3-bromo-5-chloro-2-iodopyridine
- Product Name
- 3-bromo-5-chloro-2-iodopyridine
- CAS No.
- 823221-97-2
- Chemical Name
- 3-bromo-5-chloro-2-iodopyridine
- Synonyms
- 113612;3-bromo-5-chloro-2-iodopyridine;Pyridine, 3-bromo-5-chloro-2-iodo-
- CBNumber
- CB31558774
- Molecular Formula
- C5H2BrClIN
- Formula Weight
- 318.34
- MOL File
- 823221-97-2.mol
3-bromo-5-chloro-2-iodopyridine Property
- Melting point:
- 58-60 °C(Solv: methanol (67-56-1))
- Boiling point:
- 280.0±35.0 °C(Predicted)
- Density
- 2.395±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -2.80±0.20(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C5H2BrClIN/c6-4-1-3(7)2-9-5(4)8/h1-2H
- InChIKey
- INARBABVYJQJDC-UHFFFAOYSA-N
- SMILES
- C1(I)=NC=C(Cl)C=C1Br
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 3H32-W-00
- Product name
- 3-Bromo-5-chloro-2-iodopyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- 1376DL
- Product name
- 3-Bromo-5-chloro-2-iodopyridine
- Packaging
- 100mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- HCH0044617
- Product name
- 3-BROMO-5-CHLORO-2-IODOPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.17
- Updated
- 2021/12/16
- Product number
- 120794
- Product name
- 3-Bromo-5-chloro-2-iodopyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $1188
- Updated
- 2021/12/16
- Product number
- 1376DL
- Product name
- 3-Bromo-5-chloro-2-iodopyridine
- Packaging
- 10g
- Price
- $1370
- Updated
- 2021/12/16
3-bromo-5-chloro-2-iodopyridine Chemical Properties,Usage,Production
Synthesis
26163-03-1
823221-97-2
Acetonitrile (100 mL), elemental iodine (48.9 g, 192.8 mmol), cuprous iodide (23.9 g, 125.3 mmol), and tert-butyl nitrite (14.9 g, 144.6 mmol) were sequentially added to a 500 mL three-necked flask under nitrogen protection. Under cooling in an ice bath, 2-amino-3-bromo-5-chloropyridine (20.0 g, 96.4 mmol) was slowly added, followed by heating the reaction mixture to 60 °C and stirring the reaction for 2 hours. After completion of the reaction, water (45 mL) was added to the reaction mixture and the solid was collected by filtration. The filter cake was washed with ethyl acetate (45 mL x 1) and after combining the filtrates, the aqueous phase was further extracted with ethyl acetate (200 mL x 2). The organic phases were combined, washed with saturated aqueous sodium thiosulfate (110 mL × 2) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure, and the residue was pulped with a small amount of methanol, filtered, and dried to give 21.9 g of 3-bromo-5-chloro-2-iodopyridine white solid in 71.2% yield.
References
[1] Patent: CN106467488, 2017, A. Location in patent: Paragraph 0011; 0012; 0013; 0014; 0015; 0016-0037
[2] Tetrahedron, 2004, vol. 60, # 51, p. 11869 - 11874
3-bromo-5-chloro-2-iodopyridine Preparation Products And Raw materials
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