5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE
- Product Name
- 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE
- CAS No.
- 552330-86-6
- Chemical Name
- 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE
- Synonyms
- 5-Bromo-1-isoindolinone;3-DIHYDRO-ISOINDOL-1-ONE;5-bromo isoinoline-1-one;5-BroMo-1-oxo-isoindoline;5-Bromo-1-Isoindolinone,96%;5-BroMo-1-isoindolinone, 96%;5-Bromoisoindolin-1-one≥ 98%(GC);4-BroMo-2,3-dihydroisoindol-1-one;5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE;5-bromo-2,3-dihydroisoindole-1-one
- CBNumber
- CB31559892
- Molecular Formula
- C8H6BrNO
- Formula Weight
- 212.04
- MOL File
- 552330-86-6.mol
5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE Property
- Melting point:
- 267 °C
- Boiling point:
- 448.4±45.0 °C(Predicted)
- Density
- 1.666±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 13.75±0.20(Predicted)
- color
- White to Light yellow to Light red
- InChI
- InChI=1S/C8H6BrNO/c9-6-1-2-7-5(3-6)4-10-8(7)11/h1-3H,4H2,(H,10,11)
- InChIKey
- WJNKJYJCWXMBNV-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(Br)C=C2)CN1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B5328
- Product name
- 5-Bromoisoindolin-1-one
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- B695420
- Product name
- 5-Bromoisoindolin-1-one
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 073506
- Product name
- 5-Bromo-2,3-dihydroisoindol-1-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- FB63118
- Product name
- 5-Bromo-2,3-dihydroisoindol-1-one
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- FB63118
- Product name
- 5-Bromo-2,3-dihydroisoindol-1-one
- Packaging
- 2g
- Price
- $122
- Updated
- 2021/12/16
5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE Chemical Properties,Usage,Production
Chemical Properties
Pink Solid
Uses
5-Bromoisoindolin-1-one was one of the reagents in discovering a new, selective 3-aminopyrazole based MK2-inhibitors.
Synthesis
78471-43-9
552330-86-6
The general procedure for the synthesis of 5-bromo-2,3-dihydroisoindol-1-one from 4-bromo-2-bromomethylbenzoic acid methyl ester was as follows: 4-bromo-2-bromomethylbenzoic acid methyl ester (3.70 g) was suspended in a methanol solution of 2 M ammonia (36 mL) and concentrated ammonium hydroxide (12 mL) and the reaction was carried out for 18 hours. After completion of the reaction, the solid product was collected by filtration to afford 5-bromo-2,3-dihydroisoindol-1-one as a colorless solid (2.3 g, 90% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.68 (m, 3H), 4.44 (s, 2H).
References
[1] Patent: WO2006/20879, 2006, A1. Location in patent: Page/Page column 66-67
[2] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0637; 0638
[3] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 121
[4] Patent: WO2005/73205, 2005, A1. Location in patent: Page/Page column 25
[5] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 91-92
5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE Suppliers
- Tel
- +1-2266000236
- sales@rdscientific.com
- Country
- Canada
- ProdList
- 1902
- Advantage
- 58
View Lastest Price from 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE manufacturers
- Product
- 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE 552330-86-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19
- Product
- 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE 552330-86-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19