6-chloro-2-methoxynicotinaldehyde

Description

Product Name: 6-chloro-2-methoxynicotinaldehyde
CAS No.: 95652-81-6
Chemical Name: 6-chloro-2-methoxynicotinaldehyde
Synonyms: 6-chloro-2-methoxynicotinaldehyde;6-Chloro-2-methoxynicotinaldehyde 98%;6-Chloro-2-methoxy-3-pyridinecarbaldehyde;6-CHLORO-2-METHOXY-PYRIDINE-3-CARBALDEHYDE;6-Chloro-2-methoxypyridine-3-carboxaldehyde;6-Chloro-2-methoxy-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 6-chloro-2-methoxy-
CBNumber: CB31560175
Molecular Formula: C7H6ClNO2
Formula Weight: 171.58
MOL File: 95652-81-6.mol

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6-chloro-2-methoxynicotinaldehyde Property

Melting point:: 78-81°C
Boiling point:: 90 °C(Press: 3 Torr)
Density: 1.317±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: -1.59±0.10(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C7H6ClNO2/c1-11-7-5(4-10)2-3-6(8)9-7/h2-4H,1H3
InChIKey: AVBARORPQMEWPR-UHFFFAOYSA-N
SMILES: C1(OC)=NC(Cl)=CC=C1C=O

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 772747
Product name: 6-Chloro-2-methoxypyridine-3-carboxaldehyde
Purity: 97%
Packaging: 500mg
Price: $172
Updated: 2023/06/20

TRC

Product number: C597905
Product name: 6-Chloro-2-methoxynicotinaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR52468
Product name: 6-Chloro-2-methoxynicotinaldehyde
Purity: 98%
Packaging: 250mg
Price: $101
Updated: 2021/12/16

Apolloscientific

Product number: OR52468
Product name: 6-Chloro-2-methoxynicotinaldehyde
Purity: 98%
Packaging: 1g
Price: $267
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044896
Product name: 6-CHLORO-2-METHOXYNICOTINALDEHYDE
Purity: 95.00%
Packaging: 1G
Price: $994.46
Updated: 2021/12/16

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6-chloro-2-methoxynicotinaldehyde Chemical Properties,Usage,Production

Description

6-Chloro-2-methoxynicotinaldehyde is a useful research chemical.

Uses

6-chloro-2-methoxynicotinaldehyde is a heterocyclic derivative and can be used as a pharmaceutical intermediate.

Synthesis

17228-64-7

68-12-2

95652-81-6

GENERAL STEPS: 2-Chloro-6-methoxypyridine (5 g, 34.82 mmol) was dissolved in tetrahydrofuran (THF, 100 mL) under dry argon atmosphere and cooled to -78 °C. Tert-butyl lithium (tBuLi, 1.7 M, 18.5 mL, 31.34 mmol) was slowly added dropwise, keeping the temperature at -78 °C, and the reaction was stirred for 1 hour. Subsequently, N,N-dimethylformamide (DMF, 92.2 g, 31.34 mmol) was slowly added at the same temperature and stirring was continued for 2 hours. After completion of the reaction, the reaction was quenched with acetic acid and the mixture was poured into ice-cold water. The aqueous phase was alkalized with saturated sodium bicarbonate (NaHCO3) solution and subsequently extracted with ethyl acetate (EtOAc, 2 x 500 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent being a mixed solvent of petroleum ether and ethyl acetate (10:1, v/v) to afford 6-chloro-2-methoxypyridine-3-carboxaldehyde as a white solid (3.8 g, 65% yield). The mass spectrum (ES+) showed m/z 172 [M+H]+; elemental analysis (C7H6ClNO2) was consistent with the theoretical value; 1H NMR (300 MHz, CDCl3) δ 10.17 (s, 1H), 8.07 (d, J=8.04Hz, 1H), 7.03 (d, J=8.04Hz, 1H), 3.79 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5857 - 5867
[2] Patent: US2018/65917, 2018, A1. Location in patent: Paragraph 0209
[3] Patent: EP1405859, 2004, A1. Location in patent: Page 23
[4] Organic Letters, 2014, vol. 16, # 7, p. 1980 - 1983
[5] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 7, p. 723 - 732

6-chloro-2-methoxynicotinaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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6-chloro-2-methoxynicotinaldehyde Suppliers

China 97 India 1 United Kingdom 1 United States 6 Global 105

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Sigma-Aldrich

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View Lastest Price from 6-chloro-2-methoxynicotinaldehyde manufacturers

Shanghai Wish Pharma Co., Ltd

Product: 6-chloro-2-methoxynicotinaldehyde 95652-81-6
Price: US $0.00-0.00/kg
Min. Order: 0.5kg
Purity: Minimum 98%
Supply Ability: 100kg
Release date: 2025-11-06

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 6-Chloro-2-methoxynicotinaldehyde 95652-81-6
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: 6-chloro-2-methoxynicotinaldehyde 95652-81-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

95652-81-6, 6-chloro-2-methoxynicotinaldehydeRelated Search:

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95652-81-6