6,7,8-tetrahydroquinoline manufacturers
- Product
- 2-chloro-5,6,7,8-tetrahydroquinoline 21172-88-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-07-12