3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester
- Product Name
- 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester
- CAS No.
- 65515-32-4
- Chemical Name
- 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester
- Synonyms
- methyl 6-chloro-2-methoxynicotinate;2-chloro-6-methoxy-nicotinic acid methyl este;Methyl 6-chloro-2-methoxypyridine-3-carboxylate;3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester
- CBNumber
- CB72520833
- Molecular Formula
- C8H8ClNO3
- Formula Weight
- 201.61
- MOL File
- 65515-32-4.mol
3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester Property
- Boiling point:
- 262.0±35.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -1.81±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M340423
- Product name
- Methyl6-Chloro-2-methoxynicotinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M340423
- Product name
- Methyl6-Chloro-2-methoxynicotinate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H23-5-1N
- Product name
- Methyl 6-chloro-2-methoxynicotinate
- Packaging
- 500mg
- Price
- $298
- Updated
- 2021/12/16
- Product number
- 064090
- Product name
- Methyl 6-chloro-2-methoxypyridine-3-carboxylate
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $390
- Updated
- 2021/12/16
- Product number
- 4H23-5-1N
- Product name
- Methyl 6-chloro-2-methoxynicotinate
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester Chemical Properties,Usage,Production
Synthesis
124-41-4
65515-28-8
65515-32-4
Step 2: Synthesis of methyl 6-chloro-2-methoxynicotinate; Sodium methanol (34.25 g, 0.63 mol) was added one time to a solution of methyl 2,6-dichloronicotinate (105 g, 0.5 mol) in dichloromethane (523 mL) at -5 °C. The reaction mixture was slowly warmed to room temperature over 4 hours. Subsequently, additional sodium methanolate (5.48 g, 0.10 mol) was added and the mixture continued to be stirred for 12 hours. Upon completion of the reaction, the mixture was extracted by adding saturated aqueous sodium bicarbonate (300 mL), water (400 mL) and dichloromethane (300 mL) to the mixture. The organic and aqueous layers were separated and the aqueous layer was washed again with dichloromethane (200 mL). All organic layers were combined, washed with water (500 mL), dried with anhydrous magnesium sulfate, and filtered through diatomaceous earth. The filtrate was concentrated to give an oil, which was cooled and solidified to give the target product methyl 6-chloro-2-methoxynicotinate (95 g, 94% yield). The structure of the product was confirmed by 1H NMR (500 MHz, DMSO-d6): δ 3.81 (3H, s, OCH3), 3.93 (3H, s, COOCH3), 7.21 (1H, d, J = 7.8 Hz, Ar-H), 8.18 (1H, d, J = 7.8 Hz, Ar-H).
References
[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 53
[2] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7025 - 7029
[3] Patent: WO2006/112828, 2006, A1. Location in patent: Page/Page column 58
[4] Patent: US2005/119251, 2005, A1. Location in patent: Page/Page column 20; 22
[5] Patent: WO2006/14168, 2006, A1. Location in patent: Page/Page column 47
3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester manufacturers
- Product
- 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester 65515-32-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13