4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Product Name: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
CAS No.: 119018-29-0
Chemical Name: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
Synonyms: GLMN-C;Glimepiride imp B;Glemyurea impurity B;GLIMEPIRIDE EP IMP B;Glimepiride impurity2;GliMepiride IMpurity B;Glimepiride sulfonamide;Glimeperide sulfonamide;SulfonamideofGlimepiride;Glimepiride Sulphonamide
CBNumber: CB3156704
Molecular Formula: C16H21N3O4S
Formula Weight: 351.42
MOL File: 119018-29-0.mol

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4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Property

Melting point:: 177-179?C
Density: 1.304
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 10.16±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C16H21N3O4S/c1-3-14-11(2)10-19(15(14)20)16(21)18-9-8-12-4-6-13(7-5-12)24(17,22)23/h4-7H,3,8-10H2,1-2H3,(H,18,21)(H2,17,22,23)
InChIKey: AJEMFZRCUKJSES-UHFFFAOYSA-N
SMILES: N1(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)CC(C)=C(CC)C1=O
CAS DataBase Reference: 119018-29-0(CAS DataBase Reference)

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Safety

Risk Statements: 52/53
Safety Statements: 61
HS Code: 2935909550

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1726
Product name: Glimepiride Sulfonamide
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 40 mg
Price: $626.05
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1292325
Product name: Glimepiride Related Compound B
Packaging: 20mg
Price: $1200
Updated: 2025/07/31

AK Scientific

Product number: J10685
Product name: Glimepiride Related Compound B
Packaging: 100mg
Price: $247
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 10109
Product name: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
Packaging: 125mg
Price: $2120
Updated: 2021/12/16

BLDpharm

Product number: BD17708
Product name: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
Purity: 98%
Packaging: 1g
Price: $17
Updated: 2021/12/16

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4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide (Glimepiride EP Impurity B) is an intermediate for the preparation of Glimepiride.

Synthesis

119043-16-2

119018-29-0

38.0 kg of methanol and 5.1 kg of industrial ammonia were sequentially added to a 100 L reactor and stirring was initiated. The crude wet product of Intermediate 2 was added slowly at 20-30°C and the reaction was maintained for 2 hours. The progress of the reaction was monitored by HPLC and after the reaction was complete, filtration was carried out and the filter cake was washed with deionized water. The obtained crude wet product of white Intermediate 3 was directly transferred to a 200 L reactor. Subsequently, 110.0 kg of methanol was added, the reaction temperature was raised and stirring was continued for 4 hours. After completion of the reaction, the mixture was cooled to 20-25 °C, the product was separated by filtration and dried to obtain 8.47 kg of white solid Intermediate 3 refined product, with purity >99% and interstitial isomer impurity content of 0.2% by HPLC.

References

[1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855
[2] Patent: WO2006/103690, 2006, A1. Location in patent: Page/Page column 7,14-15
[3] Patent: CN108383768, 2018, A. Location in patent: Paragraph 0101; 0102

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Suppliers

Canada 2 China 207 Germany 1 India 29 United Kingdom 4 United States 13 Global 256

Cangzhou Senary Chemical Science-tech Co., Ltd.

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Beijing Isomersyn Technology CO;LTD

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Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
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View Lastest Price from 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide 119018-29-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000kgs
Release date: 2025-05-08

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide 119018-29-0
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500kg
Release date: 2021-09-16

Shaanxi Dideu New Materials Co. Ltd

Product: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide 119018-29-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-04-12

119018-29-0, 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamideRelated Search:

Formamide Formamide,Deionized Kresoxim-methyl METSULFURON METHYL Tribenuron methyl N-Ethylmethylamine PHENYL VALERATE Benzamide Chlorantraniliprole Methyl acetate N,N-Dimethylformamide Methyl salicylate Thiophanate-methyl Methyl [[4-[2-[[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)carbonyl]amino]ethyl]phenyl]sulfonyl]-carbamic acid ethyl ester Glimepiride Phenethyl isocyanate 3-Ethyl-2,5-Dihydro-4-Methyl-2-Oxo-N-(2-Phenylethyl)-1h-Pyrrole-1-Carboxamide

n-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-1h-pyrrole-1-carboxamide

N-[2-[4-(AMINOSULFONYL)PHENYL]ETHYL]-3-ETHYL-4-METHYL-2-OXO-1H-PYRROLE-1-CARBOXAMIDE

4-(2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamido)-Ethyl)-Benzenesulfonyl A

4-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamidoethyl]benzenesulfonamide

N-[4-2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamido)-Ethyl]Benzensulfonamide

4-[2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamide)Ethyl]Sulphonamide

Glimepiride Impurity 2(Glimepiride EP Impurity B)

