ChemicalBook > CAS DataBase List > 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE

5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE

Product Name
5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE
CAS No.
552330-86-6
Chemical Name
5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE
Synonyms
5-Bromo-1-isoindolinone;3-DIHYDRO-ISOINDOL-1-ONE;5-bromo isoinoline-1-one;5-BroMo-1-oxo-isoindoline;5-Bromo-1-Isoindolinone,96%;5-BroMo-1-isoindolinone, 96%;5-Bromoisoindolin-1-one≥ 98%(GC);4-BroMo-2,3-dihydroisoindol-1-one;5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE;5-bromo-2,3-dihydroisoindole-1-one
CBNumber
CB31559892
Molecular Formula
C8H6BrNO
Formula Weight
212.04
MOL File
552330-86-6.mol
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5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE Property

Melting point:
267 °C
Boiling point:
448.4±45.0 °C(Predicted)
Density 
1.666±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
13.75±0.20(Predicted)
color 
White to Light yellow to Light red
InChI
InChI=1S/C8H6BrNO/c9-6-1-2-7-5(3-6)4-10-8(7)11/h1-3H,4H2,(H,10,11)
InChIKey
WJNKJYJCWXMBNV-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=C(Br)C=C2)CN1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5328
Product name
5-Bromoisoindolin-1-one
Purity
>98.0%(GC)
Packaging
1g
Price
$84
Updated
2025/07/31
TRC
Product number
B695420
Product name
5-Bromoisoindolin-1-one
Packaging
1g
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
073506
Product name
5-Bromo-2,3-dihydroisoindol-1-one
Purity
95+%
Packaging
1g
Price
$49
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB63118
Product name
5-Bromo-2,3-dihydroisoindol-1-one
Packaging
1g
Price
$76
Updated
2021/12/16
Matrix Scientific
Product number
073506
Product name
5-Bromo-2,3-dihydroisoindol-1-one
Purity
95+%
Packaging
5g
Price
$145
Updated
2021/12/16
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5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE Chemical Properties,Usage,Production

Chemical Properties

Pink Solid

Uses

5-Bromoisoindolin-1-one was one of the reagents in discovering a new, selective 3-aminopyrazole based MK2-inhibitors.

Synthesis

78471-43-9

552330-86-6

The general procedure for the synthesis of 5-bromo-2,3-dihydroisoindol-1-one from 4-bromo-2-bromomethylbenzoic acid methyl ester was as follows: 4-bromo-2-bromomethylbenzoic acid methyl ester (3.70 g) was suspended in a methanol solution of 2 M ammonia (36 mL) and concentrated ammonium hydroxide (12 mL) and the reaction was carried out for 18 hours. After completion of the reaction, the solid product was collected by filtration to afford 5-bromo-2,3-dihydroisoindol-1-one as a colorless solid (2.3 g, 90% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.68 (m, 3H), 4.44 (s, 2H).

References

[1] Patent: WO2006/20879, 2006, A1. Location in patent: Page/Page column 66-67
[2] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0637; 0638
[3] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 121
[4] Patent: WO2005/73205, 2005, A1. Location in patent: Page/Page column 25
[5] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 91-92

5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE Suppliers

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View Lastest Price from 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE manufacturers

Career Henan Chemical Co
Product
5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE 552330-86-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19
Career Henan Chemical Co
Product
5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE 552330-86-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

552330-86-6, 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONERelated Search:

1,2-Bis(tetrabromophthalimido) ethane 3,4,5,6-TETRABROMOPHTHALIMIDE 4-Bromophthalimide 4-(5-BROMO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID 3-(5-BROMO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID 2-BENZYL-5-BROMOISOINDOLINE-1,3-DIONE (5-BROMO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID AURORA 17308 (6-BROMO-3-OXO-2,3-DIHYDRO-1 H-ISOINDOL-1-YL)-ACETIC ACID AURORA 17476 N,N'-(methylenedi-p-phenylene)bis[3,4,5,6,-tetrabromophthalimide] AURORA 17477 AURORA 17474 2-(5-BROMO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-3-METHYL-BUTYRIC ACID AURORA 22131 4,5,6,7-TETRABROMO-2-(OXIRAN-2-YLMETHYL)ISOINDOLINE-1,3-DIONE AURORA 17475 AURORA 9580

  • 5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE
  • 5-BroMo-1-isoindolinone, 96%
  • 4-BroMo-2,3-dihydroisoindol-1-one
  • 5-BroMo-1-oxo-isoindoline
  • 1H-Isoindol-1-one, 5-broMo-2,3-dihydro-
  • 5-BroMo-2,3-dihydro-1H-isoindol-1-one
  • 5-Bromo-2,3-dihydro-1-oxo-1H-isoindole
  • 5-Bromo-1-Isoindolinone,96%
  • 5-Bromoisoindolin-1-one≥ 98%(GC)
  • 5-Bromo-2,3-dihydro-1H-isoindol-1-one 98%
  • 3-DIHYDRO-ISOINDOL-1-ONE
  • 5-bromo-2,3-dihydroisoindole-1-one
  • 6(5H)-Phenanthridinone,3,11-dibromo-
  • 5-bromo isoinoline-1-one
  • 5-Bromo-2,3-dihydroisoindol-1-one, 98%min
  • 5-Bromo-1-isoindolinone
  • 552330-86-6