ChemicalBook > CAS DataBase List > 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester

3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester

Product Name: 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester
CAS No.: 65515-32-4
Chemical Name: 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester
Synonyms: methyl 6-chloro-2-methoxynicotinate;2-chloro-6-methoxy-nicotinic acid methyl este;Methyl 6-chloro-2-methoxypyridine-3-carboxylate;3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester
CBNumber: CB72520833
Molecular Formula: C8H8ClNO3
Formula Weight: 201.61
MOL File: 65515-32-4.mol

Less

3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester Property

Boiling point:: 262.0±35.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -1.81±0.10(Predicted)
Appearance: White to off-white Solid

Less

Safety

HazardClass: IRRITANT
HS Code: 2933399990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

TRC

Product number: M340423
Product name: Methyl6-Chloro-2-methoxynicotinate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M340423
Product name: Methyl6-Chloro-2-methoxynicotinate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-5-1N
Product name: Methyl 6-chloro-2-methoxynicotinate
Packaging: 500mg
Price: $298
Updated: 2021/12/16

Matrix Scientific

Product number: 064090
Product name: Methyl 6-chloro-2-methoxypyridine-3-carboxylate
Purity: 95+%
Packaging: 500mg
Price: $390
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-5-1N
Product name: Methyl 6-chloro-2-methoxynicotinate
Packaging: 1g
Price: $400
Updated: 2021/12/16

Less

3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester Chemical Properties,Usage,Production

Synthesis

124-41-4

65515-28-8

65515-32-4

Step 2: Synthesis of methyl 6-chloro-2-methoxynicotinate; Sodium methanol (34.25 g, 0.63 mol) was added one time to a solution of methyl 2,6-dichloronicotinate (105 g, 0.5 mol) in dichloromethane (523 mL) at -5 °C. The reaction mixture was slowly warmed to room temperature over 4 hours. Subsequently, additional sodium methanolate (5.48 g, 0.10 mol) was added and the mixture continued to be stirred for 12 hours. Upon completion of the reaction, the mixture was extracted by adding saturated aqueous sodium bicarbonate (300 mL), water (400 mL) and dichloromethane (300 mL) to the mixture. The organic and aqueous layers were separated and the aqueous layer was washed again with dichloromethane (200 mL). All organic layers were combined, washed with water (500 mL), dried with anhydrous magnesium sulfate, and filtered through diatomaceous earth. The filtrate was concentrated to give an oil, which was cooled and solidified to give the target product methyl 6-chloro-2-methoxynicotinate (95 g, 94% yield). The structure of the product was confirmed by 1H NMR (500 MHz, DMSO-d6): δ 3.81 (3H, s, OCH3), 3.93 (3H, s, COOCH3), 7.21 (1H, d, J = 7.8 Hz, Ar-H), 8.18 (1H, d, J = 7.8 Hz, Ar-H).

References

[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 53
[2] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7025 - 7029
[3] Patent: WO2006/112828, 2006, A1. Location in patent: Page/Page column 58
[4] Patent: US2005/119251, 2005, A1. Location in patent: Page/Page column 20; 22
[5] Patent: WO2006/14168, 2006, A1. Location in patent: Page/Page column 47

3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester Suppliers

China 87 India 1 United Kingdom 1 United States 7 Global 96

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai Hong-chuang Pharma Tech Co., Ltd.

Tel: 18151128828
Fax: -
Email: hc-sales@foxmail.com
Country: China
ProdList: 2647
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Nantong MYBio-pharm. Co., Ltd.

Tel: 0513-85921823 18662920231
Fax: 86-513-85012876
Email: sales@ntminyanmedical.com
Country: China
ProdList: 4113
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Nantong Bosu Pharmaceutical Technology Co., Ltd.

Tel: 0513-0513-51005092 13390947892
Fax: 0513-51005092
Email: tashiyxy@163.com
Country: China
ProdList: 838
Advantage: 58

ShangHai Yuchuan Pharmaceutical Technology Co., Ltd.

Tel: 02161555100
Fax: -
Country: China
ProdList: 820
Advantage: 58

Shanghai XR Chemical Technology Co., Ltd.

Tel: 021-31007982 18019432809
Fax: 021-31007982
Email: info@xrpharma.com
Country: China
ProdList: 676
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Shanghai GaoDao Pharmaceutical Co., Ltd.

