4-FLUOROPHENYLMAGNESIUM BROMIDE Property

Melting point:

5 °C

Boiling point:

66°C

Density 

1.043 g/mL at 25 °C

Flash point:

−40 °F

storage temp. 

Flammables + water-Freezer (-20°C)e area

form 

Solution

color 

Clear yellow to red-brown

Water Solubility 

It reacts violently with water.

Sensitive 

Air & Moisture Sensitive

BRN 

636802

InChIKey

QYBFFRXNNFXREA-UHFFFAOYSA-M

CAS DataBase Reference

352-13-6

EPA Substance Registry System

Magnesium, bromo(4-fluorophenyl)- (352-13-6)

Safety

Hazard Codes 

F+,C,F

Risk Statements 

12-14-22-34-66-67-11-40-37-19

Safety Statements 

16-26-36/37/39-43-45-7/8-33-8-7

RIDADR 

UN 2924 3/PG 2

WGK Germany 

1

F 

10-21

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29319090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H371May cause damage to organs

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

4-FLUOROPHENYLMAGNESIUM BROMIDE Chemical Properties,Usage,Production

Chemical Properties

clear yellow to red-brown solution

Uses

4-Fluorophenylmagnesium bromide is used as a reagent for the introduction of the 4-Fluorophenyl group.

Uses

4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:

• Useful key intermediate in the synthesis of paroxetine.
• Arylsulfides via cross-coupling reaction with thiols.
• 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
• Grignard intermediate for preparing aprepitant.