ChemicalBook > CAS DataBase List > 2-Chloro-6-aminopyrazine

2-Chloro-6-aminopyrazine

Product Name
2-Chloro-6-aminopyrazine
CAS No.
33332-28-4
Chemical Name
2-Chloro-6-aminopyrazine
Synonyms
TIMTEC-BB SBB005488;6-chlorpyrazin-2-amin;6-CHLOROPYRAZIN-2-AMINE;6-Chloro-2-pyrazinaMine;6-Chloro-2-aMinopyrazine;6-AMino-2-chloropyrazine;2-chloro-6-aminopyrazine;2-AMINO-6-CHLOROPYRAZINE;6-Chloro-2-pyrazinylaMine;6-CHLOROPYRAZIN-2-YLAMINE
CBNumber
CB3160912
Molecular Formula
C4H4ClN3
Formula Weight
129.55
MOL File
33332-28-4.mol
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2-Chloro-6-aminopyrazine Property

Melting point:
150-152°C
Boiling point:
282.8±35.0 °C(Predicted)
Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Soluble in dimethyl sulfoxide and methanol.
form 
Solid
pka
0.89±0.10(Predicted)
color 
Purple
InChI
InChI=1S/C4H4ClN3/c5-3-1-7-2-4(6)8-3/h1-2H,(H2,6,8)
InChIKey
JTPXVCKCLBROOJ-UHFFFAOYSA-N
SMILES
C1(N)=NC(Cl)=CN=C1
LogP
0.950
CAS DataBase Reference
33332-28-4(CAS DataBase Reference)
EPA Substance Registry System
2-Amino-6-chloropyrazine (33332-28-4)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-22
Safety Statements 
26-36/37/39-60-37
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2145
Product name
2-Amino-6-chloropyrazine
Purity
>98.0%(GC)
Packaging
1g
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
A2145
Product name
2-Amino-6-chloropyrazine
Purity
>98.0%(GC)
Packaging
5g
Price
$111
Updated
2025/07/31
TRC
Product number
C380350
Product name
6-Chloro-2-pyrazinamine
Packaging
50g
Price
$195
Updated
2021/12/16
TRC
Product number
C380350
Product name
6-Chloro-2-pyrazinamine
Packaging
100g
Price
$445
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0018396
Product name
2-AMINO-6-CHLOROPYRAZINE
Purity
95.00%
Packaging
1G
Price
$721.57
Updated
2021/12/16
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2-Chloro-6-aminopyrazine Chemical Properties,Usage,Production

Chemical Properties

2-Chloro-6-aminopyrazine is Purple Solid

Uses

2-Chloro-6-aminopyrazine is a disubstituted pyrazine used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.

Uses

2-Amino-6-chloropyrazine is used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.

Synthesis

4774-14-5

33332-28-4

General procedure for the synthesis of 2-amino-6-chloropyrazine from 2,6-dichloropyrazine: 2,6-dichloropyrazine (10.0 g, 67.1 mmol) and ammonia (100 mL) were sequentially added to a hydrothermal reactor and reacted at 100 °C for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was collected by filtration. The filter cake was pulped with hexane (16 mL) to give a final white solid of 8.2 g of 2-amino-6-chloropyrazine in 95.0% yield.

References

[1] Patent: CN107857737, 2018, A. Location in patent: Paragraph 0011-0013; 0021-0023; 0030-0032; 0040-0042; 0049
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 24, p. 8328 - 8342
[3] Patent: WO2013/68755, 2013, A1. Location in patent: Page/Page column 67, 68
[4] Patent: WO2017/5786, 2017, A1. Location in patent: Page/Page column 23; 24
[5] Tetrahedron, 1984, vol. 40, # 24, p. 5081 - 5088

2-Chloro-6-aminopyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-6-aminopyrazine Suppliers

Americas 1 Canada 2 China 273 Europe 1 Germany 5 India 7 Japan 3 Ukraine 1 United Kingdom 15 United States 41 USA 1 Global 350
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View Lastest Price from 2-Chloro-6-aminopyrazine manufacturers

R&D Scientific Inc.
Product
2-Amino-6-chloropyrazine 33332-28-4
Price
US $650.00/Kg
Min. Order
1Kg
Purity
98
Supply Ability
500 Kg
Release date
2024-03-27
Hebei Zhanyao Biotechnology Co. Ltd
Product
2-Chloro-6-aminopyrazine Basic information 33332-28-4
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-13
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-6-aminopyrazine 33332-28-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%+
Supply Ability
800 tons
Release date
2020-04-28

33332-28-4, 2-Chloro-6-aminopyrazineRelated Search:

Sulfachoropyrazine sodium Pyrazinamide Hydrochlorothiazide Glipizide Aminopyrazine N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO 2-Amino-5-chloropyrazine 2-Chloro-6-(1H-imidazol-1-yl)pyrazine MK 212 HYDROCHLORIDE 6'-CHLORO-2,3,5,6-TETRAHYDRO-[1,2']BIPYRAZINYL-4-CARBOXYLIC ACID TERT-BUTYL ESTER 6-Chloro-N-cyclohexylpyrazin-2-amine (6-chloropyrazin-2-yl)cyclopropylamine Difluorochloromethane 6-Chloro-N-(3-methoxypropyl)pyrazin-2-amine METHYL 3-AMINO-5,6-DICHLORO-2-PYRAZINECARBOXYLATE 2-Chloro-6-(1H-pyrazol-1-yl)pyrazine 95% 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride (6-chloropyrazin-2-yl)pentylamine

  • 2-AMINO-6-CHLOROPYRAZINE
  • 6-CHLOROPYRAZIN-2-YLAMINE
  • 6-CHLOROPYRAZIN-2-AMINE
  • 2-chloro-6-aminopyrazine
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  • TIMTEC-BB SBB005488
  • 6-AMino-2-chloropyrazine
  • 6-Chloro-2-aMinopyrazine
  • 6-Chloro-2-pyrazinaMine
  • 6-Chloro-2-pyrazinylaMine
  • 2-AMino-6-chloropyrazine, 97+%
  • 2-PyrazinaMine, 6-chloro-
  • 2-Amino-6-chloropyrazine &gt
  • 6-chlorpyrazin-2-amin
  • 2-Chloro-6-aminopyrazine ISO 9001：2015 REACH
  • 2-Chloro-6-aminopyrazine Basic information
  • 33332-28-4
  • amine| alkyl chloride
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrazine
  • Pyrazines
  • Nitrogen cyclic compounds
  • Amines
  • blocks