Tel: 021-15001867143 15001867143
Fax: -
Email: 1095570358@qq.com
Country: China
ProdList: 907
Advantage: 55

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: 41513101@qq.com
Country: China
ProdList: 1785
Advantage: 55

Chongqing AoShe Biological Chemical Co., Ltd.

Tel: 023-63225655 13320248848
Fax: 023-63225655QQ2366581735
Email: 2366581735@qq.com
Country: China
ProdList: 511
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Suzhou Nuoouman Biological Technology Co., Ltd.

Tel: 15026866316
Email: 180642609@qq.com
Country: China
ProdList: 4967
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-63315541 13323832564
Fax: QQ:3001332135
Email: 3001332135@qq.com
Country: China
ProdList: 9972
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai Sealing Biotechnology Co. Ltd..

Tel: 15721176654
Email: 1815535157@qq.com
Country: China
ProdList: 881
Advantage: 58

Shanghai Moss Medicine Technology Co., Ltd.

Tel: +86-188369842 +86-15618151133
Fax: QQ188369842
Email: 188369842@qq.com
Country: China
ProdList: 1959
Advantage: 58

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 11811
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13966
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Nantong puyue biomedical Co., Ltd

Tel: 0513-0513-0513-89158300 18014392889
Fax: 0513-89158198
Email: sales@puyerbiopharma.com
Country: China
ProdList: 4956
Advantage: 58

Huzhou fuhe Rui biological medicine co., ltd

Tel: 13626726938
Country: China
ProdList: 791
Advantage: 58

Guangzhou Yuheng Pharmaceutical Technology Co., Ltd

Tel: +8613580539051
Email: joe@yuhengpharm.com
Country: CHINA
ProdList: 21142
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

Zhengzhou Alpha Chemical Co. LTD

Tel: 0371-0371-53732842 13383863444
Fax: QQ：3002612166
Email: 3002612166@qq.com
Country: China
ProdList: 9996
Advantage: 58

Shanghai Sunmonth Technology Co., LTD

Tel: 15216675652
Email: xuanyuelj@163.com
Country: China
ProdList: 2864
Advantage: 58

Shandong Territorial sea Biological Technology Co., LTD

Tel: 15092083467
Email: 18660263263@163.com
Country: China
ProdList: 2811
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Changzhou Xiya Biotechnology Co., Ltd.

Tel: 13775267187
Email: 391097727@qq.com
Country: China
ProdList: 996
Advantage: 58

Nanjing Yili Biotechnology Co., Ltd.

Tel: 15380789538
Email: 2885743537@qq.com
Country: China
ProdList: 8205
Advantage: 58

Beijing Stronger Science Co., Ltd.

Tel: 0531-88924771 15614660963
Email: elsa.hang@strongerscience.com
Country: China
ProdList: 10623
Advantage: 58

Less

View Lastest Price from 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester manufacturers

Career Henan Chemical Co

Product: 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester 65515-32-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-01-13

65515-32-4, 3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl esterRelated Search:

6-Chlorothiazolo[4,5-b]pyridine-2-thiol 6-Chloro-2-fluoro nicotinic acid 6-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID 6-chloro-2-methoxynicotinic acid 6-CHLORO-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 6-Chloro-2-fluoropyridine-3-boronic acid 6-chloro-2-methoxynicotinaldehyde 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-2-Methyl- 4,5-Pyrimidinediamine, 6-chloro-2-methyl- 2-Benzothiazolecarbonitrile,6-chloro-(8CI,9CI) 6-CHLORO-2-FLUORO-NICOTINIC ACID METHYL ESTER 6-chloro-2-methyl-4(1H)-quinazolinone 3-Pyridinol,6-chloro-2-methyl-(9CI) 6-Chloropyridine-2-carbaldehyde 6-Chloro-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 6-Chloro-2-(trifluoroMethyl)quinazolin-4(3H)-one 6-Chloro-2-fluoro-3-iodopyridine, 95% 6-CHLORO-3-METHOXY-2-METHYLPYRIDINE

3-Pyridinecarboxylic acid, 6-chloro-2-methoxy-, methyl ester

methyl 6-chloro-2-methoxynicotinate

Methyl 6-chloro-2-methoxypyridine-3-carboxylate

2-chloro-6-methoxy-nicotinic acid methyl este

65515-32-4