Glimepiride sulfonamide

4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]benezenesulfonamide

SulfonamideofGlimepiride

4-[2-(3-ETHYL-4-METHYL-2-OXO-3-PYRROLINE-1-CARBOXAMINDO)ETHYL]BENZENESULFONAMIDE

3-Ethyl-2,5-dihydro-4-methyl-N-{2-[4-(aminosulfonyl)phenyl]ethyl}-2-oxo-1H-pyrrole--1-carboxamide

3-ETHYL-4-METHYL-2-OXO-N-(2-(P-AMINOSULFONYLPHENYL)ETHYL)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE

N-[2-[4-(AMINOSULFONYL)PHENYL]-3-ETHYL-2,5-DIHYDRO-4-METHYL-2-OXO]-1H-PYRROLE-1-CARBOXAMIDE

Des[(trans-4-methylcyclohexyl)amino]carbonyl Glimepiride

4-(2-((3-ethyl-4-methyl-2-oxo-pyrrolin-1-yl)carboxamido)ethyl)benzenesulfonamide)

Glimepiride Related Compound B (20 mg) (glimepiride sulfonamide)

4-[2-(3-ETHYL-4-METHYL-2-OXO-3-PYROLIDINE-1-CARBOXAMIDO) ETHYL]BENZENE SULPHONAMIDE

GliMepiride EP IMpurity B

4-[2-(3-ethyl-4-Methyl-2-oxo-pyrroline-1-carboxaMido)-ethyl] Benzene sulfonaMide

GliMepiride IMpurity B

1H-Pyrrole-1-carboxaMide,N-[2-[4-(aMinosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-Methyl-2-oxo-

Glimepiride Related Compound B (20 mg) (glimepiride sulfonamide, or 3-Ethyl-4-methyl-2-oxo-N-(4-sulfamoylphenethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide)

4-(2-(3-ETHYLMETHYL-2-CARBONYLPYRROLIDINYLAMINO)ETHYL)BENZENESULFONAMIDE

4-[2-(3-ethyl-4-methyl-2-oxy-3-pyrrolinyl-1-methylamide)benzene sulfonamide]

GliMepiride Related CoMpound B

Glimepiride impurity2

4-(2-(3-ethyl-4-methyl-2-oxo-pyrroline-1-carboxamido)-ethyl))

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

GLIMEPIRIDE SULPHONAMIDE (4-(2-(3-ETHYL- 4-METHYL-2-OXO-3-PYRROLINE-1-CARBOXAMIDE )ETHYL)BENZENESULPHONAMIDE (OTHER)

Glimepiride imp B

4-ethyl-3-methyl-5-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-pyrrole-1-carboxamide

GLIMEPIRIDE SULPHONAMIDE (4-(2-(3-ETHYL- 4-METHYL-2-OXO-3-PYRROLINE-1-CARBOXAMIDE )ETHYL)BENZENESULPHONAMIDE

3-ETHYL-4-METHYL-2-OXO-N-(2-(P-AMINOSULFONYLPHENYL)ETHYL)-2,5-DIHYDRO-1H-PYRROLE-1-

Glimepiride impurityⅢ{4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl] Benzene sulfonamide}

3-Ethyl-4-methyl-2-oxo-N-[2-(4-sulp

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide/Glimepiride Impurity B

4-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-2-carboxamide)ethyl)Benzene sulfonamide

GLMN-C

Glimepiride EP Impurity B/ Glimepiride Related Compound B (Glimepiride Sulfonamide)

4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrrolin-1)carboxamido]ethyl]benzene sulfonamide

Glimepiride Sulphonamide

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrroline)carboxamido]ethyl]...

Glimepiride Related Compound B (1292325)

Glimepiride Related Compound B (glimepiride sulfonamide, or 3-Ethyl-4-methyl-2-oxo-N-(4-sulfamoylph (1292325)

Glimepiride impurityⅢ {4-[2-(3-ethyl-4-methyl-2-oxo- 3-pyrroline-1-carboxamido)-eth yl] Benzene sulfonamide}

Glimepiride USP Related Compound B

3-ethyl-4-methyl-2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2,3-dihydro-1H-pyrrole-1-carboxamide

Glemyurea impurity B

EP IMPURITY-B/GLIMEPIRIDE SULFOMIDE

4- [2- (3-ethyl-4-methyl-2-oxo-3-pyrroline-1-formamido) ethyl] - benzenesulfonamide

Glimeperide sulfonamide

N -{2-[4-(aminosulfonyl) phenyl] ethyl}- 3-ethyl-4methyl-2-oxo-2,5- dihydro-1H-pyrrole-1- carboxamide

3-ethyl-4-methyl-2-oxo-N-[2-(3-sulfamoylphenyl) ethyl]-2,5-dihydro-1H-pyrrole-1-carboxamide

N-{4-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline)-1-carboxamido]ethyl} phenyl sulfonamide

Glimipiride imp B / Glimepiride Related Compound B

Sulphonamide of Glimipride

GLIMEPIRIDE EP IMP B