2-chloro-5,6,7,8-tetrahydroquinoline

Product Name: 2-chloro-5,6,7,8-tetrahydroquinoline
CAS No.: 21172-88-3
Chemical Name: 2-chloro-5,6,7,8-tetrahydroquinoline
Synonyms: 2-chloro-5,6,7,8-tetrahydroquinoline;Quinoline, 2-chloro-5,6,7,8-tetrahydro-
CBNumber: CB31557823
Molecular Formula: C9H10ClN
Formula Weight: 167.64
MOL File: 21172-88-3.mol

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2-chloro-5,6,7,8-tetrahydroquinoline Property

Melting point:: 93-95 °C
Boiling point:: 260℃
Density: 1.185
Flash point:: 136℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.46±0.20(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C9H10ClN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h5-6H,1-4H2
InChIKey: ZUXMRCHYHAWERW-UHFFFAOYSA-N
SMILES: N1C2=C(CCCC2)C=CC=1Cl

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C433328
Product name: 2-Chloro-5,6,7,8-tetrahydroquinoline
Packaging: 20mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141269
Product name: 2-Chloro-5,6,7,8-tetrahydroquinoline
Packaging: 25mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141269
Product name: 2-Chloro-5,6,7,8-tetrahydroquinoline
Packaging: 50mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: Z4404
Product name: 2-Chloro-5,6,7,8-tetrahydroquinoline
Packaging: 100mg
Price: $103
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141269
Product name: 2-Chloro-5,6,7,8-tetrahydroquinoline
Packaging: 100mg
Price: $150
Updated: 2021/12/16

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2-chloro-5,6,7,8-tetrahydroquinoline Chemical Properties,Usage,Production

Synthesis

54802-19-6

21172-88-3

The general procedure for the synthesis of 2-chloro-5,6,7,8-tetrahydroquinoline from 5,6,7,8-tetrahydro-2-quinolinone is as follows: 1. 20 g (0.134 mol) of 5,6,7,8-tetrahydro-2-quinolinone was added to a 250 mL two-necked flask with 28.8 mL (0.38 mol) of phosphorus trichloride (molar ratio 1:2.3) under dry conditions. 2. The reaction was rapidly stirred and heated to 135 °C and kept at reflux for 16 hours. 3. Upon completion of the reaction, the reaction mixture was cooled to 60-80 °C and then slowly poured under vigorous stirring into a 0.1% (W/V) sodium hydroxide solution pre-cooled to 0-5 °C to adjust the pH to 8.5. 4. Extract twice with 250 mL of dichloromethane at 0 °C and combine the organic phases. 5. Concentrate the organic phase by rotary evaporation to obtain the crude product. 6. The crude product was subjected to reduced pressure distillation at a pressure of 12-15 mmHg and the fractions with boiling ranges of 135-137 °C were collected to afford 20.3 g of colorless to pale yellow 2-chloro-5,6,7,8-tetrahydroquinoline liquid in 90% yield.

References

[1] Patent: CN103992270, 2016, B. Location in patent: Paragraph 0030-0033
[2] Patent: WO2006/35967, 2006, A1. Location in patent: Page/Page column 86

2-chloro-5,6,7,8-tetrahydroquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-chloro-5,6,7,8-tetrahydroquinoline manufacturers

Career Henan Chemical Co

Product: 2-chloro-5,6,7,8-tetrahydroquinoline 21172-88-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-12

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2-chloro-5,6,7,8-tetrahydroquinoline

Quinoline, 2-chloro-5,6,7,8-tetrahydro-

21172-88-3