2-Methyl-4H-3,1-benzoxazin-4-one

Product Name: 2-Methyl-4H-3,1-benzoxazin-4-one
CAS No.: 525-76-8
Chemical Name: 2-Methyl-4H-3,1-benzoxazin-4-one
Synonyms: NSC 10119;NSC 521353;ACETANTHRANIL;AURORA KA-3785;Acetylanthranyl;ACETYL ANTHRANIL;TIMTEC-BB SBB000135;2-METHYL-3,1-BENZOXAZA-4-ONE;2-methyl-3,1-benzoxazin-4-one;2-methyl-4h-1-benzoxazin-4-one
CBNumber: CB3163296
Molecular Formula: C9H7NO2
Formula Weight: 161.16
MOL File: 525-76-8.mol

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2-Methyl-4H-3,1-benzoxazin-4-one Property

Melting point:: 79-82 °C(lit.)
Boiling point:: 144-145 °C(Press: 12 Torr)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.84±0.20(Predicted)
InChI: InChI=1S/C9H7NO2/c1-6-10-8-5-3-2-4-7(8)9(11)12-6/h2-5H,1H3
InChIKey: WMQSKECCMQRJRX-UHFFFAOYSA-N
SMILES: N1C2=CC=CC=C2C(=O)OC=1C
EPA Substance Registry System: 4H-3,1-Benzoxazin-4-one, 2-methyl- (525-76-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 457752
Product name: 2-Methyl-4H-3,1-benzoxazin-4-one
Purity: 98%
Packaging: 10g
Price: $62.9
Updated: 2024/03/01

AK Scientific

Product number: J55474
Product name: 2-Methyl-4H-benzo[d][1,3]oxazin-4-one
Packaging: 5g
Price: $70
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021356
Product name: 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE
Purity: 95.00%
Packaging: 0.5G
Price: $682
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021356
Product name: 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE
Purity: 95.00%
Packaging: 1G
Price: $750.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021356
Product name: 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE
Purity: 95.00%
Packaging: 5G
Price: $1328.25
Updated: 2021/12/16

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2-Methyl-4H-3,1-benzoxazin-4-one Chemical Properties,Usage,Production

Uses

2-Methyl-4H-3,1-benzoxazin-4-one is a synthetic antimicrobial agent. It belongs to the quinazolinone class of drugs. It has been shown to be effective against Staphylococcus aureus and other bacteria. Quinazolinones are potent inhibitors of bacterial growth and have been used successfully in the treatment of tuberculosis and other infectious diseases. 2-Methyl-4H-3,1-benzoxazin-4-one has also been shown to inhibit the growth of some Gram-negative bacteria, such as Salmonella typhi and Escherichia coli.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038

Synthesis

In 250 mL of RBF took (0.01 mole or 1.37 gm) anthranilic acid (2-amino benzoic acid) to that added 15 mL of acetic anhydride (excess) with porcelain chips. Reflux the solution at 35-40 ℃ for 50-55 min on heating mantle. TLC was done using EA: n-hexane (1:1) solvent system. Then removed the excess solvent (acetic anhydride) at low pressure using rotatory evaporator, To the remaining solid, added petroleum ether (40-60) to extract the 2-methyl-4H-3,1-benzoxazin-4-one. Repeated petroleum ether step to extract the entire product. After drying of petroleum-ether, the crystals of 2-methyl-4H-3, 1-benzoxazin-4-one was obtained and then it was recrystallized with ethanol8. M.P 80-82℃, Yield 79 %.

2-Methyl-4H-3,1-benzoxazin-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-4H-3,1-benzoxazin-4-one Suppliers

Austria 1 China 97 Germany 1 India 6 Switzerland 1 United Kingdom 4 United States 16 Global 126

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View Lastest Price from 2-Methyl-4H-3,1-benzoxazin-4-one manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Methyl-4H-3,1-benzoxazin-4-one 525-76-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1000Tons
Release date: 2024-07-05

Henan Fengda Chemical Co., Ltd

Product: 2-Methyl-4H-3,1-benzoxazin-4-one 525-76-8
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

Marvel pharm limited

Product: 2-methyl-3,1-benzoxazin-4-one 525-76-8
Price: US $0.00-0.00/kg
Min. Order: 100kg
Purity: 98%
Supply Ability: 10tons
Release date: 2023-12-19

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